DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1285 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1999 |
|
| 5 | 1904 |
|
| 6 | 1099 |
|
| 7 | 425 |
|
| 8 | 219 |
|
| 9 | 177 |
|
| 10 | 111 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 12506 |
|
13565 |
|
| 2 | 1873 |
|
2062 |
|
| 3 | 1200 |
|
831 |
|
| 4 | 254 |
|
326 |
|
| 5 | 66 |
|
||
| 6 | 1 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 12561 |
|
13048 |
|
| 2 | 2573 |
|
1861 |
|
| 3 | 320 |
|
946 |
|
| 4 | 33 |
|
420 |
|
| 5 | 8 |
|
116 |
|
| 6 | 2 |
|
52 |
|
| 7 | 1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -18415.064352 |
|
| 2 | -6400.051081 |
|
| 3 | -6143.68663 |
|
| 4 | -5858.202826 |
|
| 5 | -5783.888159 |
|
| 6 | -5569.71824 |
|
| 7 | -4760.899497 |
|
| 8 | -4119.241685 |
|
| 9 | -4043.188898 |
|
| 10 | -3116.153867 |
|
| 11 | -2771.897062 |
|
| 12 | -2765.491423 |
|
| 13 | -1360.682858 |
|
| 14 | -1295.576277 |
|
| 15 | -1252.316565 |
|
| 16 | -1221.729465 |
|
| 17 | -815.029826 |
|
| 18 | -775.960905 |
|
| 19 | -581.634255 |
|
| 20 | -315.056537 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -15597.571738 |
|
-23900.32802 |
|
| 2 | -2968.138838 |
|
-5785.768674 |
|
| 3 | -604.130508 |
|
-708.245461 |
|
| 4 | -461.455262 |
|
-512.160943 |
|
| 5 | -407.119469 |
|
-428.558395 |
|
| 6 | -290.441098 |
|
-273.851623 |
|
| 7 | -229.904413 |
|
-242.850127 |
|
| 8 | -226.872215 |
|
-184.816597 |
|
| 9 | -203.34822 |
|
-179.684728 |
|
| 10 | -151.723508 |
|
-149.397092 |
|
| 11 | -149.340341 |
|
-110.545513 |
|
| 12 | -148.711296 |
|
-96.508968 |
|
| 13 | -146.715708 |
|
-82.81294 |
|
| 14 | -86.160858 |
|
-65.158276 |
|
| 15 | -60.38801 |
|
-60.866849 |
|
| 16 | -16.285525 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -13246.06182 |
|
-24660.501592 |
|
| 2 | -4002.220363 |
|
-5317.366376 |
|
| 3 | -1980.528729 |
|
-3624.274525 |
|
| 4 | -809.863763 |
|
-818.859292 |
|
| 5 | -596.823169 |
|
-532.792845 |
|
| 6 | -375.176524 |
|
-325.03727 |
|
| 7 | -324.27497 |
|
-302.621883 |
|
| 8 | -266.239653 |
|
-198.698907 |
|
| 9 | -242.109681 |
|
-178.179166 |
|
| 10 | -220.820553 |
|
-168.05551 |
|
| 11 | -208.03021 |
|
-104.853826 |
|
| 12 | -204.192983 |
|
-89.692027 |
|
| 13 | -114.987023 |
|
-60.241634 |
|
| 14 | -106.903694 |
|
-56.039445 |
|
| 15 | -87.093026 |
|
||
| 16 | -74.57247 |
|
||
| 17 | -69.297266 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 7.4e-186 |
|
| 2 | 1.1e-49 |
|
| 3 | 1.1e-30 |
|
| 4 | 8.7e-40 |
|
| 5 | 1e-29 |
|
| 6 | 4.5e-10 |
|
| 7 | 7.5e-07 |
|
| 8 | 2.4e-05 |
|
| 9 | 0.00093 |
|
| 10 | 6.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2.9e-39 |
|
5.2e-93 |
|
| 3 | 2.8e-33 |
|
5e-16 |
|
| 4 | 26.0 |
|
27000.0 |
|
| 5 | 55.0 |
|
470000.0 |
|
| 6 | 3100.0 |
|
1500000.0 |
|
| 7 | 42000.0 |
|
2000000.0 |
|
| 8 | 180000.0 |
|
2300000.0 |
|
| 9 | 230000.0 |
|
2300000.0 |
|
| 10 | 150000.0 |
|
2300000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 9.3e-92 |
|
1.2e-133 |
|
| 3 | 2.6e-42 |
|
1e-50 |
|
| 4 | 2.9e-25 |
|
12.0 |
|
| 5 | 4.3e-09 |
|
300000.0 |
|
| 6 | 0.037 |
|
580000.0 |
|
| 7 | 0.1 |
|
1000000.0 |
|
| 8 | 200.0 |
|
1900000.0 |
|
| 9 | 1200.0 |
|
2100000.0 |
|
| 10 | 99000.0 |
|
2200000.0 |
|