DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1563 |
|
| 2 | 1270 |
|
| 3 | 1484 |
|
| 4 | 1053 |
|
| 5 | 1200 |
|
| 6 | 975 |
|
| 7 | 1984 |
|
| 8 | 1993 |
|
| 9 | 1955 |
|
| 10 | 1951 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 13118 |
|
11363 |
|
| 2 | 764 |
|
1016 |
|
| 3 | 187 |
|
335 |
|
| 4 | 83 |
|
24 |
|
| 5 | 31 |
|
18 |
|
| 6 | 2 |
|
1 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 13249 |
|
13387 |
|
| 2 | 1798 |
|
725 |
|
| 3 | 415 |
|
166 |
|
| 4 | 127 |
|
40 |
|
| 5 | 58 |
|
14 |
|
| 6 | 23 |
|
6 |
|
| 7 | 2 |
|
1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -7135.19178 |
|
| 2 | -6388.83732 |
|
| 3 | -3642.65872 |
|
| 4 | -2673.250841 |
|
| 5 | -2578.909878 |
|
| 6 | -2374.821526 |
|
| 7 | -2227.397256 |
|
| 8 | -2133.976795 |
|
| 9 | -1566.415448 |
|
| 10 | -1099.116245 |
|
| 11 | -922.343232 |
|
| 12 | -739.433867 |
|
| 13 | -661.091492 |
|
| 14 | -538.708705 |
|
| 15 | -225.140805 |
|
| 16 | -190.419245 |
|
| 17 | -178.531379 |
|
| 18 | -178.023017 |
|
| 19 | -122.646912 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -9096.660679 |
|
-14123.82969 |
|
| 2 | -8090.610661 |
|
-9169.013507 |
|
| 3 | -3970.057226 |
|
-3511.642407 |
|
| 4 | -2460.293965 |
|
-2361.201618 |
|
| 5 | -674.707703 |
|
-555.386525 |
|
| 6 | -316.027473 |
|
-507.578442 |
|
| 7 | -228.030659 |
|
-496.506945 |
|
| 8 | -174.342583 |
|
-375.519784 |
|
| 9 | -167.303172 |
|
-173.606164 |
|
| 10 | -11.704585 |
|
-100.527781 |
|
| 11 | -90.031078 |
|
||
| 12 | -86.783399 |
|
||
| 13 | -73.677671 |
|
||
| 14 | -73.407493 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -10915.665045 |
|
-16289.6339 |
|
| 2 | -8727.119024 |
|
-11083.71215 |
|
| 3 | -3745.136474 |
|
-2753.10407 |
|
| 4 | -3175.732945 |
|
-2028.516287 |
|
| 5 | -1449.361581 |
|
-394.844923 |
|
| 6 | -637.656347 |
|
-184.937498 |
|
| 7 | -353.9726 |
|
-180.376536 |
|
| 8 | -296.441795 |
|
-168.431588 |
|
| 9 | -269.107106 |
|
-163.39633 |
|
| 10 | -236.768435 |
|
-138.604153 |
|
| 11 | -115.160135 |
|
-131.854756 |
|
| 12 | -86.402695 |
|
-65.021782 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 6.5e-189 |
|
| 2 | 3.3e-69 |
|
| 3 | 1.6e-56 |
|
| 4 | 2e-30 |
|
| 5 | 7e-29 |
|
| 6 | 9.8e-24 |
|
| 7 | 3.1e-17 |
|
| 8 | 4.4e-15 |
|
| 9 | 1e-08 |
|
| 10 | 0.0031 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.8e-206 |
|
2.3e-274 |
|
| 3 | 2.6e-45 |
|
4.1e-49 |
|
| 4 | 1.6e-25 |
|
2.9e-20 |
|
| 5 | 8.5e-06 |
|
3.5e-07 |
|
| 6 | 11000.0 |
|
1.2e-06 |
|
| 7 | 9000.0 |
|
5700.0 |
|
| 8 | 50000.0 |
|
30000.0 |
|
| 9 | 87000.0 |
|
88000.0 |
|
| 10 | 1100000.0 |
|
230000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 2.6e-313 |
|
0.0 |
|
| 2 | 4e-160 |
|
0.0 |
|
| 3 | 8.6e-22 |
|
2.4e-45 |
|
| 4 | 1.4e-11 |
|
1.8e-16 |
|
| 5 | 0.78 |
|
0.0013 |
|
| 6 | 3000.0 |
|
76.0 |
|
| 7 | 31000.0 |
|
1300.0 |
|
| 8 | 94000.0 |
|
24000.0 |
|
| 9 | 250000.0 |
|
38000.0 |
|
| 10 | 540000.0 |
|
46000.0 |
|