DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1781 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1948 |
|
| 5 | 1333 |
|
| 6 | 622 |
|
| 7 | 446 |
|
| 8 | 218 |
|
| 9 | 133 |
|
| 10 | 89 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 7591 |
|
6067 |
|
| 2 | 2092 |
|
361 |
|
| 3 | 787 |
|
252 |
|
| 4 | 77 |
|
||
| 5 | 3 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 6586 |
|
4753 |
|
| 2 | 1071 |
|
427 |
|
| 3 | 189 |
|
73 |
|
| 4 | 6 |
|
10 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -8786.573343 |
|
| 2 | -1652.937016 |
|
| 3 | -1436.146833 |
|
| 4 | -670.426527 |
|
| 5 | -582.857322 |
|
| 6 | -388.068796 |
|
| 7 | -298.578774 |
|
| 8 | -281.768855 |
|
| 9 | -235.847634 |
|
| 10 | -213.654416 |
|
| 11 | -138.134067 |
|
| 12 | -137.375374 |
|
| 13 | -136.767957 |
|
| 14 | -105.252476 |
|
| 15 | -61.136167 |
|
| 16 | -36.995101 |
|
| 17 | -36.25785 |
|
| 18 | -6.490842 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -12208.063485 |
|
-13390.890715 |
|
| 2 | -1590.410906 |
|
-4716.919 |
|
| 3 | -1329.867279 |
|
-1294.427145 |
|
| 4 | -1195.074035 |
|
-840.740384 |
|
| 5 | -1055.979263 |
|
-89.972095 |
|
| 6 | -797.503494 |
|
-67.955192 |
|
| 7 | -734.479342 |
|
-63.689928 |
|
| 8 | -721.959924 |
|
-48.205724 |
|
| 9 | -586.289152 |
|
-47.171698 |
|
| 10 | -562.054864 |
|
||
| 11 | -553.674464 |
|
||
| 12 | -537.965397 |
|
||
| 13 | -449.015963 |
|
||
| 14 | -379.608118 |
|
||
| 15 | -300.936834 |
|
||
| 16 | -284.445135 |
|
||
| 17 | -193.91198 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -13576.905284 |
|
-15029.513238 |
|
| 2 | -3393.385352 |
|
-595.697449 |
|
| 3 | -258.238881 |
|
-365.047507 |
|
| 4 | -157.133533 |
|
-312.252685 |
|
| 5 | -126.108212 |
|
-46.343056 |
|
| 6 | -109.332595 |
|
-18.050718 |
|
| 7 | -53.031723 |
|
||
| 8 | -47.45854 |
|
||
| 9 | -17.770262 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 3.3e-70 |
|
| 3 | 1.7e-32 |
|
| 4 | 210.0 |
|
| 5 | 2100.0 |
|
| 6 | 15000.0 |
|
| 7 | 20000.0 |
|
| 8 | 17000.0 |
|
| 9 | 33000.0 |
|
| 10 | 95000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 6.7e-59 |
|
1.2e-51 |
|
| 3 | 1.8e-54 |
|
8.6e-15 |
|
| 4 | 9.7e-56 |
|
0.06 |
|
| 5 | 3.8e-52 |
|
1.7 |
|
| 6 | 5.8e-40 |
|
5.5 |
|
| 7 | 1.6e-27 |
|
13.0 |
|
| 8 | 4.9e-23 |
|
26000.0 |
|
| 9 | 5.9e-21 |
|
39000.0 |
|
| 10 | 8.2e-20 |
|
160000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.3e-27 |
|
3.2e-05 |
|
| 3 | 1.1e-20 |
|
0.011 |
|
| 4 | 2.3e-13 |
|
5.9 |
|
| 5 | 2.1 |
|
810000.0 |
|
| 6 | 3.1 |
|
1200000.0 |
|
| 7 | 5400.0 |
|
2800000.0 |
|
| 8 | 38000.0 |
|
2800000.0 |
|
| 9 | 460000.0 |
|
2800000.0 |
|
| 10 | 900000.0 |
|
2800000.0 |
|