DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1549 |
|
| 2 | 2000 |
|
| 3 | 1999 |
|
| 4 | 1984 |
|
| 5 | 1527 |
|
| 6 | 756 |
|
| 7 | 370 |
|
| 8 | 199 |
|
| 9 | 143 |
|
| 10 | 87 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 15533 |
|
16926 |
|
| 2 | 625 |
|
419 |
|
| 3 | 247 |
|
148 |
|
| 4 | 12 |
|
84 |
|
| 5 | 14 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 16229 |
|
15771 |
|
| 2 | 901 |
|
1057 |
|
| 3 | 139 |
|
||
| 4 | 54 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -80132.076028 |
|
| 2 | -26361.248712 |
|
| 3 | -10847.951494 |
|
| 4 | -6724.71928 |
|
| 5 | -6400.273306 |
|
| 6 | -4333.564868 |
|
| 7 | -4098.861041 |
|
| 8 | -3590.81408 |
|
| 9 | -3048.629247 |
|
| 10 | -3003.433234 |
|
| 11 | -2610.211859 |
|
| 12 | -2520.18595 |
|
| 13 | -2460.359196 |
|
| 14 | -877.765504 |
|
| 15 | -532.202319 |
|
| 16 | -476.679731 |
|
| 17 | -438.399004 |
|
| 18 | -413.220903 |
|
| 19 | -335.480586 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -19436.263886 |
|
-25262.063874 |
|
| 2 | -2260.057156 |
|
-5079.56589 |
|
| 3 | -2195.144531 |
|
-4356.702667 |
|
| 4 | -2074.168149 |
|
-435.471489 |
|
| 5 | -1334.479075 |
|
-394.383085 |
|
| 6 | -1081.06818 |
|
-321.688876 |
|
| 7 | -1057.129916 |
|
-283.149618 |
|
| 8 | -1054.197592 |
|
-254.267986 |
|
| 9 | -808.856935 |
|
-168.704928 |
|
| 10 | -789.869145 |
|
-151.374533 |
|
| 11 | -739.53698 |
|
-139.406572 |
|
| 12 | -714.541365 |
|
-89.345384 |
|
| 13 | -591.40804 |
|
-28.311343 |
|
| 14 | -501.300765 |
|
||
| 15 | -473.812446 |
|
||
| 16 | -339.380461 |
|
||
| 17 | -278.517559 |
|
||
| 18 | -163.068718 |
|
||
| 19 | -29.279622 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -21659.122712 |
|
-29314.662025 |
|
| 2 | -2215.90066 |
|
-1348.703025 |
|
| 3 | -2120.478696 |
|
-1106.439955 |
|
| 4 | -1836.441528 |
|
-1005.613652 |
|
| 5 | -1811.32141 |
|
-533.859113 |
|
| 6 | -1046.098463 |
|
-337.176547 |
|
| 7 | -826.646134 |
|
-311.460343 |
|
| 8 | -738.39313 |
|
-238.678414 |
|
| 9 | -670.031377 |
|
-213.339124 |
|
| 10 | -588.73272 |
|
-141.934684 |
|
| 11 | -435.975887 |
|
-121.219702 |
|
| 12 | -424.285656 |
|
-36.644741 |
|
| 13 | -406.966128 |
|
||
| 14 | -278.658269 |
|
||
| 15 | -198.362328 |
|
||
| 16 | -86.330557 |
|
||
| 17 | -39.819009 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 1.4e-14 |
|
| 3 | 2e-14 |
|
| 4 | 3.2e-12 |
|
| 5 | 0.048 |
|
| 6 | 0.62 |
|
| 7 | 1.2 |
|
| 8 | 1.2 |
|
| 9 | 19.0 |
|
| 10 | 1.6 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 3.2e-92 |
|
0.0017 |
|
| 3 | 8.7e-73 |
|
0.57 |
|
| 4 | 1.5e-28 |
|
17.0 |
|
| 5 | 1.2e-24 |
|
5600.0 |
|
| 6 | 7.5e-12 |
|
840000.0 |
|
| 7 | 0.056 |
|
1000000.0 |
|
| 8 | 0.81 |
|
560000.0 |
|
| 9 | 51.0 |
|
1100000.0 |
|
| 10 | 78.0 |
|
1200000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 7.9e-100 |
|
3e-06 |
|
| 3 | 3.7e-79 |
|
0.00099 |
|
| 4 | 3.9e-44 |
|
6.4 |
|
| 5 | 1.5e-29 |
|
63.0 |
|
| 6 | 3.9e-19 |
|
6100.0 |
|
| 7 | 1.6e-18 |
|
400000.0 |
|
| 8 | 1e-13 |
|
960000.0 |
|
| 9 | 2.1e-11 |
|
1000000.0 |
|
| 10 | 9.2e-06 |
|
1900000.0 |
|