DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1997 |
|
| 2 | 2000 |
|
| 3 | 1998 |
|
| 4 | 1712 |
|
| 5 | 934 |
|
| 6 | 415 |
|
| 7 | 192 |
|
| 8 | 159 |
|
| 9 | 63 |
|
| 10 | 63 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 11102 |
|
8077 |
|
| 2 | 1582 |
|
2858 |
|
| 3 | 597 |
|
189 |
|
| 4 | 41 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 9907 |
|
5635 |
|
| 2 | 4670 |
|
2525 |
|
| 3 | 33 |
|
800 |
|
| 4 | 5 |
|
231 |
|
| 5 | 51 |
|
||
| 6 | 16 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -2506.827597 |
|
| 2 | -2073.259008 |
|
| 3 | -1717.958485 |
|
| 4 | -1598.9711 |
|
| 5 | -1462.091416 |
|
| 6 | -1255.879349 |
|
| 7 | -1171.646217 |
|
| 8 | -1129.993354 |
|
| 9 | -942.683541 |
|
| 10 | -938.982683 |
|
| 11 | -869.258945 |
|
| 12 | -785.656157 |
|
| 13 | -736.990426 |
|
| 14 | -678.447248 |
|
| 15 | -597.530083 |
|
| 16 | -573.895153 |
|
| 17 | -311.056492 |
|
| 18 | -232.982635 |
|
| 19 | -175.933827 |
|
| 20 | -130.666474 |
|
| 21 | -106.185461 |
|
| 22 | -51.912349 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -9533.348254 |
|
-9764.467368 |
|
| 2 | -1779.172526 |
|
-1859.267136 |
|
| 3 | -1225.539903 |
|
-1334.401975 |
|
| 4 | -821.71859 |
|
-962.822217 |
|
| 5 | -771.7383 |
|
-642.805945 |
|
| 6 | -684.111862 |
|
-328.463578 |
|
| 7 | -655.291735 |
|
-275.369878 |
|
| 8 | -486.970828 |
|
-259.39964 |
|
| 9 | -382.834675 |
|
-164.188356 |
|
| 10 | -343.724612 |
|
-105.145037 |
|
| 11 | -336.754494 |
|
-85.898285 |
|
| 12 | -319.701086 |
|
-67.117456 |
|
| 13 | -263.844137 |
|
-49.870912 |
|
| 14 | -228.695449 |
|
-36.225715 |
|
| 15 | -228.695449 |
|
||
| 16 | -215.037171 |
|
||
| 17 | -207.868309 |
|
||
| 18 | -173.02801 |
|
||
| 19 | -167.467817 |
|
||
| 20 | -106.510547 |
|
||
| 21 | -36.193041 |
|
||
| 22 | -22.274561 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -8894.666971 |
|
-10338.355895 |
|
| 2 | -3067.895493 |
|
-3534.123961 |
|
| 3 | -1383.557213 |
|
-626.466309 |
|
| 4 | -866.368198 |
|
-581.507186 |
|
| 5 | -859.680208 |
|
-487.73266 |
|
| 6 | -795.238658 |
|
-369.927393 |
|
| 7 | -762.825934 |
|
-219.23709 |
|
| 8 | -754.175896 |
|
-94.15917 |
|
| 9 | -694.355519 |
|
-89.461858 |
|
| 10 | -636.787719 |
|
-49.647916 |
|
| 11 | -587.131917 |
|
-32.346825 |
|
| 12 | -525.865668 |
|
||
| 13 | -501.626333 |
|
||
| 14 | -448.2773 |
|
||
| 15 | -441.750488 |
|
||
| 16 | -440.627199 |
|
||
| 17 | -406.634102 |
|
||
| 18 | -401.344522 |
|
||
| 19 | -297.98123 |
|
||
| 20 | -212.352487 |
|
||
| 21 | -200.150618 |
|
||
| 22 | -121.509174 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 4e-78 |
|
| 2 | 6.7e-56 |
|
| 3 | 2.6e-33 |
|
| 4 | 7e-13 |
|
| 5 | 6.6e-15 |
|
| 6 | 6.2e-13 |
|
| 7 | 2.4e-09 |
|
| 8 | 1.5e-07 |
|
| 9 | 4.8e-08 |
|
| 10 | 1300.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 3.6e-232 |
|
0.0 |
|
| 2 | 6.9e-101 |
|
9e-40 |
|
| 3 | 2.7e-59 |
|
2.1e-16 |
|
| 4 | 6.5e-39 |
|
0.0049 |
|
| 5 | 5.4e-36 |
|
26.0 |
|
| 6 | 1.4e-16 |
|
58000.0 |
|
| 7 | 2e-13 |
|
81000.0 |
|
| 8 | 1.6e-09 |
|
440000.0 |
|
| 9 | 0.00068 |
|
520000.0 |
|
| 10 | 0.013 |
|
550000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 4.9e-209 |
|
0.0 |
|
| 2 | 1.4e-142 |
|
9.4e-131 |
|
| 3 | 4.9e-72 |
|
1.5e-09 |
|
| 4 | 3e-54 |
|
0.015 |
|
| 5 | 7e-43 |
|
14000.0 |
|
| 6 | 9.2e-38 |
|
160000.0 |
|
| 7 | 8.7e-37 |
|
220000.0 |
|
| 8 | 4.1e-12 |
|
240000.0 |
|
| 9 | 1.7e-08 |
|
280000.0 |
|
| 10 | 3.7e-08 |
|
460000.0 |
|