DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1364 |
|
| 2 | 1232 |
|
| 3 | 1144 |
|
| 4 | 1307 |
|
| 5 | 1006 |
|
| 6 | 1554 |
|
| 7 | 1559 |
|
| 8 | 1970 |
|
| 9 | 1653 |
|
| 10 | 1978 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 5412 |
|
3130 |
|
| 2 | 1136 |
|
416 |
|
| 3 | 234 |
|
100 |
|
| 4 | 119 |
|
21 |
|
| 5 | 26 |
|
55 |
|
| 6 | 9 |
|
6 |
|
| 7 | 5 |
|
1 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 2213 |
|
2008 |
|
| 2 | 2816 |
|
472 |
|
| 3 | 74 |
|
211 |
|
| 4 | 1 |
|
74 |
|
| 5 | 16 |
|
||
| 6 | 1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -2189.651022 |
|
| 2 | -1923.279525 |
|
| 3 | -1193.020735 |
|
| 4 | -947.0242 |
|
| 5 | -829.535904 |
|
| 6 | -797.966981 |
|
| 7 | -764.870785 |
|
| 8 | -591.191967 |
|
| 9 | -420.820861 |
|
| 10 | -415.22005 |
|
| 11 | -396.595505 |
|
| 12 | -349.660323 |
|
| 13 | -235.161579 |
|
| 14 | -162.929265 |
|
| 15 | -158.556425 |
|
| 16 | -109.555692 |
|
| 17 | -86.702962 |
|
| 18 | -85.047181 |
|
| 19 | -80.418946 |
|
| 20 | -71.499696 |
|
| 21 | -61.04349 |
|
| 22 | -53.332646 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -4057.869894 |
|
-4215.833663 |
|
| 2 | -3366.873335 |
|
-3404.005157 |
|
| 3 | -2857.800952 |
|
-1209.698512 |
|
| 4 | -1254.813565 |
|
-579.722981 |
|
| 5 | -524.936954 |
|
-268.476605 |
|
| 6 | -268.365964 |
|
-186.317672 |
|
| 7 | -105.946619 |
|
-119.917743 |
|
| 8 | -105.511965 |
|
-97.00692 |
|
| 9 | -78.417418 |
|
-73.402939 |
|
| 10 | -65.231688 |
|
-59.10047 |
|
| 11 | -62.099055 |
|
-39.978672 |
|
| 12 | -52.307744 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -5051.55714 |
|
-4998.592501 |
|
| 2 | -4444.802816 |
|
-3774.943299 |
|
| 3 | -1733.548265 |
|
-972.922893 |
|
| 4 | -247.378927 |
|
-171.332425 |
|
| 5 | -242.014713 |
|
-128.842926 |
|
| 6 | -110.178711 |
|
-68.93811 |
|
| 7 | -82.517023 |
|
-66.484981 |
|
| 8 | -71.652988 |
|
-64.621931 |
|
| 9 | -69.241618 |
|
-62.721132 |
|
| 10 | -65.266854 |
|
-39.915023 |
|
| 11 | -64.911262 |
|
-25.2125 |
|
| 12 | -60.889294 |
|
-14.702064 |
|
| 13 | -51.388382 |
|
||
| 14 | -32.397637 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 2e-194 |
|
| 2 | 5.3e-76 |
|
| 3 | 4e-61 |
|
| 4 | 9.6e-54 |
|
| 5 | 9.4e-39 |
|
| 6 | 7.8e-29 |
|
| 7 | 2.7e-12 |
|
| 8 | 1.4e-08 |
|
| 9 | 0.0039 |
|
| 10 | 0.16 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 2.7e-263 |
|
0.0 |
|
| 2 | 6.7e-218 |
|
8.7e-306 |
|
| 3 | 1.9e-92 |
|
1.7e-95 |
|
| 4 | 6.7e-27 |
|
3.3e-11 |
|
| 5 | 6.8e-05 |
|
0.00048 |
|
| 6 | 3.7 |
|
5.2 |
|
| 7 | 34000.0 |
|
59000.0 |
|
| 8 | 420000.0 |
|
130000.0 |
|
| 9 | 570000.0 |
|
210000.0 |
|
| 10 | 1100000.0 |
|
310000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 0.0 |
|
0.0 |
|
| 3 | 9.4e-101 |
|
5.3e-57 |
|
| 4 | 4.8e-10 |
|
20.0 |
|
| 5 | 3.2 |
|
220000.0 |
|
| 6 | 9600.0 |
|
220000.0 |
|
| 7 | 49000.0 |
|
750000.0 |
|
| 8 | 120000.0 |
|
1300000.0 |
|
| 9 | 690000.0 |
|
1500000.0 |
|
| 10 | 640000.0 |
|
2700000.0 |
|