DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1999 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1941 |
|
| 5 | 1146 |
|
| 6 | 616 |
|
| 7 | 327 |
|
| 8 | 185 |
|
| 9 | 139 |
|
| 10 | 69 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 2647 |
|
2499 |
|
| 2 | 599 |
|
256 |
|
| 3 | 666 |
|
93 |
|
| 4 | 16 |
|
||
| 5 | 1 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 4025 |
|
1845 |
|
| 2 | 434 |
|
571 |
|
| 3 | 157 |
|
227 |
|
| 4 | 23 |
|
103 |
|
| 5 | 1 |
|
8 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -6183.603493 |
|
| 2 | -3639.167658 |
|
| 3 | -868.145022 |
|
| 4 | -401.104033 |
|
| 5 | -385.917472 |
|
| 6 | -378.078039 |
|
| 7 | -358.566168 |
|
| 8 | -251.290383 |
|
| 9 | -114.572257 |
|
| 10 | -101.464114 |
|
| 11 | -94.170321 |
|
| 12 | -90.640029 |
|
| 13 | -78.002896 |
|
| 14 | -41.075407 |
|
| 15 | -32.631543 |
|
| 16 | -21.425737 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -9889.775973 |
|
-8440.561866 |
|
| 2 | -6138.691697 |
|
-8023.522804 |
|
| 3 | -156.332604 |
|
-5466.606918 |
|
| 4 | -155.206729 |
|
-423.749234 |
|
| 5 | -117.625661 |
|
-105.249712 |
|
| 6 | -108.250669 |
|
-60.806275 |
|
| 7 | -94.447098 |
|
-1.368497 |
|
| 8 | -72.222215 |
|
||
| 9 | -69.066583 |
|
||
| 10 | -60.585144 |
|
||
| 11 | -24.301321 |
|
||
| 12 | -20.966986 |
|
||
| 13 | -17.618836 |
|
||
| 14 | -14.90493 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -10940.945224 |
|
-8780.381741 |
|
| 2 | -8254.108079 |
|
-5806.828136 |
|
| 3 | -636.568985 |
|
-3189.923902 |
|
| 4 | -499.765371 |
|
-476.732845 |
|
| 5 | -420.523068 |
|
-62.976045 |
|
| 6 | -122.926593 |
|
-42.664767 |
|
| 7 | -85.01597 |
|
-38.793697 |
|
| 8 | -76.248648 |
|
-8.319613 |
|
| 9 | -71.859457 |
|
||
| 10 | -53.97431 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 3e-217 |
|
| 3 | 2.9e-60 |
|
| 4 | 4.1e-47 |
|
| 5 | 0.00033 |
|
| 6 | 1.1 |
|
| 7 | 5.3 |
|
| 8 | 25.0 |
|
| 9 | 430.0 |
|
| 10 | 970.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1e-260 |
|
0.0 |
|
| 3 | 4.4e-142 |
|
5e-251 |
|
| 4 | 2.8e-24 |
|
4.6e-35 |
|
| 5 | 2.3e-11 |
|
71000.0 |
|
| 6 | 1.5e-05 |
|
110000.0 |
|
| 7 | 0.0023 |
|
140000.0 |
|
| 8 | 0.02 |
|
1300000.0 |
|
| 9 | 0.02 |
|
3000000.0 |
|
| 10 | 460.0 |
|
3800000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 6.1e-226 |
|
7.7e-198 |
|
| 3 | 4.6e-89 |
|
1.5e-08 |
|
| 4 | 0.085 |
|
300000.0 |
|
| 5 | 1800.0 |
|
710000.0 |
|
| 6 | 220000.0 |
|
1000000.0 |
|
| 7 | 280000.0 |
|
3500000.0 |
|
| 8 | 1100000.0 |
|
4000000.0 |
|
| 9 | 950000.0 |
|
4000000.0 |
|
| 10 | 2000000.0 |
|
3700000.0 |
|