DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1973 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1590 |
|
| 6 | 1037 |
|
| 7 | 309 |
|
| 8 | 204 |
|
| 9 | 113 |
|
| 10 | 69 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 15249 |
|
12196 |
|
| 2 | 1973 |
|
4736 |
|
| 3 | 876 |
|
1886 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 16525 |
|
10507 |
|
| 2 | 890 |
|
7336 |
|
| 3 | 413 |
|
621 |
|
| 4 | 207 |
|
57 |
|
| 5 | 71 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -39237.414075 |
|
| 2 | -5805.914146 |
|
| 3 | -5697.907448 |
|
| 4 | -3693.369344 |
|
| 5 | -3665.749334 |
|
| 6 | -3640.358357 |
|
| 7 | -3090.081214 |
|
| 8 | -2375.924607 |
|
| 9 | -1891.328485 |
|
| 10 | -1606.540541 |
|
| 11 | -1543.077613 |
|
| 12 | -1296.749967 |
|
| 13 | -1089.95991 |
|
| 14 | -830.225688 |
|
| 15 | -780.462404 |
|
| 16 | -593.696972 |
|
| 17 | -476.933091 |
|
| 18 | -278.51172 |
|
| 19 | -133.351758 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -40207.748201 |
|
-54024.383719 |
|
| 2 | -1595.04051 |
|
-1653.178645 |
|
| 3 | -1019.701547 |
|
-1416.189433 |
|
| 4 | -1005.213916 |
|
-809.044276 |
|
| 5 | -630.3491 |
|
-332.138962 |
|
| 6 | -329.971283 |
|
-327.902643 |
|
| 7 | -293.215544 |
|
-205.145716 |
|
| 8 | -186.066875 |
|
-189.837288 |
|
| 9 | -160.031236 |
|
-174.722936 |
|
| 10 | -156.169914 |
|
-136.626896 |
|
| 11 | -131.661023 |
|
-125.930835 |
|
| 12 | -117.392488 |
|
-125.930835 |
|
| 13 | -116.642653 |
|
-101.683795 |
|
| 14 | -94.262702 |
|
-98.04754 |
|
| 15 | -89.744826 |
|
-67.209118 |
|
| 16 | -76.433149 |
|
-51.076628 |
|
| 17 | -55.168214 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -36274.194071 |
|
-43764.365037 |
|
| 2 | -1334.826157 |
|
-2919.228164 |
|
| 3 | -902.532045 |
|
-1533.12943 |
|
| 4 | -494.686175 |
|
-891.873076 |
|
| 5 | -480.662227 |
|
-529.744394 |
|
| 6 | -403.301165 |
|
-379.140818 |
|
| 7 | -269.952124 |
|
-304.156683 |
|
| 8 | -210.010832 |
|
-175.279059 |
|
| 9 | -186.444471 |
|
-140.754701 |
|
| 10 | -184.47794 |
|
-127.508451 |
|
| 11 | -98.860839 |
|
-116.906274 |
|
| 12 | -94.303612 |
|
-108.931775 |
|
| 13 | -89.784146 |
|
-101.765257 |
|
| 14 | -72.727783 |
|
||
| 15 | -47.06605 |
|
||
| 16 | -46.350615 |
|
||
| 17 | -28.243803 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 5.4e-173 |
|
| 3 | 7.2e-34 |
|
| 4 | 7.6e-26 |
|
| 5 | 1.2e-23 |
|
| 6 | 2.7e-20 |
|
| 7 | 5.3e-17 |
|
| 8 | 0.0018 |
|
| 9 | 8.7e-06 |
|
| 10 | 0.044 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 7.1e-24 |
|
3.5e-43 |
|
| 3 | 0.0013 |
|
1.7e-31 |
|
| 4 | 13.0 |
|
6.3e-11 |
|
| 5 | 750.0 |
|
1.6e-10 |
|
| 6 | 7200.0 |
|
1.4 |
|
| 7 | 15000.0 |
|
5.8 |
|
| 8 | 29000.0 |
|
350.0 |
|
| 9 | 470000.0 |
|
1000.0 |
|
| 10 | 1000000.0 |
|
17000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 5.9e-16 |
|
7.3e-18 |
|
| 3 | 5.1e-10 |
|
0.00079 |
|
| 4 | 0.86 |
|
23.0 |
|
| 5 | 2.5 |
|
430.0 |
|
| 6 | 1.6 |
|
3600.0 |
|
| 7 | 17.0 |
|
5400.0 |
|
| 8 | 400.0 |
|
74000.0 |
|
| 9 | 7800.0 |
|
130000.0 |
|
| 10 | 53000.0 |
|
150000.0 |
|