DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1522 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1994 |
|
| 5 | 1680 |
|
| 6 | 1139 |
|
| 7 | 626 |
|
| 8 | 323 |
|
| 9 | 220 |
|
| 10 | 153 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 13725 |
|
16845 |
|
| 2 | 284 |
|
457 |
|
| 3 | 678 |
|
186 |
|
| 4 | 79 |
|
||
| 5 | 34 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 16355 |
|
16274 |
|
| 2 | 296 |
|
627 |
|
| 3 | 335 |
|
121 |
|
| 4 | 5 |
|
2 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -29205.210024 |
|
| 2 | -2684.433799 |
|
| 3 | -2654.257799 |
|
| 4 | -2351.44842 |
|
| 5 | -2271.323913 |
|
| 6 | -2130.891294 |
|
| 7 | -1980.966329 |
|
| 8 | -1647.031091 |
|
| 9 | -1266.757681 |
|
| 10 | -1061.572197 |
|
| 11 | -1057.52418 |
|
| 12 | -977.826252 |
|
| 13 | -840.196617 |
|
| 14 | -757.597562 |
|
| 15 | -350.359274 |
|
| 16 | -250.717675 |
|
| 17 | -115.395515 |
|
| 18 | -104.669211 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -16348.761582 |
|
-27532.418578 |
|
| 2 | -2726.429481 |
|
-3531.091064 |
|
| 3 | -2308.583411 |
|
-2324.313728 |
|
| 4 | -1858.320639 |
|
-1852.386578 |
|
| 5 | -1823.11542 |
|
-536.51462 |
|
| 6 | -1489.631714 |
|
-289.708469 |
|
| 7 | -1225.382004 |
|
-257.688078 |
|
| 8 | -1165.372092 |
|
-186.861155 |
|
| 9 | -1158.728483 |
|
-182.739633 |
|
| 10 | -1106.660548 |
|
-138.511708 |
|
| 11 | -1105.758642 |
|
-113.226533 |
|
| 12 | -1085.97864 |
|
-100.001723 |
|
| 13 | -1053.116167 |
|
-96.720557 |
|
| 14 | -770.113108 |
|
-94.672418 |
|
| 15 | -436.109362 |
|
-56.466047 |
|
| 16 | -424.358748 |
|
||
| 17 | -101.700757 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -23100.633291 |
|
-31999.774015 |
|
| 2 | -2888.700934 |
|
-2217.34557 |
|
| 3 | -851.544206 |
|
-1879.400924 |
|
| 4 | -841.497899 |
|
-1619.577232 |
|
| 5 | -539.302504 |
|
-634.262527 |
|
| 6 | -454.186337 |
|
-456.703867 |
|
| 7 | -370.523218 |
|
-404.787334 |
|
| 8 | -309.112032 |
|
-253.332361 |
|
| 9 | -276.346141 |
|
-242.547703 |
|
| 10 | -276.346141 |
|
-195.896808 |
|
| 11 | -191.837289 |
|
-126.615566 |
|
| 12 | -179.949768 |
|
-112.463252 |
|
| 13 | -166.662804 |
|
-98.606745 |
|
| 14 | -125.694308 |
|
-88.086243 |
|
| 15 | -122.167213 |
|
||
| 16 | -31.796481 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 5.2e-119 |
|
| 3 | 7.4e-34 |
|
| 4 | 3.5e-27 |
|
| 5 | 1e-20 |
|
| 6 | 1.6e-18 |
|
| 7 | 1.2e-13 |
|
| 8 | 0.00039 |
|
| 9 | 0.064 |
|
| 10 | 0.076 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 8.3e-123 |
|
9.5e-116 |
|
| 3 | 1.7e-66 |
|
2.6e-68 |
|
| 4 | 4.7e-60 |
|
8.9e-05 |
|
| 5 | 1.6e-32 |
|
0.014 |
|
| 6 | 2.8e-32 |
|
15.0 |
|
| 7 | 1.9e-22 |
|
6400.0 |
|
| 8 | 1.6e-15 |
|
11000.0 |
|
| 9 | 3.7e-13 |
|
14000.0 |
|
| 10 | 2.4e-07 |
|
2700.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 4.5e-57 |
|
2.7e-96 |
|
| 3 | 3.1e-51 |
|
2.9 |
|
| 4 | 5.5e-09 |
|
480.0 |
|
| 5 | 0.19 |
|
3900.0 |
|
| 6 | 0.26 |
|
4100.0 |
|
| 7 | 1.5 |
|
74000.0 |
|
| 8 | 390.0 |
|
290000.0 |
|
| 9 | 6200.0 |
|
1900000.0 |
|
| 10 | 150000.0 |
|
2100000.0 |
|