DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1554 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1926 |
|
| 6 | 1134 |
|
| 7 | 510 |
|
| 8 | 386 |
|
| 9 | 150 |
|
| 10 | 56 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 6388 |
|
4601 |
|
| 2 | 1952 |
|
558 |
|
| 3 | 86 |
|
||
| 4 | 44 |
|
||
| 5 | 3 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 7184 |
|
5016 |
|
| 2 | 953 |
|
539 |
|
| 3 | 295 |
|
38 |
|
| 4 | 24 |
|
15 |
|
| 5 | 1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -8351.891742 |
|
| 2 | -3974.050425 |
|
| 3 | -1163.138866 |
|
| 4 | -627.948906 |
|
| 5 | -517.232567 |
|
| 6 | -414.532061 |
|
| 7 | -378.066171 |
|
| 8 | -212.801083 |
|
| 9 | -209.940134 |
|
| 10 | -170.437653 |
|
| 11 | -149.261092 |
|
| 12 | -136.004201 |
|
| 13 | -122.29259 |
|
| 14 | -85.489279 |
|
| 15 | -83.494302 |
|
| 16 | -53.546868 |
|
| 17 | -48.585338 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -9806.826137 |
|
-11780.804829 |
|
| 2 | -6296.073365 |
|
-7321.459628 |
|
| 3 | -410.837736 |
|
-4667.16233 |
|
| 4 | -320.471351 |
|
-299.079125 |
|
| 5 | -239.084338 |
|
-132.690099 |
|
| 6 | -238.647752 |
|
-52.522745 |
|
| 7 | -197.84077 |
|
||
| 8 | -187.042467 |
|
||
| 9 | -162.54396 |
|
||
| 10 | -156.851735 |
|
||
| 11 | -133.428352 |
|
||
| 12 | -132.387799 |
|
||
| 13 | -125.83594 |
|
||
| 14 | -85.77185 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -13221.777437 |
|
-13337.818483 |
|
| 2 | -7717.866517 |
|
-10567.704696 |
|
| 3 | -354.71634 |
|
-3893.010113 |
|
| 4 | -254.841816 |
|
-172.686365 |
|
| 5 | -216.517827 |
|
-71.978217 |
|
| 6 | -138.514341 |
|
-43.566405 |
|
| 7 | -137.090705 |
|
||
| 8 | -129.939879 |
|
||
| 9 | -51.346433 |
|
||
| 10 | -48.356814 |
|
||
| 11 | -44.186915 |
|
||
| 12 | -31.7886 |
|
||
| 13 | -13.087091 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 4.7e-314 |
|
| 3 | 4.7e-82 |
|
| 4 | 8.6e-33 |
|
| 5 | 2.3e-14 |
|
| 6 | 9.0 |
|
| 7 | 12000.0 |
|
| 8 | 250000.0 |
|
| 9 | 81000.0 |
|
| 10 | 22000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 0.0 |
|
0.0 |
|
| 3 | 8.9e-28 |
|
1.5e-12 |
|
| 4 | 5.4e-12 |
|
6100.0 |
|
| 5 | 3.6 |
|
23000.0 |
|
| 6 | 1600.0 |
|
1700000.0 |
|
| 7 | 2700.0 |
|
2500000.0 |
|
| 8 | 780.0 |
|
3100000.0 |
|
| 9 | 16000.0 |
|
3100000.0 |
|
| 10 | 79000.0 |
|
4600000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 0.0 |
|
0.0 |
|
| 3 | 0.0031 |
|
4.2 |
|
| 4 | 670.0 |
|
4.2 |
|
| 5 | 29000.0 |
|
190.0 |
|
| 6 | 610000.0 |
|
4300.0 |
|
| 7 | 1400000.0 |
|
510000.0 |
|
| 8 | 810000.0 |
|
2100000.0 |
|
| 9 | 1500000.0 |
|
2100000.0 |
|
| 10 | 1600000.0 |
|
3100000.0 |
|