DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1962 |
|
| 5 | 1213 |
|
| 6 | 614 |
|
| 7 | 340 |
|
| 8 | 219 |
|
| 9 | 184 |
|
| 10 | 129 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 9839 |
|
6003 |
|
| 2 | 1786 |
|
919 |
|
| 3 | 688 |
|
897 |
|
| 4 | 532 |
|
227 |
|
| 5 | 28 |
|
||
| 6 | 3 |
|
||
| 7 | 1 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 16379 |
|
6564 |
|
| 2 | 97 |
|
851 |
|
| 3 | 1 |
|
228 |
|
| 4 | 84 |
|
||
| 5 | 54 |
|
||
| 6 | 2 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -5637.673684 |
|
| 2 | -1998.564926 |
|
| 3 | -1436.579343 |
|
| 4 | -1316.40948 |
|
| 5 | -1138.636057 |
|
| 6 | -1093.039684 |
|
| 7 | -892.745283 |
|
| 8 | -886.270983 |
|
| 9 | -833.909637 |
|
| 10 | -820.838365 |
|
| 11 | -590.291599 |
|
| 12 | -491.279756 |
|
| 13 | -443.733684 |
|
| 14 | -413.176215 |
|
| 15 | -175.776932 |
|
| 16 | -167.568929 |
|
| 17 | -149.582369 |
|
| 18 | -58.41636 |
|
| 19 | -25.370395 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -8390.086593 |
|
-9913.871547 |
|
| 2 | -5160.609648 |
|
-7650.694758 |
|
| 3 | -2514.487484 |
|
-2061.828694 |
|
| 4 | -1776.219463 |
|
-936.123255 |
|
| 5 | -1644.242447 |
|
-803.560435 |
|
| 6 | -1261.158489 |
|
-627.793673 |
|
| 7 | -1242.503928 |
|
-368.909828 |
|
| 8 | -1175.053081 |
|
-264.019852 |
|
| 9 | -831.272634 |
|
-175.113713 |
|
| 10 | -820.012297 |
|
-92.213265 |
|
| 11 | -738.527215 |
|
-58.986353 |
|
| 12 | -678.469505 |
|
||
| 13 | -637.019316 |
|
||
| 14 | -606.126498 |
|
||
| 15 | -490.770196 |
|
||
| 16 | -483.409073 |
|
||
| 17 | -478.830479 |
|
||
| 18 | -396.783049 |
|
||
| 19 | -254.8698 |
|
||
| 20 | -106.181167 |
|
||
| 21 | -95.697686 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -9205.918235 |
|
-10926.901537 |
|
| 2 | -7057.707631 |
|
-8644.959815 |
|
| 3 | -6270.907556 |
|
-6623.033041 |
|
| 4 | -3288.605606 |
|
-1722.687231 |
|
| 5 | -1797.90001 |
|
-294.930487 |
|
| 6 | -1373.457577 |
|
-277.857121 |
|
| 7 | -609.565618 |
|
-198.718031 |
|
| 8 | -541.844889 |
|
-109.531193 |
|
| 9 | -429.459306 |
|
-85.455932 |
|
| 10 | -417.782884 |
|
-73.958159 |
|
| 11 | -415.568258 |
|
-64.49177 |
|
| 12 | -406.152933 |
|
-48.916206 |
|
| 13 | -358.424276 |
|
-13.079498 |
|
| 14 | -358.424276 |
|
||
| 15 | -246.169964 |
|
||
| 16 | -201.658345 |
|
||
| 17 | -149.977679 |
|
||
| 18 | -36.567029 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 1.8e-58 |
|
| 3 | 1.6e-55 |
|
| 4 | 2.2e-48 |
|
| 5 | 1.1e-06 |
|
| 6 | 0.049 |
|
| 7 | 0.049 |
|
| 8 | 3000.0 |
|
| 9 | 5.2 |
|
| 10 | 35.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 1.4e-218 |
|
0.0 |
|
| 2 | 1.9e-143 |
|
1.6e-219 |
|
| 3 | 9.1e-152 |
|
1.9e-104 |
|
| 4 | 3.9e-69 |
|
8.2e-77 |
|
| 5 | 4.3e-60 |
|
1.8e-44 |
|
| 6 | 6.7e-43 |
|
1.6e-16 |
|
| 7 | 2.8e-30 |
|
7.3e-15 |
|
| 8 | 5.2e-25 |
|
0.068 |
|
| 9 | 9.8e-25 |
|
0.79 |
|
| 10 | 5.3e-23 |
|
620000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 6.2e-271 |
|
0.0 |
|
| 3 | 7.6e-107 |
|
5.8e-307 |
|
| 4 | 4e-90 |
|
1.3e-87 |
|
| 5 | 1.3e-85 |
|
1.4e-27 |
|
| 6 | 1.9e-60 |
|
0.00013 |
|
| 7 | 4.2e-57 |
|
120.0 |
|
| 8 | 5.7e-26 |
|
93000.0 |
|
| 9 | 3.6e-15 |
|
240000.0 |
|
| 10 | 1.4e-15 |
|
450000.0 |
|