DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1679 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1987 |
|
| 6 | 1684 |
|
| 7 | 1050 |
|
| 8 | 595 |
|
| 9 | 336 |
|
| 10 | 152 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 5215 |
|
5088 |
|
| 2 | 2306 |
|
694 |
|
| 3 | 347 |
|
||
| 4 | 85 |
|
||
| 5 | 19 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 5542 |
|
5793 |
|
| 2 | 748 |
|
781 |
|
| 3 | 262 |
|
206 |
|
| 4 | 85 |
|
44 |
|
| 5 | 9 |
|
15 |
|
| 6 | 2 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -7127.622508 |
|
| 2 | -7001.800313 |
|
| 3 | -1179.87195 |
|
| 4 | -939.576878 |
|
| 5 | -780.983485 |
|
| 6 | -780.570375 |
|
| 7 | -219.904457 |
|
| 8 | -182.965703 |
|
| 9 | -167.713738 |
|
| 10 | -167.472684 |
|
| 11 | -162.357288 |
|
| 12 | -144.354551 |
|
| 13 | -137.176319 |
|
| 14 | -135.087742 |
|
| 15 | -109.125858 |
|
| 16 | -103.413684 |
|
| 17 | -80.04596 |
|
| 18 | -53.631777 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -11732.680916 |
|
-10857.826761 |
|
| 2 | -9182.336875 |
|
-10147.137517 |
|
| 3 | -2125.802196 |
|
-2332.806231 |
|
| 4 | -731.427757 |
|
-814.759799 |
|
| 5 | -618.99558 |
|
-673.917651 |
|
| 6 | -618.99558 |
|
-379.127032 |
|
| 7 | -383.787215 |
|
-235.066081 |
|
| 8 | -252.883462 |
|
-182.979844 |
|
| 9 | -227.806936 |
|
-85.233962 |
|
| 10 | -177.97487 |
|
-69.944392 |
|
| 11 | -149.025928 |
|
-11.522315 |
|
| 12 | -144.076548 |
|
||
| 13 | -139.154672 |
|
||
| 14 | -125.324406 |
|
||
| 15 | -96.239549 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -10678.616472 |
|
-10334.312655 |
|
| 2 | -8708.481889 |
|
-8765.070349 |
|
| 3 | -2547.479848 |
|
-4275.035814 |
|
| 4 | -193.297643 |
|
-2374.473978 |
|
| 5 | -162.756952 |
|
-172.013198 |
|
| 6 | -152.748653 |
|
-86.335988 |
|
| 7 | -77.650283 |
|
-81.85229 |
|
| 8 | -62.847663 |
|
-46.394562 |
|
| 9 | -47.884574 |
|
-14.627634 |
|
| 10 | -21.689551 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 2.9e-215 |
|
| 3 | 9.2e-99 |
|
| 4 | 3.7e-71 |
|
| 5 | 2.3e-62 |
|
| 6 | 9.8e-31 |
|
| 7 | 6.6e-26 |
|
| 8 | 3.1e-09 |
|
| 9 | 5.2e-06 |
|
| 10 | 0.009 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 0.0 |
|
0.0 |
|
| 3 | 1.6e-96 |
|
1.6e-122 |
|
| 4 | 1.1e-75 |
|
1.1e-11 |
|
| 5 | 6.9e-60 |
|
190000.0 |
|
| 6 | 1.4e-36 |
|
640000.0 |
|
| 7 | 3.7e-32 |
|
640000.0 |
|
| 8 | 1.1e-28 |
|
1500000.0 |
|
| 9 | 2.8e-22 |
|
1500000.0 |
|
| 10 | 1.3e-14 |
|
2600000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 0.0 |
|
9.6e-197 |
|
| 3 | 4e-97 |
|
7.2e-97 |
|
| 4 | 2e-86 |
|
6.6e-35 |
|
| 5 | 2.4e-16 |
|
2.5e-14 |
|
| 6 | 1400.0 |
|
9100.0 |
|
| 7 | 5800.0 |
|
30000.0 |
|
| 8 | 29000.0 |
|
57000.0 |
|
| 9 | 150000.0 |
|
80000.0 |
|
| 10 | 350000.0 |
|
350000.0 |
|