DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1442 |
|
| 2 | 1148 |
|
| 3 | 1269 |
|
| 4 | 1347 |
|
| 5 | 1179 |
|
| 6 | 1098 |
|
| 7 | 1967 |
|
| 8 | 1987 |
|
| 9 | 1943 |
|
| 10 | 1437 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 8129 |
|
6159 |
|
| 2 | 1042 |
|
470 |
|
| 3 | 50 |
|
||
| 4 | 28 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 6760 |
|
6714 |
|
| 2 | 1356 |
|
575 |
|
| 3 | 1423 |
|
465 |
|
| 4 | 192 |
|
212 |
|
| 5 | 43 |
|
7 |
|
| 6 | 7 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -2861.71916 |
|
| 2 | -2796.971807 |
|
| 3 | -2401.025614 |
|
| 4 | -2230.946872 |
|
| 5 | -2088.672993 |
|
| 6 | -1516.34557 |
|
| 7 | -1193.383276 |
|
| 8 | -1168.256924 |
|
| 9 | -1066.277094 |
|
| 10 | -792.778485 |
|
| 11 | -499.234257 |
|
| 12 | -324.590559 |
|
| 13 | -290.07229 |
|
| 14 | -142.606747 |
|
| 15 | -100.169651 |
|
| 16 | -96.0578 |
|
| 17 | -67.720001 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -6021.413202 |
|
-6683.941214 |
|
| 2 | -4206.204533 |
|
-5516.434101 |
|
| 3 | -2297.133852 |
|
-1405.154896 |
|
| 4 | -793.77273 |
|
-808.313701 |
|
| 5 | -571.70039 |
|
-679.640944 |
|
| 6 | -494.702143 |
|
-319.962218 |
|
| 7 | -300.62203 |
|
-143.549625 |
|
| 8 | -242.363684 |
|
-73.849228 |
|
| 9 | -230.28972 |
|
-66.350974 |
|
| 10 | -175.142675 |
|
-62.594579 |
|
| 11 | -162.069745 |
|
-55.217283 |
|
| 12 | -148.222873 |
|
||
| 13 | -143.295949 |
|
||
| 14 | -138.396496 |
|
||
| 15 | -109.623196 |
|
||
| 16 | -95.681637 |
|
||
| 17 | -86.574127 |
|
||
| 18 | -77.630229 |
|
||
| 19 | -28.480993 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -5617.538917 |
|
-5757.305084 |
|
| 2 | -3609.559752 |
|
-3548.327691 |
|
| 3 | -2803.534402 |
|
-3248.988046 |
|
| 4 | -2128.035857 |
|
-2207.340242 |
|
| 5 | -1522.660307 |
|
-1335.076168 |
|
| 6 | -811.283565 |
|
-770.083922 |
|
| 7 | -678.65499 |
|
-644.567659 |
|
| 8 | -98.346317 |
|
-197.321853 |
|
| 9 | -85.888266 |
|
-187.074891 |
|
| 10 | -81.423968 |
|
-94.831887 |
|
| 11 | -68.663202 |
|
||
| 12 | -34.481826 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 9.8e-194 |
|
| 2 | 3e-81 |
|
| 3 | 3.3e-49 |
|
| 4 | 3.4e-37 |
|
| 5 | 6.7e-17 |
|
| 6 | 7.3e-11 |
|
| 7 | 8.8e-14 |
|
| 8 | 5.5e-05 |
|
| 9 | 0.031 |
|
| 10 | 7.1 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2.7e-147 |
|
8.3e-290 |
|
| 3 | 2.8e-47 |
|
7.3e-57 |
|
| 4 | 1.6e-10 |
|
2.4e-08 |
|
| 5 | 3.2e-11 |
|
170.0 |
|
| 6 | 3.2e-11 |
|
19000.0 |
|
| 7 | 3.2e-11 |
|
150000.0 |
|
| 8 | 3.2e-11 |
|
270000.0 |
|
| 9 | 1e-08 |
|
280000.0 |
|
| 10 | 1.8e-07 |
|
3200000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 3.5e-114 |
|
2e-165 |
|
| 3 | 7.7e-101 |
|
2.6e-160 |
|
| 4 | 2.6e-70 |
|
3.4e-100 |
|
| 5 | 2.5e-46 |
|
1.1e-66 |
|
| 6 | 0.022 |
|
1.2e-25 |
|
| 7 | 200.0 |
|
1.2e-05 |
|
| 8 | 830.0 |
|
2800.0 |
|
| 9 | 1100000.0 |
|
5800000.0 |
|
| 10 | 3200000.0 |
|
5800000.0 |
|