DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1999 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1998 |
|
| 5 | 1833 |
|
| 6 | 1340 |
|
| 7 | 541 |
|
| 8 | 327 |
|
| 9 | 207 |
|
| 10 | 176 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 11850 |
|
10912 |
|
| 2 | 2710 |
|
3982 |
|
| 3 | 915 |
|
227 |
|
| 4 | 1 |
|
102 |
|
| 5 | 7 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 11049 |
|
10314 |
|
| 2 | 2065 |
|
2711 |
|
| 3 | 505 |
|
1097 |
|
| 4 | 445 |
|
877 |
|
| 5 | 1 |
|
422 |
|
| 6 | 3 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -5154.837915 |
|
| 2 | -4749.223098 |
|
| 3 | -4183.750532 |
|
| 4 | -3681.138665 |
|
| 5 | -3357.255639 |
|
| 6 | -3179.144002 |
|
| 7 | -2022.199043 |
|
| 8 | -1999.159528 |
|
| 9 | -1961.068019 |
|
| 10 | -1951.301945 |
|
| 11 | -1313.417805 |
|
| 12 | -1166.675944 |
|
| 13 | -1070.158705 |
|
| 14 | -890.521715 |
|
| 15 | -687.05498 |
|
| 16 | -468.669203 |
|
| 17 | -425.866002 |
|
| 18 | -323.307054 |
|
| 19 | -294.517965 |
|
| 20 | -241.675324 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -12966.728977 |
|
-16510.0749 |
|
| 2 | -3522.318751 |
|
-3666.744597 |
|
| 3 | -1685.793163 |
|
-1389.624588 |
|
| 4 | -665.638052 |
|
-1157.387363 |
|
| 5 | -548.636963 |
|
-609.659695 |
|
| 6 | -296.985965 |
|
-392.30636 |
|
| 7 | -274.346522 |
|
-294.775059 |
|
| 8 | -244.479911 |
|
-177.07971 |
|
| 9 | -239.091051 |
|
-174.45938 |
|
| 10 | -206.266232 |
|
-102.756348 |
|
| 11 | -181.110288 |
|
-92.405309 |
|
| 12 | -88.1301 |
|
-89.680226 |
|
| 13 | -79.588061 |
|
-60.814937 |
|
| 14 | -76.480896 |
|
||
| 15 | -50.743405 |
|
||
| 16 | -40.713468 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -10186.069867 |
|
-13714.36285 |
|
| 2 | -3772.297886 |
|
-5935.82599 |
|
| 3 | -2232.064242 |
|
-3259.942859 |
|
| 4 | -1343.79196 |
|
-1993.880269 |
|
| 5 | -1227.480542 |
|
-1545.380375 |
|
| 6 | -901.082601 |
|
-1430.675523 |
|
| 7 | -894.03948 |
|
-904.748849 |
|
| 8 | -533.673255 |
|
-875.330301 |
|
| 9 | -495.068362 |
|
-366.362505 |
|
| 10 | -362.495081 |
|
-357.840848 |
|
| 11 | -276.196189 |
|
-287.593806 |
|
| 12 | -261.791184 |
|
-133.942306 |
|
| 13 | -78.015358 |
|
-57.022181 |
|
| 14 | -39.862965 |
|
||
| 15 | -6.069506 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 2.2e-49 |
|
| 2 | 6.9e-33 |
|
| 3 | 1.2e-20 |
|
| 4 | 1.4e-19 |
|
| 5 | 2.5e-18 |
|
| 6 | 1.2e-15 |
|
| 7 | 9.1e-07 |
|
| 8 | 9.3e-11 |
|
| 9 | 1.1e-06 |
|
| 10 | 0.021 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 8.9e-77 |
|
8.4e-113 |
|
| 3 | 3.8e-33 |
|
2e-20 |
|
| 4 | 8.3e-21 |
|
9.3e-13 |
|
| 5 | 6.9e-06 |
|
82.0 |
|
| 6 | 270.0 |
|
410.0 |
|
| 7 | 890.0 |
|
12000.0 |
|
| 8 | 24000.0 |
|
440000.0 |
|
| 9 | 31000.0 |
|
460000.0 |
|
| 10 | 31000.0 |
|
770000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 4.9e-270 |
|
0.0 |
|
| 2 | 9e-89 |
|
1.3e-134 |
|
| 3 | 1.9e-62 |
|
3.1e-61 |
|
| 4 | 1.3e-20 |
|
7.3e-25 |
|
| 5 | 2.3e-11 |
|
2.1e-21 |
|
| 6 | 2.1e-09 |
|
8.5e-17 |
|
| 7 | 0.0084 |
|
2.2e-11 |
|
| 8 | 0.065 |
|
2.1e-11 |
|
| 9 | 0.31 |
|
1.2e-06 |
|
| 10 | 67.0 |
|
0.0015 |
|