DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1626 |
|
| 2 | 1004 |
|
| 3 | 1351 |
|
| 4 | 1165 |
|
| 5 | 1207 |
|
| 6 | 2000 |
|
| 7 | 1998 |
|
| 8 | 1948 |
|
| 9 | 1573 |
|
| 10 | 1091 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 7809 |
|
7905 |
|
| 2 | 3316 |
|
710 |
|
| 3 | 252 |
|
190 |
|
| 4 | 135 |
|
47 |
|
| 5 | 54 |
|
3 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 9175 |
|
6239 |
|
| 2 | 462 |
|
207 |
|
| 3 | 101 |
|
41 |
|
| 4 | 29 |
|
6 |
|
| 5 | 3 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -4283.705521 |
|
| 2 | -3575.869123 |
|
| 3 | -2416.083827 |
|
| 4 | -2160.847361 |
|
| 5 | -2129.39809 |
|
| 6 | -1049.614572 |
|
| 7 | -797.85823 |
|
| 8 | -717.67422 |
|
| 9 | -698.676541 |
|
| 10 | -482.827552 |
|
| 11 | -476.330477 |
|
| 12 | -343.764956 |
|
| 13 | -323.102878 |
|
| 14 | -313.652556 |
|
| 15 | -230.023762 |
|
| 16 | -162.513443 |
|
| 17 | -26.359025 |
|
| 18 | -19.127704 |
|
| 19 | -18.713696 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -8108.981757 |
|
-9576.79604 |
|
| 2 | -6819.265378 |
|
-5739.522146 |
|
| 3 | -5034.668565 |
|
-2342.325606 |
|
| 4 | -2892.379957 |
|
-1480.195247 |
|
| 5 | -1035.163754 |
|
-226.304285 |
|
| 6 | -399.172053 |
|
-216.104937 |
|
| 7 | -262.206749 |
|
-214.997687 |
|
| 8 | -177.200202 |
|
-138.751507 |
|
| 9 | -137.079726 |
|
-129.017312 |
|
| 10 | -111.363238 |
|
-66.623819 |
|
| 11 | -16.581571 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -13323.970287 |
|
-15727.308698 |
|
| 2 | -399.170795 |
|
-343.175315 |
|
| 3 | -235.797768 |
|
-289.992881 |
|
| 4 | -235.408267 |
|
-207.883123 |
|
| 5 | -232.069536 |
|
-187.282866 |
|
| 6 | -221.913893 |
|
-177.113516 |
|
| 7 | -209.11518 |
|
-174.188689 |
|
| 8 | -179.788488 |
|
-118.211559 |
|
| 9 | -161.937763 |
|
-90.398383 |
|
| 10 | -86.50286 |
|
-84.688967 |
|
| 11 | -77.564765 |
|
-64.013428 |
|
| 12 | -77.564765 |
|
-60.147246 |
|
| 13 | -70.125694 |
|
-59.782359 |
|
| 14 | -38.923988 |
|
-31.882864 |
|
| 15 | -25.13215 |
|
-18.617789 |
|
| 16 | -11.479512 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 3.6e-174 |
|
| 2 | 4.7e-74 |
|
| 3 | 4e-41 |
|
| 4 | 1.1e-43 |
|
| 5 | 6.3e-13 |
|
| 6 | 1.1e-10 |
|
| 7 | 1.8e-07 |
|
| 8 | 2.6e-05 |
|
| 9 | 0.013 |
|
| 10 | 9.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 5.3e-138 |
|
6.6e-250 |
|
| 3 | 8.4e-92 |
|
4e-71 |
|
| 4 | 7.6e-38 |
|
4.4e-14 |
|
| 5 | 0.0035 |
|
2.2 |
|
| 6 | 14000.0 |
|
140.0 |
|
| 7 | 24000.0 |
|
520.0 |
|
| 8 | 24000.0 |
|
280000.0 |
|
| 9 | 220000.0 |
|
3200000.0 |
|
| 10 | 230000.0 |
|
3100000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 6.2e-32 |
|
780.0 |
|
| 3 | 0.24 |
|
340000.0 |
|
| 4 | 230.0 |
|
990000.0 |
|
| 5 | 680.0 |
|
1300000.0 |
|
| 6 | 30000.0 |
|
1300000.0 |
|
| 7 | 40000.0 |
|
3200000.0 |
|
| 8 | 69000.0 |
|
3700000.0 |
|
| 9 | 130000.0 |
|
3700000.0 |
|
| 10 | 370000.0 |
|
4100000.0 |
|