DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1635 |
|
| 2 | 1296 |
|
| 3 | 1440 |
|
| 4 | 952 |
|
| 5 | 1270 |
|
| 6 | 1350 |
|
| 7 | 1240 |
|
| 8 | 1995 |
|
| 9 | 2000 |
|
| 10 | 1939 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 11150 |
|
7026 |
|
| 2 | 650 |
|
1344 |
|
| 3 | 153 |
|
1248 |
|
| 4 | 34 |
|
154 |
|
| 5 | 17 |
|
||
| 6 | 5 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 12777 |
|
8865 |
|
| 2 | 891 |
|
1288 |
|
| 3 | 304 |
|
240 |
|
| 4 | 39 |
|
50 |
|
| 5 | 21 |
|
60 |
|
| 6 | 17 |
|
||
| 7 | 1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -6685.751381 |
|
| 2 | -5514.447682 |
|
| 3 | -3682.904347 |
|
| 4 | -2527.549718 |
|
| 5 | -2229.133146 |
|
| 6 | -1728.747876 |
|
| 7 | -1669.660741 |
|
| 8 | -1071.611408 |
|
| 9 | -849.717191 |
|
| 10 | -845.278202 |
|
| 11 | -737.884612 |
|
| 12 | -586.972716 |
|
| 13 | -535.718235 |
|
| 14 | -465.211263 |
|
| 15 | -318.141141 |
|
| 16 | -246.061079 |
|
| 17 | -225.317651 |
|
| 18 | -129.36832 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -8333.554621 |
|
-13128.93511 |
|
| 2 | -8113.611007 |
|
-9150.289947 |
|
| 3 | -4317.501956 |
|
-3462.150709 |
|
| 4 | -3245.019871 |
|
-2216.572462 |
|
| 5 | -562.774974 |
|
-268.48051 |
|
| 6 | -384.359604 |
|
-185.089245 |
|
| 7 | -242.648196 |
|
-123.884567 |
|
| 8 | -238.337972 |
|
-101.967112 |
|
| 9 | -216.381391 |
|
-98.025662 |
|
| 10 | -144.444746 |
|
-95.820967 |
|
| 11 | -135.607306 |
|
-84.03157 |
|
| 12 | -113.87141 |
|
||
| 13 | -107.106604 |
|
||
| 14 | -13.001758 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -10924.812681 |
|
-15202.831453 |
|
| 2 | -6166.374155 |
|
-5135.480156 |
|
| 3 | -2917.608237 |
|
-3212.107745 |
|
| 4 | -2856.119402 |
|
-1053.631864 |
|
| 5 | -874.226576 |
|
-519.483458 |
|
| 6 | -427.616062 |
|
-317.236352 |
|
| 7 | -149.834043 |
|
-219.739496 |
|
| 8 | -139.263196 |
|
-158.163208 |
|
| 9 | -139.263196 |
|
-155.955109 |
|
| 10 | -115.084313 |
|
-112.58903 |
|
| 11 | -90.494822 |
|
-112.357112 |
|
| 12 | -77.651211 |
|
-106.077239 |
|
| 13 | -54.473005 |
|
-101.957247 |
|
| 14 | -34.733508 |
|
-66.401765 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 1.6e-131 |
|
| 2 | 1.1e-61 |
|
| 3 | 1.4e-49 |
|
| 4 | 2.8e-21 |
|
| 5 | 1.2e-15 |
|
| 6 | 2.1e-13 |
|
| 7 | 5.7e-11 |
|
| 8 | 2.5e-11 |
|
| 9 | 0.00034 |
|
| 10 | 0.011 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2.3e-178 |
|
2e-257 |
|
| 3 | 3.1e-57 |
|
1.4e-64 |
|
| 4 | 1.1e-19 |
|
2.5e-18 |
|
| 5 | 0.69 |
|
460.0 |
|
| 6 | 93.0 |
|
260000.0 |
|
| 7 | 660.0 |
|
270000.0 |
|
| 8 | 6500.0 |
|
680000.0 |
|
| 9 | 150000.0 |
|
480000.0 |
|
| 10 | 110000.0 |
|
790000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 4.6e-147 |
|
8.4e-139 |
|
| 3 | 1.2e-67 |
|
7.4e-54 |
|
| 4 | 1.4e-25 |
|
6.5e-19 |
|
| 5 | 8.3e-13 |
|
0.72 |
|
| 6 | 2100.0 |
|
3900.0 |
|
| 7 | 34000.0 |
|
270000.0 |
|
| 8 | 940000.0 |
|
920000.0 |
|
| 9 | 1300000.0 |
|
2600000.0 |
|
| 10 | 2000000.0 |
|
4000000.0 |
|