DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1994 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1985 |
|
| 5 | 1257 |
|
| 6 | 698 |
|
| 7 | 336 |
|
| 8 | 139 |
|
| 9 | 47 |
|
| 10 | 1 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 15233 |
|
12596 |
|
| 2 | 1595 |
|
5066 |
|
| 3 | 546 |
|
1000 |
|
| 4 | 157 |
|
201 |
|
| 5 | 49 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 14663 |
|
11664 |
|
| 2 | 1945 |
|
6530 |
|
| 3 | 765 |
|
571 |
|
| 4 | 310 |
|
227 |
|
| 5 | 53 |
|
85 |
|
| 6 | 16 |
|
27 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -44964.062225 |
|
| 2 | -7784.904282 |
|
| 3 | -6362.47388 |
|
| 4 | -3469.724962 |
|
| 5 | -3249.537391 |
|
| 6 | -3189.499274 |
|
| 7 | -3080.976416 |
|
| 8 | -2739.940122 |
|
| 9 | -1423.092244 |
|
| 10 | -1295.474771 |
|
| 11 | -1277.562541 |
|
| 12 | -1086.653284 |
|
| 13 | -880.8432 |
|
| 14 | -676.619463 |
|
| 15 | -390.633017 |
|
| 16 | -343.639083 |
|
| 17 | -285.585775 |
|
| 18 | -211.673445 |
|
| 19 | -199.6982 |
|
| 20 | -196.174396 |
|
| 21 | -167.177014 |
|
| 22 | -108.069554 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -30946.496977 |
|
-51436.946443 |
|
| 2 | -1150.94794 |
|
-1722.754963 |
|
| 3 | -503.619555 |
|
-839.015677 |
|
| 4 | -471.816338 |
|
-231.082537 |
|
| 5 | -169.231885 |
|
-174.741048 |
|
| 6 | -155.806142 |
|
-93.217588 |
|
| 7 | -150.318024 |
|
-89.042175 |
|
| 8 | -141.942525 |
|
-79.625301 |
|
| 9 | -127.444889 |
|
-70.195515 |
|
| 10 | -113.09231 |
|
-46.614346 |
|
| 11 | -108.952427 |
|
-43.18483 |
|
| 12 | -104.278808 |
|
-38.813469 |
|
| 13 | -90.175715 |
|
||
| 14 | -21.058226 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -27779.871584 |
|
-57840.033394 |
|
| 2 | -2240.756682 |
|
-1715.438435 |
|
| 3 | -704.840414 |
|
-723.333826 |
|
| 4 | -702.256406 |
|
-424.007217 |
|
| 5 | -445.299 |
|
-181.169869 |
|
| 6 | -205.074756 |
|
-145.506412 |
|
| 7 | -182.252055 |
|
-132.777083 |
|
| 8 | -138.12075 |
|
-111.849804 |
|
| 9 | -131.934025 |
|
-107.745975 |
|
| 10 | -127.139559 |
|
-91.629655 |
|
| 11 | -119.739413 |
|
-76.028074 |
|
| 12 | -112.770864 |
|
-44.857514 |
|
| 13 | -43.943255 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 1.4e-64 |
|
| 3 | 9.9e-28 |
|
| 4 | 2.7e-25 |
|
| 5 | 1.2e-16 |
|
| 6 | 1.6e-07 |
|
| 7 | 0.21 |
|
| 8 | 7.9 |
|
| 9 | 40.0 |
|
| 10 | 260.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 5.6e-07 |
|
7.7e-39 |
|
| 3 | 0.00044 |
|
3.8e-22 |
|
| 4 | 61000.0 |
|
91000.0 |
|
| 5 | 200000.0 |
|
670000.0 |
|
| 6 | 230000.0 |
|
1300000.0 |
|
| 7 | 500000.0 |
|
1500000.0 |
|
| 8 | 590000.0 |
|
1600000.0 |
|
| 9 | 620000.0 |
|
2300000.0 |
|
| 10 | 420000.0 |
|
2400000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 8.3e-24 |
|
0.00011 |
|
| 3 | 2.3e-10 |
|
0.068 |
|
| 4 | 960.0 |
|
19000.0 |
|
| 5 | 47000.0 |
|
99000.0 |
|
| 6 | 55000.0 |
|
730000.0 |
|
| 7 | 130000.0 |
|
1100000.0 |
|
| 8 | 75000.0 |
|
3200000.0 |
|
| 9 | 160000.0 |
|
2000000.0 |
|
| 10 | 300000.0 |
|
3400000.0 |
|