DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1436 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1927 |
|
| 6 | 1356 |
|
| 7 | 818 |
|
| 8 | 499 |
|
| 9 | 314 |
|
| 10 | 273 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 9361 |
|
5298 |
|
| 2 | 5763 |
|
373 |
|
| 3 | 19 |
|
237 |
|
| 4 | 91 |
|
||
| 5 | 1 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 9793 |
|
5824 |
|
| 2 | 2276 |
|
1331 |
|
| 3 | 1158 |
|
405 |
|
| 4 | 547 |
|
48 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -7206.074788 |
|
| 2 | -4680.600232 |
|
| 3 | -3738.148715 |
|
| 4 | -2562.857736 |
|
| 5 | -1824.901479 |
|
| 6 | -1597.755716 |
|
| 7 | -1385.816133 |
|
| 8 | -1183.314405 |
|
| 9 | -982.688359 |
|
| 10 | -979.947483 |
|
| 11 | -927.446224 |
|
| 12 | -859.507069 |
|
| 13 | -405.067375 |
|
| 14 | -329.054044 |
|
| 15 | -304.895969 |
|
| 16 | -147.359317 |
|
| 17 | -142.720988 |
|
| 18 | -53.574405 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -12338.65354 |
|
-15678.605025 |
|
| 2 | -6836.999779 |
|
-10067.202508 |
|
| 3 | -6723.518983 |
|
-935.988027 |
|
| 4 | -1352.269961 |
|
-516.387307 |
|
| 5 | -1096.587143 |
|
-295.394361 |
|
| 6 | -1088.954403 |
|
-257.923557 |
|
| 7 | -536.893729 |
|
-75.69092 |
|
| 8 | -447.137994 |
|
-12.749744 |
|
| 9 | -373.141941 |
|
-8.405591 |
|
| 10 | -350.488312 |
|
||
| 11 | -308.682371 |
|
||
| 12 | -203.836074 |
|
||
| 13 | -198.653141 |
|
||
| 14 | -135.527228 |
|
||
| 15 | -127.952806 |
|
||
| 16 | -68.81558 |
|
||
| 17 | -24.82856 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -12194.833275 |
|
-14040.682785 |
|
| 2 | -6572.045411 |
|
-6919.363299 |
|
| 3 | -5970.094831 |
|
-5462.418762 |
|
| 4 | -1061.915697 |
|
-684.835207 |
|
| 5 | -127.454942 |
|
||
| 6 | -105.210134 |
|
||
| 7 | -102.598388 |
|
||
| 8 | -93.25996 |
|
||
| 9 | -74.912188 |
|
||
| 10 | -59.969358 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 1.3e-185 |
|
| 3 | 1.4e-40 |
|
| 4 | 7.4e-28 |
|
| 5 | 8.8e-12 |
|
| 6 | 0.31 |
|
| 7 | 0.28 |
|
| 8 | 9.9 |
|
| 9 | 140.0 |
|
| 10 | 3600.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 5.9e-184 |
|
0.0 |
|
| 3 | 7.2e-68 |
|
0.094 |
|
| 4 | 5.3e-25 |
|
0.095 |
|
| 5 | 1e-23 |
|
1.7 |
|
| 6 | 7.7e-07 |
|
680000.0 |
|
| 7 | 6.6e-06 |
|
1300000.0 |
|
| 8 | 0.0046 |
|
2900000.0 |
|
| 9 | 0.023 |
|
3700000.0 |
|
| 10 | 190.0 |
|
4100000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 7.2e-186 |
|
0.0 |
|
| 3 | 2.8e-134 |
|
1.1e-297 |
|
| 4 | 1.6e-21 |
|
5.7e-30 |
|
| 5 | 20.0 |
|
96.0 |
|
| 6 | 160.0 |
|
2900000.0 |
|
| 7 | 970.0 |
|
4900000.0 |
|
| 8 | 1900.0 |
|
5000000.0 |
|
| 9 | 2600.0 |
|
8400000.0 |
|
| 10 | 90000.0 |
|
5200000.0 |
|