DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1998 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1923 |
|
| 5 | 1327 |
|
| 6 | 672 |
|
| 7 | 381 |
|
| 8 | 156 |
|
| 9 | 93 |
|
| 10 | 56 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 10690 |
|
6944 |
|
| 2 | 1891 |
|
2060 |
|
| 3 | 1234 |
|
434 |
|
| 4 | 282 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 10103 |
|
7084 |
|
| 2 | 3886 |
|
2426 |
|
| 3 | 762 |
|
420 |
|
| 4 | 60 |
|
||
| 5 | 13 |
|
||
| 6 | 1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -15847.863335 |
|
| 2 | -2023.326472 |
|
| 3 | -1938.129904 |
|
| 4 | -1732.032244 |
|
| 5 | -1502.11294 |
|
| 6 | -1189.478365 |
|
| 7 | -1030.410579 |
|
| 8 | -811.908444 |
|
| 9 | -781.3746 |
|
| 10 | -780.72586 |
|
| 11 | -590.097214 |
|
| 12 | -554.758249 |
|
| 13 | -495.364906 |
|
| 14 | -329.134856 |
|
| 15 | -252.136044 |
|
| 16 | -207.998059 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -26043.595074 |
|
-27936.79642 |
|
| 2 | -965.708362 |
|
-997.904711 |
|
| 3 | -878.702869 |
|
-190.247932 |
|
| 4 | -498.736057 |
|
-185.177587 |
|
| 5 | -239.147897 |
|
-176.366583 |
|
| 6 | -218.446785 |
|
-134.036886 |
|
| 7 | -210.942266 |
|
-116.339924 |
|
| 8 | -202.837644 |
|
-83.719101 |
|
| 9 | -182.317174 |
|
-75.989308 |
|
| 10 | -177.242172 |
|
-50.243795 |
|
| 11 | -157.674468 |
|
-42.791411 |
|
| 12 | -147.295995 |
|
-20.762386 |
|
| 13 | -130.539369 |
|
||
| 14 | -92.138315 |
|
||
| 15 | -92.137345 |
|
||
| 16 | -90.486965 |
|
||
| 17 | -76.414426 |
|
||
| 18 | -14.543889 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -26732.612215 |
|
-30050.052766 |
|
| 2 | -1743.112738 |
|
-1720.824343 |
|
| 3 | -1294.234915 |
|
-489.707497 |
|
| 4 | -1292.065526 |
|
-346.236024 |
|
| 5 | -519.426384 |
|
-265.445269 |
|
| 6 | -494.155074 |
|
-150.273799 |
|
| 7 | -391.19714 |
|
-124.780371 |
|
| 8 | -218.456961 |
|
-124.780371 |
|
| 9 | -162.966885 |
|
-71.939661 |
|
| 10 | -113.274518 |
|
-67.641878 |
|
| 11 | -95.041064 |
|
-40.143544 |
|
| 12 | -90.492827 |
|
||
| 13 | -80.86595 |
|
||
| 14 | -68.37447 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 4.7e-116 |
|
| 3 | 1.9e-56 |
|
| 4 | 1.6e-31 |
|
| 5 | 4.6e-17 |
|
| 6 | 2.4e-09 |
|
| 7 | 2.1e-08 |
|
| 8 | 4.3e-05 |
|
| 9 | 2.4e-06 |
|
| 10 | 0.0077 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 3.8e-19 |
|
9.2e-28 |
|
| 3 | 2.9e-10 |
|
0.97 |
|
| 4 | 2.3 |
|
7.0 |
|
| 5 | 47.0 |
|
58.0 |
|
| 6 | 110000.0 |
|
13000.0 |
|
| 7 | 660000.0 |
|
14000.0 |
|
| 8 | 760000.0 |
|
200000.0 |
|
| 9 | 1600000.0 |
|
420000.0 |
|
| 10 | 3000000.0 |
|
1500000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 4.2e-57 |
|
8.8e-73 |
|
| 3 | 7.5e-06 |
|
2.1e-14 |
|
| 4 | 0.4 |
|
0.002 |
|
| 5 | 23.0 |
|
29000.0 |
|
| 6 | 140.0 |
|
320000.0 |
|
| 7 | 370.0 |
|
2100000.0 |
|
| 8 | 970.0 |
|
1400000.0 |
|
| 9 | 90000.0 |
|
4400000.0 |
|
| 10 | 260000.0 |
|
5700000.0 |
|