DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1314 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1999 |
|
| 5 | 1928 |
|
| 6 | 1320 |
|
| 7 | 662 |
|
| 8 | 539 |
|
| 9 | 78 |
|
| 10 | 66 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 12206 |
|
11974 |
|
| 2 | 2776 |
|
2256 |
|
| 3 | 830 |
|
1258 |
|
| 4 | 306 |
|
||
| 5 | 43 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 11269 |
|
12094 |
|
| 2 | 2343 |
|
2519 |
|
| 3 | 1059 |
|
534 |
|
| 4 | 230 |
|
429 |
|
| 5 | 4 |
|
127 |
|
| 6 | 64 |
|
||
| 7 | 4 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -8119.584014 |
|
| 2 | -4712.995136 |
|
| 3 | -3927.495442 |
|
| 4 | -3867.897114 |
|
| 5 | -3540.849902 |
|
| 6 | -3509.810373 |
|
| 7 | -3347.269264 |
|
| 8 | -3137.07037 |
|
| 9 | -2828.896338 |
|
| 10 | -2796.657344 |
|
| 11 | -1891.154573 |
|
| 12 | -1780.876243 |
|
| 13 | -1529.680489 |
|
| 14 | -1481.216324 |
|
| 15 | -1477.490408 |
|
| 16 | -1252.51596 |
|
| 17 | -1243.740012 |
|
| 18 | -1201.734693 |
|
| 19 | -1198.303256 |
|
| 20 | -713.693888 |
|
| 21 | -472.729384 |
|
| 22 | -415.831578 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -13155.444422 |
|
-16631.807082 |
|
| 2 | -3354.935842 |
|
-5506.644945 |
|
| 3 | -919.222734 |
|
-1227.949279 |
|
| 4 | -874.695752 |
|
-871.950571 |
|
| 5 | -481.984705 |
|
-491.696729 |
|
| 6 | -457.583099 |
|
-438.204186 |
|
| 7 | -350.902232 |
|
-418.099207 |
|
| 8 | -334.983157 |
|
-357.491228 |
|
| 9 | -219.150022 |
|
-126.056227 |
|
| 10 | -218.82175 |
|
-112.93305 |
|
| 11 | -210.219818 |
|
-90.734819 |
|
| 12 | -176.465002 |
|
-16.134697 |
|
| 13 | -152.855958 |
|
||
| 14 | -152.855958 |
|
||
| 15 | -142.684621 |
|
||
| 16 | -121.662801 |
|
||
| 17 | -74.99812 |
|
||
| 18 | -61.288917 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -12277.701588 |
|
-19823.825097 |
|
| 2 | -4483.880925 |
|
-6988.50427 |
|
| 3 | -1568.084186 |
|
-2451.720981 |
|
| 4 | -703.458734 |
|
-1247.96698 |
|
| 5 | -676.273043 |
|
-550.514286 |
|
| 6 | -567.881314 |
|
-475.905743 |
|
| 7 | -468.445038 |
|
-436.358993 |
|
| 8 | -465.352945 |
|
-259.360087 |
|
| 9 | -396.96147 |
|
-220.264838 |
|
| 10 | -323.284811 |
|
-134.368845 |
|
| 11 | -303.167855 |
|
-125.180508 |
|
| 12 | -278.322245 |
|
-86.92743 |
|
| 13 | -181.676239 |
|
||
| 14 | -166.467041 |
|
||
| 15 | -140.304197 |
|
||
| 16 | -125.615454 |
|
||
| 17 | -81.915139 |
|
||
| 18 | -58.517482 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 3.8e-115 |
|
| 2 | 4.3e-53 |
|
| 3 | 3.4e-45 |
|
| 4 | 1.8e-39 |
|
| 5 | 3.6e-19 |
|
| 6 | 4.5e-16 |
|
| 7 | 8.4e-13 |
|
| 8 | 6.5e-11 |
|
| 9 | 7.2e-08 |
|
| 10 | 1.1e-06 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.2e-142 |
|
1.5e-170 |
|
| 3 | 1.3e-16 |
|
2.3e-20 |
|
| 4 | 2.7e-10 |
|
4.3 |
|
| 5 | 0.013 |
|
4.4 |
|
| 6 | 0.094 |
|
47.0 |
|
| 7 | 26.0 |
|
9500.0 |
|
| 8 | 11.0 |
|
120000.0 |
|
| 9 | 480.0 |
|
180000.0 |
|
| 10 | 41000.0 |
|
280000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 2.3e-315 |
|
0.0 |
|
| 2 | 2e-124 |
|
4.1e-168 |
|
| 3 | 1.2e-15 |
|
1.4e-75 |
|
| 4 | 1.5e-10 |
|
7.2e-20 |
|
| 5 | 0.0027 |
|
1.3e-05 |
|
| 6 | 0.0044 |
|
140.0 |
|
| 7 | 2.2 |
|
3100.0 |
|
| 8 | 660.0 |
|
66000.0 |
|
| 9 | 18000.0 |
|
570000.0 |
|
| 10 | 100000.0 |
|
910000.0 |
|