DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1543 |
|
| 2 | 2000 |
|
| 3 | 1998 |
|
| 4 | 1839 |
|
| 5 | 1038 |
|
| 6 | 489 |
|
| 7 | 271 |
|
| 8 | 207 |
|
| 9 | 150 |
|
| 10 | 139 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 7673 |
|
6069 |
|
| 2 | 3441 |
|
2210 |
|
| 3 | 494 |
|
87 |
|
| 4 | 161 |
|
61 |
|
| 5 | 5 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 7359 |
|
5623 |
|
| 2 | 3585 |
|
1622 |
|
| 3 | 501 |
|
369 |
|
| 4 | 862 |
|
156 |
|
| 5 | 96 |
|
||
| 6 | 7 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -4727.755725 |
|
| 2 | -1687.525596 |
|
| 3 | -1240.836463 |
|
| 4 | -1030.421905 |
|
| 5 | -1018.864727 |
|
| 6 | -942.067266 |
|
| 7 | -888.652618 |
|
| 8 | -885.887935 |
|
| 9 | -778.122437 |
|
| 10 | -762.344094 |
|
| 11 | -658.259198 |
|
| 12 | -613.353962 |
|
| 13 | -475.601382 |
|
| 14 | -454.202731 |
|
| 15 | -450.671199 |
|
| 16 | -404.821986 |
|
| 17 | -393.291763 |
|
| 18 | -230.061354 |
|
| 19 | -92.490713 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -12046.988673 |
|
-13786.674383 |
|
| 2 | -1214.866111 |
|
-1329.641395 |
|
| 3 | -793.500349 |
|
-433.174762 |
|
| 4 | -672.502098 |
|
-385.974818 |
|
| 5 | -561.010065 |
|
-350.483906 |
|
| 6 | -438.211288 |
|
-270.951855 |
|
| 7 | -333.682008 |
|
-263.468642 |
|
| 8 | -315.203586 |
|
-196.092673 |
|
| 9 | -207.899578 |
|
-150.148245 |
|
| 10 | -176.615983 |
|
-148.757622 |
|
| 11 | -171.676368 |
|
||
| 12 | -126.437322 |
|
||
| 13 | -74.90378 |
|
||
| 14 | -51.480017 |
|
||
| 15 | -41.154876 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -12739.992469 |
|
-15150.881471 |
|
| 2 | -908.111396 |
|
-685.280624 |
|
| 3 | -735.103603 |
|
-606.631819 |
|
| 4 | -422.181959 |
|
-188.312554 |
|
| 5 | -414.852501 |
|
-163.859319 |
|
| 6 | -338.994046 |
|
-127.724405 |
|
| 7 | -331.177937 |
|
-103.948171 |
|
| 8 | -311.038731 |
|
-103.315428 |
|
| 9 | -287.635221 |
|
-100.117654 |
|
| 10 | -229.196114 |
|
-60.601253 |
|
| 11 | -170.5874 |
|
-44.066902 |
|
| 12 | -150.466215 |
|
-18.296272 |
|
| 13 | -143.148177 |
|
||
| 14 | -142.415203 |
|
||
| 15 | -116.091776 |
|
||
| 16 | -111.316391 |
|
||
| 17 | -52.72324 |
|
||
| 18 | -32.816608 |
|
||
| 19 | -23.97229 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 5.9e-129 |
|
| 2 | 6.7e-30 |
|
| 3 | 3.9e-21 |
|
| 4 | 6.1e-13 |
|
| 5 | 1.1e-12 |
|
| 6 | 3.4e-08 |
|
| 7 | 1.3e-05 |
|
| 8 | 15.0 |
|
| 9 | 2.5 |
|
| 10 | 18.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 4.1e-32 |
|
1.7e-62 |
|
| 3 | 7.6e-15 |
|
24.0 |
|
| 4 | 1.3e-09 |
|
86.0 |
|
| 5 | 1.2e-07 |
|
150.0 |
|
| 6 | 3.3e-05 |
|
220.0 |
|
| 7 | 0.15 |
|
38000.0 |
|
| 8 | 1200.0 |
|
390000.0 |
|
| 9 | 37000.0 |
|
600000.0 |
|
| 10 | 290000.0 |
|
990000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 8.6e-21 |
|
8e-09 |
|
| 3 | 1.8e-11 |
|
0.00014 |
|
| 4 | 0.00042 |
|
0.21 |
|
| 5 | 0.088 |
|
31.0 |
|
| 6 | 56000.0 |
|
14000.0 |
|
| 7 | 72000.0 |
|
550000.0 |
|
| 8 | 130000.0 |
|
640000.0 |
|
| 9 | 330000.0 |
|
1300000.0 |
|
| 10 | 470000.0 |
|
1300000.0 |
|