DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1497 |
|
| 2 | 830 |
|
| 3 | 1309 |
|
| 4 | 1253 |
|
| 5 | 1471 |
|
| 6 | 1982 |
|
| 7 | 1977 |
|
| 8 | 1966 |
|
| 9 | 1962 |
|
| 10 | 1374 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 10308 |
|
9875 |
|
| 2 | 2325 |
|
2903 |
|
| 3 | 876 |
|
1420 |
|
| 4 | 533 |
|
252 |
|
| 5 | 4 |
|
56 |
|
| 6 | 2 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 12919 |
|
11071 |
|
| 2 | 1336 |
|
2778 |
|
| 3 | 549 |
|
678 |
|
| 4 | 89 |
|
70 |
|
| 5 | 65 |
|
48 |
|
| 6 | 6 |
|
13 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -12515.655767 |
|
| 2 | -8670.480638 |
|
| 3 | -5248.132635 |
|
| 4 | -4392.299408 |
|
| 5 | -3669.327464 |
|
| 6 | -3548.852007 |
|
| 7 | -3203.803609 |
|
| 8 | -2963.43692 |
|
| 9 | -2228.113595 |
|
| 10 | -1981.461849 |
|
| 11 | -1695.18201 |
|
| 12 | -1369.965918 |
|
| 13 | -796.381202 |
|
| 14 | -462.664715 |
|
| 15 | -167.848262 |
|
| 16 | -126.304497 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -14375.43742 |
|
-21788.4985 |
|
| 2 | -7909.219401 |
|
-13883.286926 |
|
| 3 | -1975.943399 |
|
-1624.0546 |
|
| 4 | -1513.841336 |
|
-1300.462924 |
|
| 5 | -1267.247037 |
|
-974.557444 |
|
| 6 | -1178.319398 |
|
-884.636051 |
|
| 7 | -592.219112 |
|
-595.204888 |
|
| 8 | -353.150026 |
|
-539.813227 |
|
| 9 | -138.76808 |
|
-250.913143 |
|
| 10 | -134.848212 |
|
-118.406445 |
|
| 11 | -114.001223 |
|
-69.914537 |
|
| 12 | -82.597937 |
|
||
| 13 | -79.123936 |
|
||
| 14 | -32.461948 |
|
||
| 15 | -14.624188 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -13825.305498 |
|
-23351.313803 |
|
| 2 | -8119.949981 |
|
-15362.427676 |
|
| 3 | -1556.596965 |
|
-1954.780511 |
|
| 4 | -939.781892 |
|
-694.147654 |
|
| 5 | -747.941204 |
|
-672.799199 |
|
| 6 | -278.350374 |
|
-316.904914 |
|
| 7 | -236.780996 |
|
-167.112266 |
|
| 8 | -213.766299 |
|
-79.188785 |
|
| 9 | -171.440258 |
|
-69.580872 |
|
| 10 | -162.238104 |
|
-34.024492 |
|
| 11 | -131.826331 |
|
||
| 12 | -120.065178 |
|
||
| 13 | -105.826682 |
|
||
| 14 | -54.985076 |
|
||
| 15 | -37.505971 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 5.6e-321 |
|
| 2 | 6.2e-71 |
|
| 3 | 4.3e-45 |
|
| 4 | 3e-33 |
|
| 5 | 5.4e-14 |
|
| 6 | 7.6e-11 |
|
| 7 | 3.5e-06 |
|
| 8 | 4.4e-15 |
|
| 9 | 42.0 |
|
| 10 | 16.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 7e-150 |
|
1.3e-216 |
|
| 3 | 7.8e-33 |
|
0.00052 |
|
| 4 | 0.00024 |
|
0.0064 |
|
| 5 | 12000.0 |
|
1200.0 |
|
| 6 | 50000.0 |
|
760000.0 |
|
| 7 | 7200.0 |
|
2400000.0 |
|
| 8 | 810000.0 |
|
2900000.0 |
|
| 9 | 1400000.0 |
|
3900000.0 |
|
| 10 | 3000000.0 |
|
5600000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 7.9e-173 |
|
3e-296 |
|
| 3 | 1.6e-27 |
|
0.00023 |
|
| 4 | 69000.0 |
|
0.024 |
|
| 5 | 87000.0 |
|
28000.0 |
|
| 6 | 170000.0 |
|
60000.0 |
|
| 7 | 230000.0 |
|
5300000.0 |
|
| 8 | 1100000.0 |
|
5600000.0 |
|
| 9 | 3300000.0 |
|
5600000.0 |
|
| 10 | 2800000.0 |
|
5700000.0 |
|