DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1966 |
|
| 5 | 1298 |
|
| 6 | 668 |
|
| 7 | 385 |
|
| 8 | 53 |
|
| 9 | 33 |
|
| 10 | 33 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 9515 |
|
12516 |
|
| 2 | 4176 |
|
1363 |
|
| 3 | 342 |
|
1040 |
|
| 4 | 183 |
|
265 |
|
| 5 | 84 |
|
||
| 6 | 3 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 11278 |
|
12679 |
|
| 2 | 2701 |
|
1561 |
|
| 3 | 1137 |
|
894 |
|
| 4 | 363 |
|
||
| 5 | 134 |
|
||
| 6 | 15 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -33720.559701 |
|
| 2 | -9277.300908 |
|
| 3 | -5872.445319 |
|
| 4 | -5334.922393 |
|
| 5 | -5225.446339 |
|
| 6 | -4108.335381 |
|
| 7 | -4061.287522 |
|
| 8 | -2657.087975 |
|
| 9 | -2363.188823 |
|
| 10 | -2058.069198 |
|
| 11 | -1986.573666 |
|
| 12 | -1830.896312 |
|
| 13 | -1745.519658 |
|
| 14 | -1416.489977 |
|
| 15 | -1369.951255 |
|
| 16 | -930.889478 |
|
| 17 | -710.555677 |
|
| 18 | -667.334211 |
|
| 19 | -400.839907 |
|
| 20 | -331.330306 |
|
| 21 | -246.519785 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -13965.02972 |
|
-24727.287334 |
|
| 2 | -2462.917111 |
|
-4341.480543 |
|
| 3 | -1679.604559 |
|
-2929.310981 |
|
| 4 | -1274.639562 |
|
-2856.410281 |
|
| 5 | -619.232083 |
|
-959.237901 |
|
| 6 | -610.325465 |
|
-814.491085 |
|
| 7 | -278.618352 |
|
-347.821366 |
|
| 8 | -190.941702 |
|
-190.296915 |
|
| 9 | -173.731587 |
|
-169.049473 |
|
| 10 | -155.322935 |
|
-131.75116 |
|
| 11 | -145.877175 |
|
-91.63589 |
|
| 12 | -135.446439 |
|
-10.877605 |
|
| 13 | -103.744383 |
|
||
| 14 | -97.150799 |
|
||
| 15 | -75.182422 |
|
||
| 16 | -52.841934 |
|
||
| 17 | -52.19003 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -13127.008557 |
|
-19663.150709 |
|
| 2 | -2221.067488 |
|
-2972.836438 |
|
| 3 | -1855.40349 |
|
-2354.39451 |
|
| 4 | -1741.404058 |
|
-1776.172491 |
|
| 5 | -904.880551 |
|
-933.347499 |
|
| 6 | -881.843932 |
|
-746.162337 |
|
| 7 | -814.404474 |
|
-574.271278 |
|
| 8 | -665.72263 |
|
-302.154938 |
|
| 9 | -205.95821 |
|
-277.020746 |
|
| 10 | -174.920211 |
|
-169.157668 |
|
| 11 | -149.700177 |
|
-163.145155 |
|
| 12 | -125.14977 |
|
-145.080271 |
|
| 13 | -110.782631 |
|
-134.329507 |
|
| 14 | -105.359628 |
|
-123.705488 |
|
| 15 | -70.059424 |
|
||
| 16 | -67.990324 |
|
||
| 17 | -56.767656 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 2.7e-85 |
|
| 3 | 1.8e-27 |
|
| 4 | 7.6e-23 |
|
| 5 | 6.9e-31 |
|
| 6 | 3.9e-14 |
|
| 7 | 3e-09 |
|
| 8 | 0.00085 |
|
| 9 | 0.0065 |
|
| 10 | 0.0016 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 3.2e-70 |
|
2.4e-103 |
|
| 3 | 2.5e-28 |
|
3.3e-48 |
|
| 4 | 2.5e-28 |
|
1.7e-28 |
|
| 5 | 2.5e-28 |
|
2.5e-22 |
|
| 6 | 2.9e-22 |
|
3.1e-12 |
|
| 7 | 2.3e-20 |
|
15.0 |
|
| 8 | 5.6e-14 |
|
220.0 |
|
| 9 | 1.2e-14 |
|
3900.0 |
|
| 10 | 2e-05 |
|
38000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.3e-27 |
|
6.3e-85 |
|
| 3 | 3.3e-21 |
|
1.2e-25 |
|
| 4 | 1.6e-15 |
|
1.9e-23 |
|
| 5 | 7.3e-15 |
|
3.5e-14 |
|
| 6 | 6.2e-12 |
|
0.012 |
|
| 7 | 3.5e-07 |
|
15.0 |
|
| 8 | 0.12 |
|
36.0 |
|
| 9 | 0.041 |
|
670.0 |
|
| 10 | 0.18 |
|
11000.0 |
|