DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1826 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1995 |
|
| 5 | 1583 |
|
| 6 | 800 |
|
| 7 | 507 |
|
| 8 | 386 |
|
| 9 | 272 |
|
| 10 | 243 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 5265 |
|
2489 |
|
| 2 | 1471 |
|
920 |
|
| 3 | 131 |
|
||
| 4 | 35 |
|
||
| 5 | 34 |
|
||
| 6 | 9 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 5219 |
|
3158 |
|
| 2 | 897 |
|
370 |
|
| 3 | 234 |
|
55 |
|
| 4 | 126 |
|
11 |
|
| 5 | 39 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -4964.774555 |
|
| 2 | -1438.587963 |
|
| 3 | -1429.645486 |
|
| 4 | -770.003589 |
|
| 5 | -711.882353 |
|
| 6 | -649.615621 |
|
| 7 | -573.579402 |
|
| 8 | -507.895239 |
|
| 9 | -474.394517 |
|
| 10 | -449.484344 |
|
| 11 | -395.576287 |
|
| 12 | -391.937168 |
|
| 13 | -194.676015 |
|
| 14 | -173.850736 |
|
| 15 | -139.370373 |
|
| 16 | -127.903764 |
|
| 17 | -114.735386 |
|
| 18 | -113.607599 |
|
| 19 | -12.478743 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -8825.329372 |
|
-9560.822656 |
|
| 2 | -2422.484288 |
|
-3075.539131 |
|
| 3 | -565.088121 |
|
-186.18106 |
|
| 4 | -457.368683 |
|
-54.631148 |
|
| 5 | -364.559125 |
|
-47.038672 |
|
| 6 | -330.583553 |
|
-47.038672 |
|
| 7 | -326.488303 |
|
-40.248557 |
|
| 8 | -275.110987 |
|
-31.597751 |
|
| 9 | -221.284926 |
|
-30.421588 |
|
| 10 | -195.084536 |
|
-27.287254 |
|
| 11 | -191.311872 |
|
-15.145079 |
|
| 12 | -189.907611 |
|
-1.395492 |
|
| 13 | -149.721689 |
|
||
| 14 | -78.680646 |
|
||
| 15 | -69.452182 |
|
||
| 16 | -55.407728 |
|
||
| 17 | -34.855453 |
|
||
| 18 | -32.512276 |
|
||
| 19 | -6.013197 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -8181.659503 |
|
-7777.227384 |
|
| 2 | -2651.216728 |
|
-2154.828832 |
|
| 3 | -1759.744941 |
|
-1890.278357 |
|
| 4 | -1239.671294 |
|
-1053.152379 |
|
| 5 | -1073.66466 |
|
-1023.942053 |
|
| 6 | -392.214953 |
|
-475.927817 |
|
| 7 | -206.985436 |
|
-152.343089 |
|
| 8 | -114.980871 |
|
-40.61977 |
|
| 9 | -96.142483 |
|
-34.052819 |
|
| 10 | -66.796929 |
|
-28.244646 |
|
| 11 | -28.244646 |
|
||
| 12 | -11.458547 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 1.4e-107 |
|
| 3 | 7.1e-68 |
|
| 4 | 5.5e-46 |
|
| 5 | 6.6e-11 |
|
| 6 | 8.6e-10 |
|
| 7 | 2.8e-06 |
|
| 8 | 0.0065 |
|
| 9 | 83.0 |
|
| 10 | 180.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 7.5e-188 |
|
7.1e-292 |
|
| 3 | 4.9e-47 |
|
280.0 |
|
| 4 | 3.1e-41 |
|
1700000.0 |
|
| 5 | 3e-33 |
|
1800000.0 |
|
| 6 | 6.7e-21 |
|
3300000.0 |
|
| 7 | 2.6e-07 |
|
3400000.0 |
|
| 8 | 0.053 |
|
3900000.0 |
|
| 9 | 0.46 |
|
5400000.0 |
|
| 10 | 1000.0 |
|
5700000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 5.8e-101 |
|
3.1e-175 |
|
| 3 | 7.1e-51 |
|
1.8e-90 |
|
| 4 | 2.2e-49 |
|
2.5e-12 |
|
| 5 | 4e-12 |
|
0.0076 |
|
| 6 | 0.28 |
|
89000.0 |
|
| 7 | 280.0 |
|
1400000.0 |
|
| 8 | 430.0 |
|
1700000.0 |
|
| 9 | 470000.0 |
|
1700000.0 |
|
| 10 | 890000.0 |
|
2700000.0 |
|