DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1462 |
|
| 2 | 1235 |
|
| 3 | 1197 |
|
| 4 | 1245 |
|
| 5 | 1973 |
|
| 6 | 1010 |
|
| 7 | 1980 |
|
| 8 | 1968 |
|
| 9 | 1633 |
|
| 10 | 1455 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 9711 |
|
4917 |
|
| 2 | 110 |
|
607 |
|
| 3 | 59 |
|
153 |
|
| 4 | 12 |
|
55 |
|
| 5 | 34 |
|
||
| 6 | 13 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 8500 |
|
2929 |
|
| 2 | 185 |
|
922 |
|
| 3 | 21 |
|
358 |
|
| 4 | 1 |
|
64 |
|
| 5 | 1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -3134.730652 |
|
| 2 | -2957.639872 |
|
| 3 | -1909.726442 |
|
| 4 | -1725.120938 |
|
| 5 | -1472.246547 |
|
| 6 | -1228.294966 |
|
| 7 | -1126.505047 |
|
| 8 | -1061.21036 |
|
| 9 | -947.633033 |
|
| 10 | -718.556834 |
|
| 11 | -642.702391 |
|
| 12 | -551.415368 |
|
| 13 | -546.550189 |
|
| 14 | -441.420651 |
|
| 15 | -353.781029 |
|
| 16 | -282.61656 |
|
| 17 | -196.048665 |
|
| 18 | -182.062885 |
|
| 19 | -128.288751 |
|
| 20 | -128.271174 |
|
| 21 | -62.615552 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -5433.567919 |
|
-5608.532528 |
|
| 2 | -5235.986132 |
|
-4509.389014 |
|
| 3 | -4383.739602 |
|
-2325.48348 |
|
| 4 | -1817.240397 |
|
-800.610007 |
|
| 5 | -1108.829201 |
|
-443.721845 |
|
| 6 | -513.162214 |
|
-301.454831 |
|
| 7 | -241.534057 |
|
-241.367603 |
|
| 8 | -124.915893 |
|
-178.72833 |
|
| 9 | -124.037713 |
|
-95.913342 |
|
| 10 | -110.569922 |
|
-62.8285 |
|
| 11 | -110.569922 |
|
||
| 12 | -82.830791 |
|
||
| 13 | -82.709405 |
|
||
| 14 | -56.041277 |
|
||
| 15 | -36.61504 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -6128.074994 |
|
-6640.075493 |
|
| 2 | -5034.100376 |
|
-3087.528004 |
|
| 3 | -4652.816383 |
|
-2689.724405 |
|
| 4 | -859.919643 |
|
-475.174246 |
|
| 5 | -548.068582 |
|
-351.426446 |
|
| 6 | -452.411042 |
|
-294.747358 |
|
| 7 | -296.453102 |
|
-260.46893 |
|
| 8 | -271.633643 |
|
-138.608965 |
|
| 9 | -209.178202 |
|
-109.509218 |
|
| 10 | -158.725898 |
|
-59.037673 |
|
| 11 | -132.486066 |
|
-28.530834 |
|
| 12 | -111.358273 |
|
||
| 13 | -0.978755 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 5.5e-214 |
|
| 2 | 5.6e-80 |
|
| 3 | 1.4e-55 |
|
| 4 | 1.9e-44 |
|
| 5 | 9.5e-37 |
|
| 6 | 1.3e-22 |
|
| 7 | 5.5e-17 |
|
| 8 | 1e-10 |
|
| 9 | 7.6e-10 |
|
| 10 | 2.6e-10 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 2.5e-310 |
|
0.0 |
|
| 2 | 1.1e-182 |
|
1e-297 |
|
| 3 | 3.9e-104 |
|
1.2e-112 |
|
| 4 | 9.3e-22 |
|
6.2e-21 |
|
| 5 | 0.0012 |
|
0.015 |
|
| 6 | 1.5 |
|
0.29 |
|
| 7 | 220.0 |
|
0.48 |
|
| 8 | 3900.0 |
|
1800000.0 |
|
| 9 | 530.0 |
|
2000000.0 |
|
| 10 | 230000.0 |
|
3600000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 2.6e-315 |
|
0.0 |
|
| 2 | 5.1e-182 |
|
5.8e-244 |
|
| 3 | 1.8e-133 |
|
2.8e-176 |
|
| 4 | 0.26 |
|
0.031 |
|
| 5 | 3.7 |
|
0.11 |
|
| 6 | 2300.0 |
|
0.93 |
|
| 7 | 3500.0 |
|
86000.0 |
|
| 8 | 40000.0 |
|
290000.0 |
|
| 9 | 160000.0 |
|
1100000.0 |
|
| 10 | 140000.0 |
|
1200000.0 |
|