DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1563 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1989 |
|
| 6 | 1405 |
|
| 7 | 872 |
|
| 8 | 422 |
|
| 9 | 301 |
|
| 10 | 201 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 10164 |
|
4715 |
|
| 2 | 3061 |
|
1296 |
|
| 3 | 29 |
|
242 |
|
| 4 | 692 |
|
116 |
|
| 5 | 3 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 9927 |
|
5521 |
|
| 2 | 1699 |
|
1374 |
|
| 3 | 323 |
|
261 |
|
| 4 | 100 |
|
||
| 5 | 9 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -9155.583331 |
|
| 2 | -5672.336685 |
|
| 3 | -2121.172056 |
|
| 4 | -1529.533553 |
|
| 5 | -1247.497327 |
|
| 6 | -1230.419802 |
|
| 7 | -1071.798186 |
|
| 8 | -1005.453561 |
|
| 9 | -932.899004 |
|
| 10 | -502.7312 |
|
| 11 | -480.86608 |
|
| 12 | -311.778844 |
|
| 13 | -309.260593 |
|
| 14 | -283.415259 |
|
| 15 | -255.525263 |
|
| 16 | -237.223641 |
|
| 17 | -231.804933 |
|
| 18 | -188.29472 |
|
| 19 | -136.177609 |
|
| 20 | -134.475564 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -12964.172361 |
|
-15700.638782 |
|
| 2 | -10305.962172 |
|
-9814.223212 |
|
| 3 | -485.055519 |
|
-2161.928819 |
|
| 4 | -340.505636 |
|
-1325.856231 |
|
| 5 | -295.937093 |
|
-712.412917 |
|
| 6 | -289.989311 |
|
-329.35151 |
|
| 7 | -263.148885 |
|
-285.49971 |
|
| 8 | -252.351514 |
|
-269.306936 |
|
| 9 | -241.623933 |
|
-150.716981 |
|
| 10 | -236.029157 |
|
-107.74515 |
|
| 11 | -230.968647 |
|
-89.489636 |
|
| 12 | -225.66895 |
|
-58.427811 |
|
| 13 | -204.664932 |
|
-27.170008 |
|
| 14 | -199.464583 |
|
||
| 15 | -159.065418 |
|
||
| 16 | -60.743694 |
|
||
| 17 | -21.336011 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -13909.249171 |
|
-16962.608966 |
|
| 2 | -9754.541545 |
|
-10401.747658 |
|
| 3 | -349.990769 |
|
-2842.1577 |
|
| 4 | -278.628468 |
|
-241.783138 |
|
| 5 | -273.752277 |
|
-206.376321 |
|
| 6 | -224.179805 |
|
-165.781063 |
|
| 7 | -182.933695 |
|
-103.295745 |
|
| 8 | -162.717602 |
|
-57.333212 |
|
| 9 | -152.700347 |
|
||
| 10 | -113.905434 |
|
||
| 11 | -109.305016 |
|
||
| 12 | -93.478587 |
|
||
| 13 | -55.042951 |
|
||
| 14 | -51.4358 |
|
||
| 15 | -30.976898 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 2.6e-170 |
|
| 3 | 2.3e-44 |
|
| 4 | 6.3e-36 |
|
| 5 | 1.4e-45 |
|
| 6 | 3e-24 |
|
| 7 | 2.1e-12 |
|
| 8 | 0.00011 |
|
| 9 | 0.0012 |
|
| 10 | 0.26 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 7.1e-217 |
|
0.0 |
|
| 3 | 2.4e-59 |
|
8.9e-28 |
|
| 4 | 6.6e-14 |
|
620.0 |
|
| 5 | 9.3e-07 |
|
8000.0 |
|
| 6 | 1e-06 |
|
130000.0 |
|
| 7 | 1.4 |
|
150000.0 |
|
| 8 | 8.8 |
|
360000.0 |
|
| 9 | 12.0 |
|
970000.0 |
|
| 10 | 660.0 |
|
1800000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 0.0 |
|
0.0 |
|
| 3 | 5.3e-44 |
|
6.9e-12 |
|
| 4 | 1.5e-05 |
|
4900.0 |
|
| 5 | 0.73 |
|
270000.0 |
|
| 6 | 1.0 |
|
1200000.0 |
|
| 7 | 110.0 |
|
2300000.0 |
|
| 8 | 61000.0 |
|
3100000.0 |
|
| 9 | 130000.0 |
|
3400000.0 |
|
| 10 | 180000.0 |
|
4200000.0 |
|