DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1551 |
|
| 2 | 1188 |
|
| 3 | 1453 |
|
| 4 | 1159 |
|
| 5 | 1551 |
|
| 6 | 1548 |
|
| 7 | 1988 |
|
| 8 | 1976 |
|
| 9 | 1787 |
|
| 10 | 1670 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 5811 |
|
2963 |
|
| 2 | 1598 |
|
638 |
|
| 3 | 277 |
|
432 |
|
| 4 | 60 |
|
164 |
|
| 5 | 10 |
|
47 |
|
| 6 | 7 |
|
||
| 7 | 1 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 3928 |
|
4946 |
|
| 2 | 371 |
|
527 |
|
| 3 | 91 |
|
184 |
|
| 4 | 3 |
|
1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -2815.555086 |
|
| 2 | -2049.920873 |
|
| 3 | -1322.711025 |
|
| 4 | -1157.904217 |
|
| 5 | -828.770591 |
|
| 6 | -782.73795 |
|
| 7 | -701.203266 |
|
| 8 | -448.164019 |
|
| 9 | -439.562646 |
|
| 10 | -351.20186 |
|
| 11 | -261.581017 |
|
| 12 | -240.291798 |
|
| 13 | -190.942981 |
|
| 14 | -188.481002 |
|
| 15 | -172.593531 |
|
| 16 | -148.213265 |
|
| 17 | -127.512352 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -5843.895418 |
|
-6078.198872 |
|
| 2 | -4284.286864 |
|
-3192.892689 |
|
| 3 | -2732.766261 |
|
-1499.071637 |
|
| 4 | -1469.383859 |
|
-555.929392 |
|
| 5 | -642.950607 |
|
-543.653226 |
|
| 6 | -299.876027 |
|
-257.100755 |
|
| 7 | -289.586675 |
|
-202.249157 |
|
| 8 | -221.712871 |
|
-191.958602 |
|
| 9 | -87.276243 |
|
-114.35516 |
|
| 10 | -29.618236 |
|
||
| 11 | -12.482913 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -291.406988 |
|
-624.50309 |
|
| 2 | -222.662512 |
|
-523.396506 |
|
| 3 | -197.825745 |
|
-523.244268 |
|
| 4 | -149.162319 |
|
-496.429864 |
|
| 5 | -137.887968 |
|
-362.690343 |
|
| 6 | -129.608719 |
|
-309.579616 |
|
| 7 | -106.362431 |
|
-273.633943 |
|
| 8 | -100.573156 |
|
-230.623126 |
|
| 9 | -98.623394 |
|
-230.623126 |
|
| 10 | -84.865436 |
|
-169.770569 |
|
| 11 | -84.67732 |
|
-99.360789 |
|
| 12 | -80.11174 |
|
-83.306548 |
|
| 13 | -76.930049 |
|
-72.221327 |
|
| 14 | -76.930049 |
|
-70.460735 |
|
| 15 | -66.929349 |
|
-67.315936 |
|
| 16 | -53.532836 |
|
-14.177976 |
|
| 17 | -41.476485 |
|
||
| 18 | -35.972618 |
|
||
| 19 | -23.970585 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 3.6e-205 |
|
| 2 | 1.6e-66 |
|
| 3 | 2.4e-42 |
|
| 4 | 1.9e-35 |
|
| 5 | 9.8e-30 |
|
| 6 | 3.2e-26 |
|
| 7 | 2.9e-12 |
|
| 8 | 5.1e-09 |
|
| 9 | 6.1e-05 |
|
| 10 | 0.00068 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 3.6e-185 |
|
6.2e-229 |
|
| 3 | 1.1e-73 |
|
1.6e-65 |
|
| 4 | 1.1e-44 |
|
2.7e-13 |
|
| 5 | 2.7 |
|
3.5e-06 |
|
| 6 | 280.0 |
|
0.45 |
|
| 7 | 330.0 |
|
730000.0 |
|
| 8 | 7600.0 |
|
1400000.0 |
|
| 9 | 410.0 |
|
2100000.0 |
|
| 10 | 50000.0 |
|
2500000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 4.7e-285 |
|
1e-113 |
|
| 2 | 6.2e-209 |
|
1.4e-66 |
|
| 3 | 0.00052 |
|
1e-26 |
|
| 4 | 66.0 |
|
9.2e-19 |
|
| 5 | 2100.0 |
|
6.1e-08 |
|
| 6 | 6100.0 |
|
6.5e-08 |
|
| 7 | 21000.0 |
|
9.8e-07 |
|
| 8 | 6200.0 |
|
0.031 |
|
| 9 | 47000.0 |
|
0.11 |
|
| 10 | 63000.0 |
|
0.56 |
|