DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1570 |
|
| 2 | 1333 |
|
| 3 | 1391 |
|
| 4 | 1759 |
|
| 5 | 1997 |
|
| 6 | 1965 |
|
| 7 | 1817 |
|
| 8 | 1767 |
|
| 9 | 1447 |
|
| 10 | 873 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 8136 |
|
4019 |
|
| 2 | 131 |
|
515 |
|
| 3 | 58 |
|
189 |
|
| 4 | 3 |
|
56 |
|
| 5 | 24 |
|
||
| 6 | 1 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 7026 |
|
3388 |
|
| 2 | 665 |
|
840 |
|
| 3 | 177 |
|
207 |
|
| 4 | 89 |
|
23 |
|
| 5 | 23 |
|
3 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -2569.61135 |
|
| 2 | -2374.952799 |
|
| 3 | -1617.541334 |
|
| 4 | -1311.206354 |
|
| 5 | -1283.775113 |
|
| 6 | -1054.606415 |
|
| 7 | -998.341379 |
|
| 8 | -857.164971 |
|
| 9 | -838.496262 |
|
| 10 | -673.994159 |
|
| 11 | -532.627733 |
|
| 12 | -420.090907 |
|
| 13 | -416.073293 |
|
| 14 | -364.228086 |
|
| 15 | -287.555543 |
|
| 16 | -203.549066 |
|
| 17 | -187.271541 |
|
| 18 | -107.507806 |
|
| 19 | -61.261476 |
|
| 20 | -3.082812 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -5248.359455 |
|
-5697.964424 |
|
| 2 | -4271.798017 |
|
-4512.245003 |
|
| 3 | -2646.535613 |
|
-2115.722424 |
|
| 4 | -1483.331069 |
|
-675.03839 |
|
| 5 | -858.935327 |
|
-368.73505 |
|
| 6 | -377.022795 |
|
-260.201983 |
|
| 7 | -302.312948 |
|
-236.164427 |
|
| 8 | -271.480963 |
|
-133.854847 |
|
| 9 | -125.491217 |
|
-63.759522 |
|
| 10 | -88.864688 |
|
-20.198487 |
|
| 11 | -19.119999 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -6583.987375 |
|
-7286.974475 |
|
| 2 | -3093.378184 |
|
-2490.377785 |
|
| 3 | -2655.048312 |
|
-1765.227688 |
|
| 4 | -821.507913 |
|
-683.719671 |
|
| 5 | -429.660527 |
|
-408.422147 |
|
| 6 | -286.251761 |
|
-268.481025 |
|
| 7 | -212.349433 |
|
-135.847183 |
|
| 8 | -205.317604 |
|
-123.980085 |
|
| 9 | -136.757568 |
|
-109.718021 |
|
| 10 | -111.106284 |
|
-95.762944 |
|
| 11 | -110.383942 |
|
-68.921275 |
|
| 12 | -98.669104 |
|
-51.982853 |
|
| 13 | -94.585725 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 9.7e-181 |
|
| 2 | 1.5e-82 |
|
| 3 | 7e-56 |
|
| 4 | 1.6e-41 |
|
| 5 | 5.9e-36 |
|
| 6 | 1e-30 |
|
| 7 | 1.4e-27 |
|
| 8 | 2.1e-11 |
|
| 9 | 9.3e-11 |
|
| 10 | 6.3e-07 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 4.3e-299 |
|
0.0 |
|
| 2 | 6e-182 |
|
0.0 |
|
| 3 | 2.9e-118 |
|
7.2e-82 |
|
| 4 | 2.4e-30 |
|
8.7e-14 |
|
| 5 | 0.051 |
|
12000.0 |
|
| 6 | 83.0 |
|
72000.0 |
|
| 7 | 970.0 |
|
240000.0 |
|
| 8 | 2900.0 |
|
670000.0 |
|
| 9 | 49000.0 |
|
730000.0 |
|
| 10 | 76000.0 |
|
1200000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 4.4e-163 |
|
7.4e-131 |
|
| 3 | 1.5e-126 |
|
1.7e-39 |
|
| 4 | 1.7e-10 |
|
0.00032 |
|
| 5 | 4.8e-08 |
|
0.00023 |
|
| 6 | 340.0 |
|
1800.0 |
|
| 7 | 1900.0 |
|
3500.0 |
|
| 8 | 30000.0 |
|
6700.0 |
|
| 9 | 330000.0 |
|
180000.0 |
|
| 10 | 370000.0 |
|
1600000.0 |
|