DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1445 |
|
| 2 | 1997 |
|
| 3 | 2000 |
|
| 4 | 1997 |
|
| 5 | 1926 |
|
| 6 | 1092 |
|
| 7 | 635 |
|
| 8 | 293 |
|
| 9 | 131 |
|
| 10 | 43 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 15294 |
|
16326 |
|
| 2 | 1639 |
|
364 |
|
| 3 | 59 |
|
77 |
|
| 4 | 88 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 15824 |
|
16411 |
|
| 2 | 1295 |
|
638 |
|
| 3 | 65 |
|
||
| 4 | 9 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -44178.882737 |
|
| 2 | -6407.262417 |
|
| 3 | -6305.112128 |
|
| 4 | -5342.12795 |
|
| 5 | -4241.496721 |
|
| 6 | -3436.004115 |
|
| 7 | -2349.833067 |
|
| 8 | -2158.943472 |
|
| 9 | -1946.296803 |
|
| 10 | -1666.867323 |
|
| 11 | -1381.814375 |
|
| 12 | -1142.499773 |
|
| 13 | -466.982286 |
|
| 14 | -342.78158 |
|
| 15 | -178.27698 |
|
| 16 | -108.793889 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -16916.90938 |
|
-19402.071429 |
|
| 2 | -6129.986492 |
|
-5296.079776 |
|
| 3 | -4773.911505 |
|
-816.517438 |
|
| 4 | -1787.821141 |
|
-789.302171 |
|
| 5 | -1145.337859 |
|
-267.334884 |
|
| 6 | -1092.4533 |
|
-245.907199 |
|
| 7 | -903.625136 |
|
-229.122402 |
|
| 8 | -849.010872 |
|
-192.685011 |
|
| 9 | -783.098085 |
|
-162.290105 |
|
| 10 | -719.916161 |
|
-72.775645 |
|
| 11 | -701.243367 |
|
-38.193051 |
|
| 12 | -520.365848 |
|
||
| 13 | -518.498878 |
|
||
| 14 | -303.386847 |
|
||
| 15 | -294.528424 |
|
||
| 16 | -240.434349 |
|
||
| 17 | -20.517145 |
|
||
| 18 | -17.599526 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -17782.728648 |
|
-18372.854221 |
|
| 2 | -3406.457866 |
|
-3143.741964 |
|
| 3 | -3107.951685 |
|
-794.789619 |
|
| 4 | -1269.820715 |
|
-220.801506 |
|
| 5 | -1103.541209 |
|
-197.794451 |
|
| 6 | -990.888383 |
|
-134.627019 |
|
| 7 | -475.991345 |
|
-118.397191 |
|
| 8 | -446.72805 |
|
-93.141857 |
|
| 9 | -423.718007 |
|
-91.989639 |
|
| 10 | -371.95404 |
|
-68.117722 |
|
| 11 | -253.845072 |
|
-40.009383 |
|
| 12 | -253.845072 |
|
||
| 13 | -225.315468 |
|
||
| 14 | -225.315468 |
|
||
| 15 | -187.678461 |
|
||
| 16 | -132.87633 |
|
||
| 17 | -132.87633 |
|
||
| 18 | -128.053934 |
|
||
| 19 | -109.072712 |
|
||
| 20 | -61.033618 |
|
||
| 21 | -39.634429 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 6.4e-29 |
|
| 3 | 2.2e-23 |
|
| 4 | 7.2e-20 |
|
| 5 | 5.6e-11 |
|
| 6 | 2.4e-10 |
|
| 7 | 2.5e-06 |
|
| 8 | 0.00055 |
|
| 9 | 0.0046 |
|
| 10 | 1200.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 6e-48 |
|
2.2e-16 |
|
| 3 | 3.6e-41 |
|
2.4e-06 |
|
| 4 | 2.1e-33 |
|
1200.0 |
|
| 5 | 4.4e-12 |
|
510000.0 |
|
| 6 | 7.4e-10 |
|
830000.0 |
|
| 7 | 6.6e-07 |
|
1000000.0 |
|
| 8 | 8.6e-06 |
|
1000000.0 |
|
| 9 | 0.00077 |
|
1100000.0 |
|
| 10 | 0.075 |
|
1100000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.5e-53 |
|
3.1e-48 |
|
| 3 | 2.4e-23 |
|
16000.0 |
|
| 4 | 2.4e-23 |
|
1900000.0 |
|
| 5 | 2.4e-23 |
|
2000000.0 |
|
| 6 | 2.4e-23 |
|
2200000.0 |
|
| 7 | 2.4e-23 |
|
2300000.0 |
|
| 8 | 2.4e-23 |
|
2300000.0 |
|
| 9 | 2.4e-23 |
|
2600000.0 |
|
| 10 | 2.4e-23 |
|
3000000.0 |
|