DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1328 |
|
| 2 | 1999 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1950 |
|
| 6 | 1288 |
|
| 7 | 687 |
|
| 8 | 119 |
|
| 9 | 67 |
|
| 10 | 3 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 16750 |
|
16594 |
|
| 2 | 1092 |
|
465 |
|
| 3 | 1 |
|
131 |
|
| 4 | 97 |
|
||
| 5 | 18 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 16572 |
|
16374 |
|
| 2 | 1169 |
|
884 |
|
| 3 | 100 |
|
||
| 4 | 85 |
|
||
| 5 | 8 |
|
||
| 6 | 1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -63152.142009 |
|
| 2 | -7246.315955 |
|
| 3 | -6870.807423 |
|
| 4 | -6727.622321 |
|
| 5 | -6378.402541 |
|
| 6 | -5824.484355 |
|
| 7 | -4697.384225 |
|
| 8 | -3200.387686 |
|
| 9 | -3193.484849 |
|
| 10 | -3006.013196 |
|
| 11 | -2485.117906 |
|
| 12 | -2464.153244 |
|
| 13 | -2390.145837 |
|
| 14 | -2004.5327 |
|
| 15 | -1417.032167 |
|
| 16 | -1077.858075 |
|
| 17 | -660.939969 |
|
| 18 | -598.589324 |
|
| 19 | -562.182806 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -19056.889765 |
|
-21540.413316 |
|
| 2 | -7068.256632 |
|
-4713.417156 |
|
| 3 | -2585.779909 |
|
-3978.728947 |
|
| 4 | -1242.932828 |
|
-3465.559253 |
|
| 5 | -550.185502 |
|
-3127.172613 |
|
| 6 | -478.589855 |
|
-2955.420162 |
|
| 7 | -272.02029 |
|
-1362.975777 |
|
| 8 | -218.724514 |
|
-832.911054 |
|
| 9 | -201.233624 |
|
-650.776954 |
|
| 10 | -147.500347 |
|
-337.766118 |
|
| 11 | -134.918977 |
|
-197.707613 |
|
| 12 | -104.398899 |
|
-194.911001 |
|
| 13 | -33.138697 |
|
-137.54733 |
|
| 14 | -24.613622 |
|
-85.997997 |
|
| 15 | -48.929959 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -22727.932015 |
|
-22104.145939 |
|
| 2 | -3023.173003 |
|
-5184.839348 |
|
| 3 | -2416.676138 |
|
-4344.749286 |
|
| 4 | -2066.44454 |
|
-3927.158747 |
|
| 5 | -1371.725 |
|
-1909.877513 |
|
| 6 | -388.726571 |
|
-1856.542573 |
|
| 7 | -255.653673 |
|
-1565.404553 |
|
| 8 | -229.062224 |
|
-410.744751 |
|
| 9 | -219.556723 |
|
-347.57833 |
|
| 10 | -187.511383 |
|
-336.829377 |
|
| 11 | -139.099872 |
|
-330.703783 |
|
| 12 | -108.965384 |
|
-197.281393 |
|
| 13 | -27.664804 |
|
-151.908079 |
|
| 14 | -122.807159 |
|
||
| 15 | -96.841078 |
|
||
| 16 | -62.207803 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 5.4e-315 |
|
| 3 | 8.8e-30 |
|
| 4 | 8.8e-30 |
|
| 5 | 8.8e-30 |
|
| 6 | 8.8e-30 |
|
| 7 | 8.8e-30 |
|
| 8 | 8.8e-30 |
|
| 9 | 8.8e-30 |
|
| 10 | 8.8e-30 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.2e-14 |
|
2.8e-36 |
|
| 3 | 8.8e-13 |
|
0.02 |
|
| 4 | 0.027 |
|
7.9e-08 |
|
| 5 | 0.46 |
|
29.0 |
|
| 6 | 34.0 |
|
95.0 |
|
| 7 | 150.0 |
|
3600.0 |
|
| 8 | 36000.0 |
|
34000.0 |
|
| 9 | 1400000.0 |
|
120000.0 |
|
| 10 | 2600000.0 |
|
180000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 4.3e-12 |
|
9.6e-52 |
|
| 3 | 2e-06 |
|
1.3e-07 |
|
| 4 | 10.0 |
|
9.6e-06 |
|
| 5 | 24.0 |
|
0.18 |
|
| 6 | 29.0 |
|
0.81 |
|
| 7 | 1400.0 |
|
39000.0 |
|
| 8 | 2000.0 |
|
670000.0 |
|
| 9 | 110.0 |
|
1400000.0 |
|
| 10 | 110000.0 |
|
1400000.0 |
|