DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1602 |
|
| 2 | 1347 |
|
| 3 | 1343 |
|
| 4 | 1414 |
|
| 5 | 1252 |
|
| 6 | 1363 |
|
| 7 | 1973 |
|
| 8 | 1985 |
|
| 9 | 1962 |
|
| 10 | 1493 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 7390 |
|
7953 |
|
| 2 | 2856 |
|
464 |
|
| 3 | 820 |
|
84 |
|
| 4 | 189 |
|
51 |
|
| 5 | 9 |
|
2 |
|
| 6 | 23 |
|
||
| 7 | 3 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 11616 |
|
3938 |
|
| 2 | 563 |
|
1343 |
|
| 3 | 141 |
|
441 |
|
| 4 | 73 |
|
||
| 5 | 58 |
|
||
| 6 | 2 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -5745.115138 |
|
| 2 | -5184.145372 |
|
| 3 | -2993.386669 |
|
| 4 | -2718.797049 |
|
| 5 | -2594.858567 |
|
| 6 | -2575.584914 |
|
| 7 | -2251.043305 |
|
| 8 | -1809.814035 |
|
| 9 | -1439.847371 |
|
| 10 | -1101.195185 |
|
| 11 | -1099.78688 |
|
| 12 | -977.406339 |
|
| 13 | -783.744855 |
|
| 14 | -384.59167 |
|
| 15 | -364.861572 |
|
| 16 | -160.392888 |
|
| 17 | -127.960101 |
|
| 18 | -71.388008 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -9270.804908 |
|
-9112.301719 |
|
| 2 | -7955.946395 |
|
-8540.478593 |
|
| 3 | -2144.354694 |
|
-1652.298525 |
|
| 4 | -1161.66685 |
|
-1148.01038 |
|
| 5 | -1081.695866 |
|
-476.782659 |
|
| 6 | -575.014542 |
|
-333.099992 |
|
| 7 | -383.994772 |
|
-197.765362 |
|
| 8 | -329.731883 |
|
-174.95076 |
|
| 9 | -109.340537 |
|
-90.795641 |
|
| 10 | -95.429093 |
|
-66.560963 |
|
| 11 | -35.68668 |
|
||
| 12 | -15.940075 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -9924.894398 |
|
-11641.893996 |
|
| 2 | -9004.592234 |
|
-8113.344412 |
|
| 3 | -1315.57538 |
|
-500.830647 |
|
| 4 | -885.699802 |
|
-465.18862 |
|
| 5 | -539.503603 |
|
-233.706872 |
|
| 6 | -260.494839 |
|
-230.287842 |
|
| 7 | -198.079254 |
|
-192.077962 |
|
| 8 | -197.53349 |
|
-166.749886 |
|
| 9 | -115.200869 |
|
-99.340255 |
|
| 10 | -51.682183 |
|
-47.324456 |
|
| 11 | -50.332793 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 1.3e-321 |
|
| 2 | 4.8e-107 |
|
| 3 | 2.9e-51 |
|
| 4 | 5.4e-33 |
|
| 5 | 1.2e-23 |
|
| 6 | 1.4e-09 |
|
| 7 | 2e-07 |
|
| 8 | 7.7e-05 |
|
| 9 | 0.099 |
|
| 10 | 88.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 4.1e-198 |
|
0.0 |
|
| 3 | 1.3e-41 |
|
8.6e-36 |
|
| 4 | 1.7e-18 |
|
4.2e-26 |
|
| 5 | 1.9e-08 |
|
2.9e-18 |
|
| 6 | 6300.0 |
|
2000.0 |
|
| 7 | 51000.0 |
|
370.0 |
|
| 8 | 150000.0 |
|
690000.0 |
|
| 9 | 180000.0 |
|
1400000.0 |
|
| 10 | 830000.0 |
|
3000000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 4.1e-246 |
|
0.0 |
|
| 3 | 8.2e-36 |
|
5900.0 |
|
| 4 | 5.3e-14 |
|
200000.0 |
|
| 5 | 4.3 |
|
780000.0 |
|
| 6 | 89.0 |
|
6700000.0 |
|
| 7 | 43000.0 |
|
10000000.0 |
|
| 8 | 2200000.0 |
|
10000000.0 |
|
| 9 | 470000.0 |
|
13000000.0 |
|
| 10 | 2800000.0 |
|
11000000.0 |
|