DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1052 |
|
| 2 | 1474 |
|
| 3 | 1205 |
|
| 4 | 1259 |
|
| 5 | 1620 |
|
| 6 | 1451 |
|
| 7 | 1939 |
|
| 8 | 1963 |
|
| 9 | 1881 |
|
| 10 | 882 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 1367 |
|
743 |
|
| 2 | 771 |
|
412 |
|
| 3 | 353 |
|
127 |
|
| 4 | 70 |
|
40 |
|
| 5 | 2 |
|
1 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 1204 |
|
1224 |
|
| 2 | 235 |
|
301 |
|
| 3 | 22 |
|
12 |
|
| 4 | 1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -982.122544 |
|
| 2 | -567.129669 |
|
| 3 | -499.761183 |
|
| 4 | -409.290433 |
|
| 5 | -385.975565 |
|
| 6 | -284.036455 |
|
| 7 | -248.807548 |
|
| 8 | -181.672727 |
|
| 9 | -170.802463 |
|
| 10 | -170.76131 |
|
| 11 | -159.416808 |
|
| 12 | -140.741653 |
|
| 13 | -129.932115 |
|
| 14 | -81.825023 |
|
| 15 | -65.101828 |
|
| 16 | -52.459704 |
|
| 17 | -50.506062 |
|
| 18 | -46.589029 |
|
| 19 | -42.895921 |
|
| 20 | -41.433934 |
|
| 21 | -40.711956 |
|
| 22 | -31.451889 |
|
| 23 | -26.913014 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -1697.436618 |
|
-1595.283747 |
|
| 2 | -713.751689 |
|
-852.126851 |
|
| 3 | -425.82773 |
|
-368.637113 |
|
| 4 | -414.157739 |
|
-362.92872 |
|
| 5 | -319.371263 |
|
-214.597544 |
|
| 6 | -284.769181 |
|
-163.138461 |
|
| 7 | -129.16771 |
|
-148.788003 |
|
| 8 | -105.662083 |
|
||
| 9 | -96.344967 |
|
||
| 10 | -91.742786 |
|
||
| 11 | -62.699803 |
|
||
| 12 | -55.503202 |
|
||
| 13 | -44.965115 |
|
||
| 14 | -35.240916 |
|
||
| 15 | -35.240916 |
|
||
| 16 | -34.70367 |
|
||
| 17 | -29.718121 |
|
||
| 18 | -15.70421 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -91.214787 |
|
-107.637503 |
|
| 2 | -80.15295 |
|
-94.520167 |
|
| 3 | -77.319159 |
|
-66.442118 |
|
| 4 | -57.378017 |
|
-49.109607 |
|
| 5 | -53.1041 |
|
-44.634734 |
|
| 6 | -46.611527 |
|
-44.634734 |
|
| 7 | -45.307536 |
|
-40.619424 |
|
| 8 | -39.676488 |
|
-38.558637 |
|
| 9 | -38.809989 |
|
-37.311805 |
|
| 10 | -36.513924 |
|
-37.207106 |
|
| 11 | -33.343626 |
|
-27.624514 |
|
| 12 | -26.176896 |
|
-22.342533 |
|
| 13 | -22.172938 |
|
-18.261804 |
|
| 14 | -21.341797 |
|
-16.867176 |
|
| 15 | -19.772473 |
|
-15.804633 |
|
| 16 | -17.070349 |
|
-14.508918 |
|
| 17 | -15.298287 |
|
||
| 18 | -10.247972 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 2.4e-143 |
|
| 2 | 2e-107 |
|
| 3 | 5.8e-73 |
|
| 4 | 8.4e-28 |
|
| 5 | 6.2e-14 |
|
| 6 | 8.6e-13 |
|
| 7 | 4.5e-12 |
|
| 8 | 0.0049 |
|
| 9 | 0.0034 |
|
| 10 | 22.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 6.2e-299 |
|
0.0 |
|
| 2 | 2.2e-141 |
|
0.0 |
|
| 3 | 1.4e-45 |
|
2.5e-59 |
|
| 4 | 1e-25 |
|
2.6e-37 |
|
| 5 | 2.5e-13 |
|
6.7e-21 |
|
| 6 | 9.9e-13 |
|
7.8e-18 |
|
| 7 | 0.0016 |
|
7300.0 |
|
| 8 | 3.1 |
|
2000000.0 |
|
| 9 | 93.0 |
|
2300000.0 |
|
| 10 | 5600.0 |
|
1100000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 4.9e-83 |
|
5.8e-154 |
|
| 2 | 1.4e-39 |
|
7.4e-10 |
|
| 3 | 2.2e-16 |
|
0.22 |
|
| 4 | 3.9 |
|
7.2 |
|
| 5 | 8.1 |
|
5100.0 |
|
| 6 | 71.0 |
|
3100.0 |
|
| 7 | 37.0 |
|
22000.0 |
|
| 8 | 87.0 |
|
26000.0 |
|
| 9 | 1300.0 |
|
51000.0 |
|
| 10 | 150.0 |
|
1600.0 |
|