DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1994 |
|
| 5 | 1744 |
|
| 6 | 848 |
|
| 7 | 365 |
|
| 8 | 142 |
|
| 9 | 71 |
|
| 10 | 59 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 7626 |
|
9410 |
|
| 2 | 3652 |
|
4010 |
|
| 3 | 1083 |
|
669 |
|
| 4 | 92 |
|
||
| 5 | 35 |
|
||
| 6 | 11 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 12893 |
|
14682 |
|
| 2 | 1025 |
|
536 |
|
| 3 | 333 |
|
8 |
|
| 4 | 18 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -5570.274023 |
|
| 2 | -5196.928741 |
|
| 3 | -4783.488304 |
|
| 4 | -3864.754095 |
|
| 5 | -3832.409025 |
|
| 6 | -3415.244227 |
|
| 7 | -3146.161065 |
|
| 8 | -2831.26839 |
|
| 9 | -2242.13685 |
|
| 10 | -1990.271919 |
|
| 11 | -1909.665453 |
|
| 12 | -1582.984687 |
|
| 13 | -907.938697 |
|
| 14 | -770.090351 |
|
| 15 | -710.516765 |
|
| 16 | -585.258716 |
|
| 17 | -555.0297 |
|
| 18 | -392.145592 |
|
| 19 | -192.531129 |
|
| 20 | -162.166918 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -6946.16733 |
|
-10338.909169 |
|
| 2 | -2058.961889 |
|
-1719.599428 |
|
| 3 | -1016.284134 |
|
-1646.290508 |
|
| 4 | -857.351907 |
|
-1283.088839 |
|
| 5 | -767.55783 |
|
-758.565123 |
|
| 6 | -602.133087 |
|
-374.331995 |
|
| 7 | -592.382408 |
|
-311.647136 |
|
| 8 | -450.911095 |
|
-239.086825 |
|
| 9 | -397.961499 |
|
-226.340904 |
|
| 10 | -337.310317 |
|
-204.948567 |
|
| 11 | -238.18326 |
|
-184.307007 |
|
| 12 | -213.68041 |
|
-178.686921 |
|
| 13 | -183.515053 |
|
-172.601175 |
|
| 14 | -157.138929 |
|
-169.861508 |
|
| 15 | -126.761381 |
|
-158.09939 |
|
| 16 | -121.377205 |
|
-113.376948 |
|
| 17 | -88.297155 |
|
-100.608755 |
|
| 18 | -81.753156 |
|
-29.136129 |
|
| 19 | -72.339353 |
|
-19.000448 |
|
| 20 | -64.481732 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -6496.264389 |
|
-9172.80969 |
|
| 2 | -5644.470235 |
|
-9151.539465 |
|
| 3 | -5114.645862 |
|
-8026.6975 |
|
| 4 | -1904.829643 |
|
-1646.293114 |
|
| 5 | -795.69855 |
|
-708.575302 |
|
| 6 | -471.907712 |
|
-450.313312 |
|
| 7 | -428.105488 |
|
-342.71742 |
|
| 8 | -323.876493 |
|
-245.032937 |
|
| 9 | -208.11183 |
|
-216.34386 |
|
| 10 | -177.975373 |
|
-183.883903 |
|
| 11 | -151.286337 |
|
-163.169412 |
|
| 12 | -118.160092 |
|
-143.08499 |
|
| 13 | -116.436504 |
|
-107.036944 |
|
| 14 | -106.350845 |
|
-79.845798 |
|
| 15 | -85.103831 |
|
||
| 16 | -65.667142 |
|
||
| 17 | -32.857372 |
|
||
| 18 | -29.062123 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 9e-74 |
|
| 2 | 2e-27 |
|
| 3 | 4e-24 |
|
| 4 | 2.8e-19 |
|
| 5 | 3.1e-16 |
|
| 6 | 2.7e-05 |
|
| 7 | 4.1e-07 |
|
| 8 | 0.00021 |
|
| 9 | 0.5 |
|
| 10 | 6.3e-06 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 1.4e-141 |
|
1e-240 |
|
| 2 | 2e-39 |
|
6.3e-51 |
|
| 3 | 8.4e-16 |
|
6.9e-47 |
|
| 4 | 1.5e-13 |
|
9.1e-41 |
|
| 5 | 4.3e-06 |
|
9.3e-06 |
|
| 6 | 0.0046 |
|
0.00038 |
|
| 7 | 0.0038 |
|
64.0 |
|
| 8 | 2.4 |
|
200000.0 |
|
| 9 | 45.0 |
|
600000.0 |
|
| 10 | 240.0 |
|
280000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 2.3e-195 |
|
1.5e-253 |
|
| 2 | 1.2e-139 |
|
3.4e-217 |
|
| 3 | 7.3e-61 |
|
2.5e-130 |
|
| 4 | 2.8e-17 |
|
8.6e-17 |
|
| 5 | 5.5e-14 |
|
6.4e-10 |
|
| 6 | 0.018 |
|
0.017 |
|
| 7 | 1.3 |
|
4100.0 |
|
| 8 | 5.1 |
|
12000000.0 |
|
| 9 | 170.0 |
|
22000000.0 |
|
| 10 | 210.0 |
|
110000000.0 |
|