DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1369 |
|
| 2 | 1999 |
|
| 3 | 2000 |
|
| 4 | 1996 |
|
| 5 | 1980 |
|
| 6 | 1352 |
|
| 7 | 841 |
|
| 8 | 481 |
|
| 9 | 380 |
|
| 10 | 299 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 13958 |
|
6969 |
|
| 2 | 2382 |
|
3528 |
|
| 3 | 144 |
|
4338 |
|
| 4 | 10 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 14333 |
|
5941 |
|
| 2 | 3090 |
|
4558 |
|
| 3 | 13 |
|
3433 |
|
| 4 | 1 |
|
28 |
|
| 5 | 12 |
|
||
| 6 | 3 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -51674.071603 |
|
| 2 | -41018.560745 |
|
| 3 | -5313.841963 |
|
| 4 | -4397.580994 |
|
| 5 | -3988.921054 |
|
| 6 | -3612.725034 |
|
| 7 | -3519.31268 |
|
| 8 | -3121.499821 |
|
| 9 | -1778.741013 |
|
| 10 | -1598.041816 |
|
| 11 | -1437.793026 |
|
| 12 | -809.095008 |
|
| 13 | -783.458751 |
|
| 14 | -620.077953 |
|
| 15 | -614.933676 |
|
| 16 | -539.999219 |
|
| 17 | -236.829406 |
|
| 18 | -206.301778 |
|
| 19 | -70.737002 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -25264.699654 |
|
-28136.923609 |
|
| 2 | -16444.191548 |
|
-20044.181852 |
|
| 3 | -3661.336833 |
|
-1000.611485 |
|
| 4 | -1257.207655 |
|
-718.892344 |
|
| 5 | -634.863451 |
|
-509.273694 |
|
| 6 | -610.537131 |
|
-344.020767 |
|
| 7 | -605.866345 |
|
-155.779695 |
|
| 8 | -479.260874 |
|
-112.284816 |
|
| 9 | -381.167182 |
|
-98.41898 |
|
| 10 | -336.19824 |
|
-43.569237 |
|
| 11 | -330.636724 |
|
||
| 12 | -243.680792 |
|
||
| 13 | -164.397307 |
|
||
| 14 | -135.541628 |
|
||
| 15 | -131.973932 |
|
||
| 16 | -129.622003 |
|
||
| 17 | -99.06632 |
|
||
| 18 | -89.974257 |
|
||
| 19 | -72.274706 |
|
||
| 20 | -39.293527 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -28229.463987 |
|
-27187.284568 |
|
| 2 | -21820.463815 |
|
-19575.765779 |
|
| 3 | -735.526652 |
|
-756.329178 |
|
| 4 | -710.862233 |
|
-414.130924 |
|
| 5 | -646.963261 |
|
-329.573761 |
|
| 6 | -499.629397 |
|
-195.161297 |
|
| 7 | -442.665528 |
|
-145.987523 |
|
| 8 | -318.791527 |
|
-133.293826 |
|
| 9 | -213.768953 |
|
-94.12011 |
|
| 10 | -209.142207 |
|
||
| 11 | -137.109834 |
|
||
| 12 | -102.262761 |
|
||
| 13 | -89.703331 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 0.0 |
|
| 3 | 5.1e-58 |
|
| 4 | 3.2e-41 |
|
| 5 | 2.7e-15 |
|
| 6 | 3e-13 |
|
| 7 | 2.6e-06 |
|
| 8 | 0.00011 |
|
| 9 | 0.043 |
|
| 10 | 0.11 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 0.0 |
|
3.3e-108 |
|
| 3 | 8.2e-71 |
|
7.2e-79 |
|
| 4 | 6.8e-24 |
|
3.6e-10 |
|
| 5 | 9.3e-14 |
|
29.0 |
|
| 6 | 0.025 |
|
190000.0 |
|
| 7 | 430.0 |
|
780000.0 |
|
| 8 | 180000.0 |
|
840000.0 |
|
| 9 | 1200000.0 |
|
1800000.0 |
|
| 10 | 1300000.0 |
|
2500000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 0.0 |
|
0.0 |
|
| 3 | 4.4e-43 |
|
5.6e-102 |
|
| 4 | 2.8e-14 |
|
10000.0 |
|
| 5 | 230.0 |
|
26000.0 |
|
| 6 | 5900.0 |
|
170000.0 |
|
| 7 | 580000.0 |
|
400000.0 |
|
| 8 | 2700000.0 |
|
560000.0 |
|
| 9 | 3500000.0 |
|
1200000.0 |
|
| 10 | 2200000.0 |
|
1400000.0 |
|