DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1807 |
|
| 5 | 1248 |
|
| 6 | 479 |
|
| 7 | 317 |
|
| 8 | 164 |
|
| 9 | 77 |
|
| 10 | 19 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 4143 |
|
3201 |
|
| 2 | 963 |
|
290 |
|
| 3 | 530 |
|
93 |
|
| 4 | 339 |
|
19 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 4748 |
|
3392 |
|
| 2 | 640 |
|
474 |
|
| 3 | 621 |
|
134 |
|
| 4 | 188 |
|
14 |
|
| 5 | 46 |
|
||
| 6 | 10 |
|
||
| 7 | 1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -4432.353914 |
|
| 2 | -1129.48885 |
|
| 3 | -874.681872 |
|
| 4 | -606.722503 |
|
| 5 | -568.0369 |
|
| 6 | -546.547601 |
|
| 7 | -422.042822 |
|
| 8 | -395.70125 |
|
| 9 | -389.2769 |
|
| 10 | -388.059159 |
|
| 11 | -355.272083 |
|
| 12 | -258.226616 |
|
| 13 | -256.798266 |
|
| 14 | -256.292894 |
|
| 15 | -218.197763 |
|
| 16 | -212.851355 |
|
| 17 | -115.853743 |
|
| 18 | -93.790034 |
|
| 19 | -89.909064 |
|
| 20 | -71.634624 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -9072.409338 |
|
-9349.172469 |
|
| 2 | -1327.706276 |
|
-1020.51215 |
|
| 3 | -514.602758 |
|
-140.21704 |
|
| 4 | -207.480818 |
|
-123.99099 |
|
| 5 | -174.314874 |
|
-122.990197 |
|
| 6 | -160.008913 |
|
-82.149599 |
|
| 7 | -134.381141 |
|
-81.924978 |
|
| 8 | -129.512564 |
|
-73.283245 |
|
| 9 | -115.090479 |
|
-64.603972 |
|
| 10 | -110.347592 |
|
-62.700317 |
|
| 11 | -105.162931 |
|
-56.130874 |
|
| 12 | -86.483001 |
|
-56.130874 |
|
| 13 | -66.957942 |
|
-51.97876 |
|
| 14 | -59.435146 |
|
-41.139998 |
|
| 15 | -8.736661 |
|
-39.903103 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -8873.154628 |
|
-9140.273534 |
|
| 2 | -1763.004732 |
|
-1995.149309 |
|
| 3 | -627.332747 |
|
-193.363785 |
|
| 4 | -276.476692 |
|
-123.609741 |
|
| 5 | -259.63623 |
|
-104.703899 |
|
| 6 | -237.942045 |
|
-90.891747 |
|
| 7 | -184.611301 |
|
-86.364604 |
|
| 8 | -119.914425 |
|
-86.364604 |
|
| 9 | -101.00782 |
|
-77.435108 |
|
| 10 | -86.526761 |
|
-60.129648 |
|
| 11 | -77.697557 |
|
-43.698052 |
|
| 12 | -44.625923 |
|
-27.678552 |
|
| 13 | -34.405576 |
|
||
| 14 | -31.443548 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 6.5e-120 |
|
| 3 | 4.1e-42 |
|
| 4 | 9.6e-29 |
|
| 5 | 4.3e-14 |
|
| 6 | 6.4e-08 |
|
| 7 | 0.00087 |
|
| 8 | 0.16 |
|
| 9 | 0.42 |
|
| 10 | 1.2 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 3.1e-83 |
|
2.3e-118 |
|
| 3 | 290.0 |
|
7.8e-06 |
|
| 4 | 25000.0 |
|
0.02 |
|
| 5 | 89000.0 |
|
0.58 |
|
| 6 | 220000.0 |
|
75.0 |
|
| 7 | 280000.0 |
|
2000.0 |
|
| 8 | 390000.0 |
|
42000.0 |
|
| 9 | 800000.0 |
|
370000.0 |
|
| 10 | 1600000.0 |
|
530000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 3.6e-112 |
|
5.2e-246 |
|
| 3 | 0.00076 |
|
0.00047 |
|
| 4 | 2.4 |
|
0.44 |
|
| 5 | 180.0 |
|
160.0 |
|
| 6 | 23000.0 |
|
770.0 |
|
| 7 | 68000.0 |
|
1400.0 |
|
| 8 | 100000.0 |
|
9000.0 |
|
| 9 | 1800000.0 |
|
340000.0 |
|
| 10 | 1800000.0 |
|
1300000.0 |
|