DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1780 |
|
| 2 | 1996 |
|
| 3 | 2000 |
|
| 4 | 1998 |
|
| 5 | 1844 |
|
| 6 | 1034 |
|
| 7 | 515 |
|
| 8 | 287 |
|
| 9 | 209 |
|
| 10 | 145 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 12852 |
|
14043 |
|
| 2 | 4471 |
|
700 |
|
| 3 | 254 |
|
||
| 4 | 99 |
|
||
| 5 | 25 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 14610 |
|
13269 |
|
| 2 | 886 |
|
675 |
|
| 3 | 177 |
|
252 |
|
| 4 | 46 |
|
10 |
|
| 5 | 12 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -17660.538702 |
|
| 2 | -2018.844722 |
|
| 3 | -1555.924867 |
|
| 4 | -1482.359027 |
|
| 5 | -1199.781044 |
|
| 6 | -1177.59461 |
|
| 7 | -732.193174 |
|
| 8 | -454.528461 |
|
| 9 | -453.471161 |
|
| 10 | -433.064496 |
|
| 11 | -282.771733 |
|
| 12 | -250.0162 |
|
| 13 | -147.530873 |
|
| 14 | -131.540627 |
|
| 15 | -65.187054 |
|
| 16 | -37.102467 |
|
| 17 | -31.140853 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -21460.387178 |
|
-26325.286294 |
|
| 2 | -2338.182203 |
|
-5087.308948 |
|
| 3 | -1833.19689 |
|
-2520.448763 |
|
| 4 | -1740.817431 |
|
-1095.394889 |
|
| 5 | -1464.641104 |
|
-641.030169 |
|
| 6 | -1089.121488 |
|
-550.816857 |
|
| 7 | -884.050272 |
|
-495.625149 |
|
| 8 | -717.831125 |
|
-218.959092 |
|
| 9 | -631.26479 |
|
-191.50374 |
|
| 10 | -612.971344 |
|
-37.580817 |
|
| 11 | -600.817345 |
|
-21.342274 |
|
| 12 | -487.200857 |
|
||
| 13 | -416.454868 |
|
||
| 14 | -399.940482 |
|
||
| 15 | -311.993201 |
|
||
| 16 | -304.397369 |
|
||
| 17 | -162.138028 |
|
||
| 18 | -82.493188 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -25599.581817 |
|
-27843.982725 |
|
| 2 | -8473.589983 |
|
-6544.711778 |
|
| 3 | -1063.062943 |
|
-907.992239 |
|
| 4 | -808.417086 |
|
-359.7437 |
|
| 5 | -316.021993 |
|
-269.922144 |
|
| 6 | -259.493433 |
|
-256.334905 |
|
| 7 | -232.943026 |
|
-240.658039 |
|
| 8 | -176.219687 |
|
-100.241622 |
|
| 9 | -89.897071 |
|
-94.285681 |
|
| 10 | -76.566806 |
|
-80.84829 |
|
| 11 | -28.895595 |
|
-76.536721 |
|
| 12 | -69.082718 |
|
||
| 13 | -67.795039 |
|
||
| 14 | -43.666365 |
|
||
| 15 | -21.279419 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 4.9e-37 |
|
| 3 | 4.5e-18 |
|
| 4 | 7.7e-18 |
|
| 5 | 1.2e-08 |
|
| 6 | 2.3e-09 |
|
| 7 | 1.7e-05 |
|
| 8 | 2.6 |
|
| 9 | 0.031 |
|
| 10 | 0.44 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 4.6e-99 |
|
3.3e-40 |
|
| 3 | 1.3e-79 |
|
1e-63 |
|
| 4 | 1.1e-57 |
|
0.0018 |
|
| 5 | 1.9e-44 |
|
0.11 |
|
| 6 | 1.3e-27 |
|
35.0 |
|
| 7 | 4.7e-27 |
|
3.3 |
|
| 8 | 1.7e-18 |
|
5000.0 |
|
| 9 | 6.4e-14 |
|
38000.0 |
|
| 10 | 6.4e-14 |
|
160000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 8.3e-21 |
|
0.45 |
|
| 3 | 0.0007 |
|
30.0 |
|
| 4 | 0.04 |
|
460.0 |
|
| 5 | 1400.0 |
|
690000.0 |
|
| 6 | 3400.0 |
|
1100000.0 |
|
| 7 | 7700.0 |
|
1200000.0 |
|
| 8 | 190000.0 |
|
1800000.0 |
|
| 9 | 120000.0 |
|
1900000.0 |
|
| 10 | 390000.0 |
|
2300000.0 |
|