DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1414 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1995 |
|
| 5 | 1411 |
|
| 6 | 733 |
|
| 7 | 374 |
|
| 8 | 229 |
|
| 9 | 145 |
|
| 10 | 103 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 15668 |
|
17535 |
|
| 2 | 454 |
|
493 |
|
| 3 | 553 |
|
123 |
|
| 4 | 157 |
|
||
| 5 | 43 |
|
||
| 6 | 6 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 20000 |
|
16081 |
|
| 2 | 966 |
|
||
| 3 | 144 |
|
||
| 4 | 112 |
|
||
| 5 | 26 |
|
||
| 6 | 2 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -49680.873559 |
|
| 2 | -6032.902523 |
|
| 3 | -5421.123167 |
|
| 4 | -4401.637919 |
|
| 5 | -4376.566335 |
|
| 6 | -3614.552195 |
|
| 7 | -2955.259109 |
|
| 8 | -2593.31641 |
|
| 9 | -2049.42305 |
|
| 10 | -1789.381183 |
|
| 11 | -1659.057391 |
|
| 12 | -1654.357809 |
|
| 13 | -1398.535883 |
|
| 14 | -631.984184 |
|
| 15 | -563.233527 |
|
| 16 | -309.556941 |
|
| 17 | -269.70146 |
|
| 18 | -259.884476 |
|
| 19 | -76.112224 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -18503.574102 |
|
-27334.854873 |
|
| 2 | -2733.871625 |
|
-5328.919952 |
|
| 3 | -1974.891678 |
|
-3960.928576 |
|
| 4 | -1965.197437 |
|
-606.333016 |
|
| 5 | -1302.120725 |
|
-485.66197 |
|
| 6 | -1126.063222 |
|
-393.924247 |
|
| 7 | -1083.136872 |
|
-278.732667 |
|
| 8 | -942.813386 |
|
-259.990258 |
|
| 9 | -776.758597 |
|
-169.101832 |
|
| 10 | -591.022189 |
|
-30.78362 |
|
| 11 | -537.881988 |
|
-27.462445 |
|
| 12 | -512.85049 |
|
||
| 13 | -418.921788 |
|
||
| 14 | -322.373881 |
|
||
| 15 | -272.873659 |
|
||
| 16 | -100.146933 |
|
||
| 17 | -63.954623 |
|
||
| 18 | -34.305201 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -24766.820869 |
|
-30875.637803 |
|
| 2 | -4411.505831 |
|
-2613.90873 |
|
| 3 | -2623.980861 |
|
-1123.559278 |
|
| 4 | -1693.186547 |
|
-708.267874 |
|
| 5 | -1644.577658 |
|
-701.459185 |
|
| 6 | -843.961306 |
|
-484.884816 |
|
| 7 | -837.605523 |
|
-302.876128 |
|
| 8 | -718.43958 |
|
-281.075603 |
|
| 9 | -452.331658 |
|
-129.518208 |
|
| 10 | -452.331658 |
|
-44.07407 |
|
| 11 | -373.773015 |
|
||
| 12 | -362.57033 |
|
||
| 13 | -360.443244 |
|
||
| 14 | -332.263371 |
|
||
| 15 | -277.316375 |
|
||
| 16 | -179.004584 |
|
||
| 17 | -65.885199 |
|
||
| 18 | -35.744341 |
|
||
| 19 | -24.675906 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 0.0 |
|
| 3 | 6.1e-15 |
|
| 4 | 8.3e-11 |
|
| 5 | 0.00092 |
|
| 6 | 0.0025 |
|
| 7 | 0.12 |
|
| 8 | 11.0 |
|
| 9 | 71.0 |
|
| 10 | 320.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2.7e-86 |
|
4.4e-06 |
|
| 3 | 1.6e-43 |
|
25.0 |
|
| 4 | 1.7e-36 |
|
110000.0 |
|
| 5 | 1.9e-21 |
|
290000.0 |
|
| 6 | 3.1e-07 |
|
700000.0 |
|
| 7 | 9.8e-05 |
|
1600000.0 |
|
| 8 | 0.0001 |
|
1700000.0 |
|
| 9 | 0.00059 |
|
1300000.0 |
|
| 10 | 3.6 |
|
1900000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 5.7e-73 |
|
3.2 |
|
| 3 | 2.5e-64 |
|
180.0 |
|
| 4 | 2.5e-23 |
|
3700.0 |
|
| 5 | 1.2e-20 |
|
930000.0 |
|
| 6 | 0.00045 |
|
730000.0 |
|
| 7 | 0.0018 |
|
950000.0 |
|
| 8 | 18000.0 |
|
1400000.0 |
|
| 9 | 140000.0 |
|
1500000.0 |
|
| 10 | 140000.0 |
|
1400000.0 |
|