DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1575 |
|
| 2 | 1107 |
|
| 3 | 1110 |
|
| 4 | 1283 |
|
| 5 | 1581 |
|
| 6 | 1255 |
|
| 7 | 1268 |
|
| 8 | 1167 |
|
| 9 | 1274 |
|
| 10 | 1984 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 9287 |
|
5026 |
|
| 2 | 229 |
|
539 |
|
| 3 | 9 |
|
245 |
|
| 4 | 32 |
|
||
| 5 | 5 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 8659 |
|
3802 |
|
| 2 | 248 |
|
743 |
|
| 3 | 268 |
|
360 |
|
| 4 | 38 |
|
85 |
|
| 5 | 3 |
|
27 |
|
| 6 | 8 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -2839.724769 |
|
| 2 | -2710.250582 |
|
| 3 | -1521.985422 |
|
| 4 | -1347.496723 |
|
| 5 | -1012.422382 |
|
| 6 | -895.081994 |
|
| 7 | -884.962506 |
|
| 8 | -798.794877 |
|
| 9 | -737.501789 |
|
| 10 | -532.132036 |
|
| 11 | -453.39545 |
|
| 12 | -337.107229 |
|
| 13 | -318.434563 |
|
| 14 | -299.52505 |
|
| 15 | -218.480476 |
|
| 16 | -166.658244 |
|
| 17 | -155.124719 |
|
| 18 | -150.831717 |
|
| 19 | -148.955006 |
|
| 20 | -16.915611 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -5589.71244 |
|
-6386.587776 |
|
| 2 | -5460.70196 |
|
-4402.210245 |
|
| 3 | -4041.890653 |
|
-2088.926965 |
|
| 4 | -1760.266452 |
|
-863.229337 |
|
| 5 | -968.680255 |
|
-391.123293 |
|
| 6 | -475.289996 |
|
-385.692898 |
|
| 7 | -178.902079 |
|
-287.98624 |
|
| 8 | -147.896226 |
|
||
| 9 | -106.042067 |
|
||
| 10 | -103.199893 |
|
||
| 11 | -23.633119 |
|
||
| 12 | -4.153308 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -7375.45219 |
|
-8049.841639 |
|
| 2 | -5989.914231 |
|
-3363.596428 |
|
| 3 | -5081.140233 |
|
-1864.288492 |
|
| 4 | -634.179813 |
|
-323.570251 |
|
| 5 | -291.805691 |
|
-128.991549 |
|
| 6 | -276.926427 |
|
-118.941959 |
|
| 7 | -205.684159 |
|
-114.616275 |
|
| 8 | -200.101369 |
|
-86.788664 |
|
| 9 | -168.137545 |
|
-77.824848 |
|
| 10 | -154.471209 |
|
-51.801763 |
|
| 11 | -139.588422 |
|
-36.095241 |
|
| 12 | -108.527775 |
|
-28.563333 |
|
| 13 | -94.817028 |
|
-18.008084 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 2.3e-189 |
|
| 2 | 2.7e-66 |
|
| 3 | 2.8e-48 |
|
| 4 | 2.6e-29 |
|
| 5 | 2.4e-26 |
|
| 6 | 9.3e-29 |
|
| 7 | 3.8e-15 |
|
| 8 | 3.9e-15 |
|
| 9 | 0.00031 |
|
| 10 | 0.00052 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 1.8e-256 |
|
0.0 |
|
| 2 | 2.4e-184 |
|
5e-274 |
|
| 3 | 3.2e-94 |
|
8.5e-130 |
|
| 4 | 4.9e-29 |
|
6.2e-20 |
|
| 5 | 0.028 |
|
1.8e-13 |
|
| 6 | 11000.0 |
|
0.19 |
|
| 7 | 11000.0 |
|
1200.0 |
|
| 8 | 31000.0 |
|
23000.0 |
|
| 9 | 37000.0 |
|
33000.0 |
|
| 10 | 230000.0 |
|
75000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 2.9e-290 |
|
0.0 |
|
| 2 | 2.6e-223 |
|
3.8e-192 |
|
| 3 | 6e-103 |
|
2.4e-48 |
|
| 4 | 0.19 |
|
1.9e-23 |
|
| 5 | 490.0 |
|
590.0 |
|
| 6 | 1800.0 |
|
1200000.0 |
|
| 7 | 54000.0 |
|
1500000.0 |
|
| 8 | 99000.0 |
|
3500000.0 |
|
| 9 | 670000.0 |
|
3600000.0 |
|
| 10 | 800000.0 |
|
4800000.0 |
|