DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1528 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1899 |
|
| 6 | 1147 |
|
| 7 | 812 |
|
| 8 | 421 |
|
| 9 | 230 |
|
| 10 | 153 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 5579 |
|
2837 |
|
| 2 | 2835 |
|
600 |
|
| 3 | 297 |
|
||
| 4 | 22 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 5214 |
|
2532 |
|
| 2 | 1051 |
|
712 |
|
| 3 | 213 |
|
125 |
|
| 4 | 29 |
|
||
| 5 | 3 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -6284.25558 |
|
| 2 | -5525.968735 |
|
| 3 | -859.221659 |
|
| 4 | -733.14586 |
|
| 5 | -703.084184 |
|
| 6 | -452.788345 |
|
| 7 | -403.346455 |
|
| 8 | -361.789916 |
|
| 9 | -354.545797 |
|
| 10 | -326.741507 |
|
| 11 | -242.999128 |
|
| 12 | -190.644416 |
|
| 13 | -142.63475 |
|
| 14 | -117.630426 |
|
| 15 | -115.306116 |
|
| 16 | -108.737448 |
|
| 17 | -59.719754 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -10426.205662 |
|
-11392.123589 |
|
| 2 | -6859.725532 |
|
-9241.878284 |
|
| 3 | -390.905872 |
|
-6865.934427 |
|
| 4 | -355.341138 |
|
-144.305081 |
|
| 5 | -344.441346 |
|
-131.497335 |
|
| 6 | -278.849093 |
|
-63.409242 |
|
| 7 | -251.77311 |
|
||
| 8 | -193.80645 |
|
||
| 9 | -193.80645 |
|
||
| 10 | -188.65811 |
|
||
| 11 | -178.42816 |
|
||
| 12 | -163.257817 |
|
||
| 13 | -158.249834 |
|
||
| 14 | -82.131583 |
|
||
| 15 | -74.406193 |
|
||
| 16 | -67.71612 |
|
||
| 17 | -60.027703 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -10446.565856 |
|
-11437.507141 |
|
| 2 | -5938.265884 |
|
-8031.35092 |
|
| 3 | -3844.487101 |
|
-161.598643 |
|
| 4 | -189.810473 |
|
-67.403752 |
|
| 5 | -156.232468 |
|
-61.051227 |
|
| 6 | -109.031421 |
|
-54.846537 |
|
| 7 | -60.901129 |
|
-33.372421 |
|
| 8 | -59.657573 |
|
||
| 9 | -47.322619 |
|
||
| 10 | -31.806969 |
|
||
| 11 | -17.647335 |
|
||
| 12 | -15.769554 |
|
||
| 13 | -8.507125 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 9.1e-191 |
|
| 3 | 2.1e-54 |
|
| 4 | 1.5e-31 |
|
| 5 | 9.7e-27 |
|
| 6 | 2.7e-12 |
|
| 7 | 0.0074 |
|
| 8 | 0.13 |
|
| 9 | 0.21 |
|
| 10 | 15.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 9.8e-267 |
|
0.0 |
|
| 3 | 2.3e-69 |
|
3.8e-11 |
|
| 4 | 1.9e-54 |
|
20.0 |
|
| 5 | 3.9e-27 |
|
94000.0 |
|
| 6 | 4.6e-21 |
|
550000.0 |
|
| 7 | 7e-15 |
|
1600000.0 |
|
| 8 | 2.5e-06 |
|
1700000.0 |
|
| 9 | 3.7 |
|
2000000.0 |
|
| 10 | 970.0 |
|
3300000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 5.4e-282 |
|
0.0 |
|
| 3 | 4.4e-111 |
|
0.0004 |
|
| 4 | 1.6e-51 |
|
3300000.0 |
|
| 5 | 2.6e-08 |
|
3300000.0 |
|
| 6 | 0.0016 |
|
3400000.0 |
|
| 7 | 0.23 |
|
4200000.0 |
|
| 8 | 0.42 |
|
4300000.0 |
|
| 9 | 22.0 |
|
1500000.0 |
|
| 10 | 260.0 |
|
1800000.0 |
|