DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 1990 |
|
| 4 | 1648 |
|
| 5 | 1060 |
|
| 6 | 353 |
|
| 7 | 153 |
|
| 8 | 125 |
|
| 9 | 102 |
|
| 10 | 45 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 3116 |
|
3300 |
|
| 2 | 1280 |
|
1224 |
|
| 3 | 684 |
|
343 |
|
| 4 | 338 |
|
22 |
|
| 5 | 5 |
|
||
| 6 | 1 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 4954 |
|
6929 |
|
| 2 | 431 |
|
389 |
|
| 3 | 90 |
|
274 |
|
| 4 | 44 |
|
139 |
|
| 5 | 21 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -2542.897598 |
|
| 2 | -2057.785634 |
|
| 3 | -1325.449163 |
|
| 4 | -1220.70749 |
|
| 5 | -1054.411945 |
|
| 6 | -979.255724 |
|
| 7 | -906.256173 |
|
| 8 | -866.459783 |
|
| 9 | -578.867073 |
|
| 10 | -378.524194 |
|
| 11 | -337.392655 |
|
| 12 | -334.531532 |
|
| 13 | -298.382991 |
|
| 14 | -292.312019 |
|
| 15 | -236.606573 |
|
| 16 | -200.308042 |
|
| 17 | -127.836226 |
|
| 18 | -123.297979 |
|
| 19 | -95.8942 |
|
| 20 | -61.399902 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -6334.539807 |
|
-6140.171998 |
|
| 2 | -933.195818 |
|
-1710.539969 |
|
| 3 | -910.999909 |
|
-385.681553 |
|
| 4 | -368.05026 |
|
-284.402655 |
|
| 5 | -277.286084 |
|
-223.970614 |
|
| 6 | -153.663159 |
|
-211.88268 |
|
| 7 | -144.661998 |
|
-195.191855 |
|
| 8 | -141.588101 |
|
-148.617643 |
|
| 9 | -134.812487 |
|
-82.594368 |
|
| 10 | -101.306348 |
|
-48.180403 |
|
| 11 | -78.883094 |
|
-46.07199 |
|
| 12 | -78.450455 |
|
||
| 13 | -77.145025 |
|
||
| 14 | -64.622813 |
|
||
| 15 | -60.961091 |
|
||
| 16 | -23.429356 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -4243.454091 |
|
-5394.047508 |
|
| 2 | -3353.309477 |
|
-3988.33421 |
|
| 3 | -972.409978 |
|
-1052.316639 |
|
| 4 | -963.308981 |
|
-662.026682 |
|
| 5 | -726.5104 |
|
-501.357524 |
|
| 6 | -333.843559 |
|
-210.846558 |
|
| 7 | -315.059715 |
|
-193.828731 |
|
| 8 | -289.392197 |
|
-115.075698 |
|
| 9 | -106.063044 |
|
-76.229208 |
|
| 10 | -91.227366 |
|
-39.809366 |
|
| 11 | -32.594406 |
|
-24.931876 |
|
| 12 | -13.661619 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 2.6e-85 |
|
| 2 | 1.6e-89 |
|
| 3 | 8.9e-53 |
|
| 4 | 3.2e-28 |
|
| 5 | 9e-23 |
|
| 6 | 3.1e-20 |
|
| 7 | 6.8e-06 |
|
| 8 | 0.14 |
|
| 9 | 0.2 |
|
| 10 | 5.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 5.7e-52 |
|
1.9e-145 |
|
| 3 | 2e-48 |
|
7.4e-121 |
|
| 4 | 1.4e-35 |
|
6.8e-06 |
|
| 5 | 2.1e-31 |
|
0.00029 |
|
| 6 | 3.3e-12 |
|
230.0 |
|
| 7 | 7.2e-05 |
|
20000.0 |
|
| 8 | 0.004 |
|
32000.0 |
|
| 9 | 0.31 |
|
720000.0 |
|
| 10 | 0.51 |
|
770000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.1e-268 |
|
1.4e-194 |
|
| 3 | 2e-34 |
|
2.5e-23 |
|
| 4 | 1.1e-20 |
|
0.0087 |
|
| 5 | 1.8e-12 |
|
170.0 |
|
| 6 | 8.7e-05 |
|
380.0 |
|
| 7 | 340.0 |
|
86000.0 |
|
| 8 | 2.0 |
|
150000.0 |
|
| 9 | 39000.0 |
|
150000.0 |
|
| 10 | 63000.0 |
|
190000.0 |
|