DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1541 |
|
| 2 | 1246 |
|
| 3 | 1180 |
|
| 4 | 1274 |
|
| 5 | 1365 |
|
| 6 | 1320 |
|
| 7 | 1991 |
|
| 8 | 1971 |
|
| 9 | 1919 |
|
| 10 | 1242 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 6866 |
|
4448 |
|
| 2 | 1616 |
|
533 |
|
| 3 | 274 |
|
171 |
|
| 4 | 155 |
|
46 |
|
| 5 | 36 |
|
3 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 6322 |
|
4223 |
|
| 2 | 253 |
|
490 |
|
| 3 | 53 |
|
73 |
|
| 4 | 6 |
|
33 |
|
| 5 | 3 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -3129.125971 |
|
| 2 | -2341.488593 |
|
| 3 | -2137.599491 |
|
| 4 | -1734.506694 |
|
| 5 | -1396.322764 |
|
| 6 | -1197.261436 |
|
| 7 | -999.051724 |
|
| 8 | -788.353569 |
|
| 9 | -476.557419 |
|
| 10 | -396.359765 |
|
| 11 | -376.330617 |
|
| 12 | -354.34378 |
|
| 13 | -296.565553 |
|
| 14 | -253.545233 |
|
| 15 | -215.787501 |
|
| 16 | -200.036838 |
|
| 17 | -124.142193 |
|
| 18 | -105.823752 |
|
| 19 | -104.175277 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -5915.029552 |
|
-5233.104768 |
|
| 2 | -4675.518035 |
|
-5119.283676 |
|
| 3 | -3350.132956 |
|
-2256.360888 |
|
| 4 | -1637.390388 |
|
-746.661599 |
|
| 5 | -699.410154 |
|
-323.696536 |
|
| 6 | -456.994996 |
|
-224.078975 |
|
| 7 | -345.322582 |
|
-200.78493 |
|
| 8 | -258.969492 |
|
-138.797058 |
|
| 9 | -216.300554 |
|
-114.677396 |
|
| 10 | -163.620491 |
|
-95.969965 |
|
| 11 | -107.178074 |
|
-59.149705 |
|
| 12 | -55.92283 |
|
||
| 13 | -14.127513 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -5593.726637 |
|
-6122.261091 |
|
| 2 | -4835.653004 |
|
-4122.488702 |
|
| 3 | -4047.525214 |
|
-3074.149875 |
|
| 4 | -515.959068 |
|
-301.34959 |
|
| 5 | -256.456034 |
|
-133.852452 |
|
| 6 | -142.333536 |
|
-124.175963 |
|
| 7 | -126.101475 |
|
-114.623231 |
|
| 8 | -116.380113 |
|
-105.202328 |
|
| 9 | -109.625771 |
|
-93.259901 |
|
| 10 | -86.909516 |
|
-47.983878 |
|
| 11 | -47.983878 |
|
||
| 12 | -47.983878 |
|
||
| 13 | -36.097993 |
|
||
| 14 | -10.782203 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 4.9e-159 |
|
| 2 | 6.6e-84 |
|
| 3 | 7.5e-69 |
|
| 4 | 8.3e-67 |
|
| 5 | 2.2e-39 |
|
| 6 | 1.1e-38 |
|
| 7 | 9.6e-21 |
|
| 8 | 4.8e-20 |
|
| 9 | 2.7e-17 |
|
| 10 | 2.6e-10 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 3.2e-242 |
|
0.0 |
|
| 2 | 2.1e-196 |
|
0.0 |
|
| 3 | 1.8e-155 |
|
4.5e-123 |
|
| 4 | 6.4e-20 |
|
2.3e-12 |
|
| 5 | 370.0 |
|
0.35 |
|
| 6 | 1400.0 |
|
200.0 |
|
| 7 | 4400.0 |
|
63000.0 |
|
| 8 | 4500.0 |
|
200000.0 |
|
| 9 | 16000.0 |
|
640000.0 |
|
| 10 | 20000.0 |
|
2300000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 6.4e-277 |
|
1e-323 |
|
| 3 | 3.9e-130 |
|
7.9e-146 |
|
| 4 | 0.41 |
|
7.9e-10 |
|
| 5 | 21.0 |
|
270000.0 |
|
| 6 | 3500.0 |
|
350000.0 |
|
| 7 | 14000.0 |
|
500000.0 |
|
| 8 | 150000.0 |
|
790000.0 |
|
| 9 | 450000.0 |
|
1200000.0 |
|
| 10 | 1200000.0 |
|
1300000.0 |
|