DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1264 |
|
| 2 | 1272 |
|
| 3 | 891 |
|
| 4 | 1367 |
|
| 5 | 1514 |
|
| 6 | 1990 |
|
| 7 | 1893 |
|
| 8 | 1565 |
|
| 9 | 1889 |
|
| 10 | 1329 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 8082 |
|
5513 |
|
| 2 | 767 |
|
971 |
|
| 3 | 311 |
|
724 |
|
| 4 | 155 |
|
88 |
|
| 5 | 6 |
|
41 |
|
| 6 | 31 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 9091 |
|
8880 |
|
| 2 | 877 |
|
1052 |
|
| 3 | 507 |
|
364 |
|
| 4 | 47 |
|
132 |
|
| 5 | 42 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -7186.968291 |
|
| 2 | -2398.668133 |
|
| 3 | -2353.427297 |
|
| 4 | -1833.186113 |
|
| 5 | -1643.277133 |
|
| 6 | -1570.310468 |
|
| 7 | -1450.839965 |
|
| 8 | -1378.396916 |
|
| 9 | -717.711935 |
|
| 10 | -542.471797 |
|
| 11 | -366.508516 |
|
| 12 | -229.934151 |
|
| 13 | -172.526442 |
|
| 14 | -116.097512 |
|
| 15 | -111.793822 |
|
| 16 | -108.635617 |
|
| 17 | -92.599178 |
|
| 18 | -88.55163 |
|
| 19 | -58.860951 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -11772.220442 |
|
-11680.191685 |
|
| 2 | -2526.359548 |
|
-3735.089194 |
|
| 3 | -812.934863 |
|
-770.63574 |
|
| 4 | -672.001693 |
|
-686.481596 |
|
| 5 | -578.183541 |
|
-611.396487 |
|
| 6 | -388.115507 |
|
-354.739926 |
|
| 7 | -356.920432 |
|
-332.308495 |
|
| 8 | -165.085189 |
|
-147.341566 |
|
| 9 | -43.39613 |
|
-130.381963 |
|
| 10 | -8.52474 |
|
-80.905845 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -13510.695977 |
|
-16048.52628 |
|
| 2 | -2372.917229 |
|
-4535.240006 |
|
| 3 | -1039.026971 |
|
-412.46003 |
|
| 4 | -231.994365 |
|
-370.460236 |
|
| 5 | -212.709587 |
|
-367.667854 |
|
| 6 | -151.650508 |
|
-297.655494 |
|
| 7 | -146.737306 |
|
-297.52983 |
|
| 8 | -85.840843 |
|
-270.615772 |
|
| 9 | -83.562636 |
|
-125.479269 |
|
| 10 | -70.087981 |
|
-102.746592 |
|
| 11 | -61.769395 |
|
-77.130064 |
|
| 12 | -61.769395 |
|
-68.011113 |
|
| 13 | -37.583043 |
|
-47.215361 |
|
| 14 | -32.780663 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 2.2e-123 |
|
| 3 | 2.8e-38 |
|
| 4 | 2.5e-29 |
|
| 5 | 4.4e-11 |
|
| 6 | 2.1e-12 |
|
| 7 | 0.12 |
|
| 8 | 0.044 |
|
| 9 | 1.0 |
|
| 10 | 0.01 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 7.4e-59 |
|
4.1e-185 |
|
| 3 | 5.4e-09 |
|
3.3e-30 |
|
| 4 | 0.0051 |
|
7e-13 |
|
| 5 | 79.0 |
|
2.5e-07 |
|
| 6 | 390.0 |
|
30.0 |
|
| 7 | 580000.0 |
|
11000.0 |
|
| 8 | 2800000.0 |
|
2600000.0 |
|
| 9 | 2800000.0 |
|
4100000.0 |
|
| 10 | 3400000.0 |
|
4300000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2.6e-54 |
|
5.8e-164 |
|
| 3 | 800000.0 |
|
9.9e-20 |
|
| 4 | 1900000.0 |
|
1700.0 |
|
| 5 | 6000000.0 |
|
8500.0 |
|
| 6 | 4500000.0 |
|
230000.0 |
|
| 7 | 8300000.0 |
|
290000.0 |
|
| 8 | 8700000.0 |
|
1800000.0 |
|
| 9 | 12000000.0 |
|
2100000.0 |
|
| 10 | 13000000.0 |
|
4000000.0 |
|