DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1600 |
|
| 2 | 1999 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1956 |
|
| 6 | 1113 |
|
| 7 | 454 |
|
| 8 | 211 |
|
| 9 | 89 |
|
| 10 | 39 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 14472 |
|
14372 |
|
| 2 | 846 |
|
666 |
|
| 3 | 206 |
|
179 |
|
| 4 | 164 |
|
81 |
|
| 5 | 7 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 13183 |
|
10358 |
|
| 2 | 720 |
|
918 |
|
| 3 | 342 |
|
53 |
|
| 4 | 15 |
|
34 |
|
| 5 | 4 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -16302.369038 |
|
| 2 | -1401.070196 |
|
| 3 | -1385.676098 |
|
| 4 | -1247.748923 |
|
| 5 | -1044.455021 |
|
| 6 | -912.774005 |
|
| 7 | -908.135213 |
|
| 8 | -896.944474 |
|
| 9 | -860.070296 |
|
| 10 | -520.464001 |
|
| 11 | -514.103155 |
|
| 12 | -484.71292 |
|
| 13 | -445.030172 |
|
| 14 | -381.486955 |
|
| 15 | -337.950192 |
|
| 16 | -282.847281 |
|
| 17 | -269.74602 |
|
| 18 | -46.573028 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -22347.781865 |
|
-23836.66292 |
|
| 2 | -10517.177045 |
|
-12283.5693 |
|
| 3 | -6667.070759 |
|
-2453.055239 |
|
| 4 | -1997.558646 |
|
-2193.43624 |
|
| 5 | -1591.521239 |
|
-1085.282716 |
|
| 6 | -621.819875 |
|
-814.495556 |
|
| 7 | -365.171136 |
|
-191.448175 |
|
| 8 | -200.40479 |
|
-122.598732 |
|
| 9 | -134.364775 |
|
-92.462421 |
|
| 10 | -122.314064 |
|
-47.462267 |
|
| 11 | -96.8371 |
|
||
| 12 | -92.814437 |
|
||
| 13 | -30.222897 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -23937.729974 |
|
-24070.012392 |
|
| 2 | -9699.908238 |
|
-17217.018008 |
|
| 3 | -1825.276057 |
|
-1696.04459 |
|
| 4 | -1461.316975 |
|
-1577.446754 |
|
| 5 | -1116.410396 |
|
-1421.84354 |
|
| 6 | -227.376471 |
|
-448.061873 |
|
| 7 | -225.031908 |
|
-226.676243 |
|
| 8 | -156.021317 |
|
-128.751554 |
|
| 9 | -131.667437 |
|
-103.466373 |
|
| 10 | -122.123752 |
|
-99.796942 |
|
| 11 | -89.747959 |
|
-72.363729 |
|
| 12 | -18.398566 |
|
-39.692624 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 1.5e-55 |
|
| 3 | 3.8e-42 |
|
| 4 | 2.9e-38 |
|
| 5 | 1.1e-24 |
|
| 6 | 5.7e-34 |
|
| 7 | 5.8e-20 |
|
| 8 | 2e-18 |
|
| 9 | 9.8e-10 |
|
| 10 | 5.6e-09 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 4.7e-20 |
|
5.3e-36 |
|
| 3 | 3.4e-09 |
|
2.4e-08 |
|
| 4 | 8.5e-21 |
|
1.4e-05 |
|
| 5 | 9.9e-08 |
|
0.00045 |
|
| 6 | 0.027 |
|
0.011 |
|
| 7 | 0.42 |
|
0.00056 |
|
| 8 | 0.66 |
|
750.0 |
|
| 9 | 2.0 |
|
800.0 |
|
| 10 | 14.0 |
|
32000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 3.8e-41 |
|
4.2e-45 |
|
| 3 | 1.1e-25 |
|
0.065 |
|
| 4 | 2.6e-25 |
|
540.0 |
|
| 5 | 7.3e-10 |
|
1000.0 |
|
| 6 | 2.1e-06 |
|
150000.0 |
|
| 7 | 0.013 |
|
720000.0 |
|
| 8 | 4700.0 |
|
900000.0 |
|
| 9 | 170000.0 |
|
950000.0 |
|
| 10 | 220000.0 |
|
1500000.0 |
|