DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1992 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1960 |
|
| 5 | 1302 |
|
| 6 | 718 |
|
| 7 | 422 |
|
| 8 | 240 |
|
| 9 | 159 |
|
| 10 | 114 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 11588 |
|
8259 |
|
| 2 | 3974 |
|
1998 |
|
| 3 | 898 |
|
510 |
|
| 4 | 303 |
|
||
| 5 | 72 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 10843 |
|
8924 |
|
| 2 | 3496 |
|
3280 |
|
| 3 | 1074 |
|
1274 |
|
| 4 | 296 |
|
||
| 5 | 139 |
|
||
| 6 | 89 |
|
||
| 7 | 10 |
|
||
| 8 | 6 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -18216.633581 |
|
| 2 | -2814.444974 |
|
| 3 | -2595.463122 |
|
| 4 | -1952.462896 |
|
| 5 | -1774.935932 |
|
| 6 | -1462.042248 |
|
| 7 | -1175.225533 |
|
| 8 | -1114.641505 |
|
| 9 | -1073.262042 |
|
| 10 | -1018.855211 |
|
| 11 | -935.870045 |
|
| 12 | -641.785341 |
|
| 13 | -620.416419 |
|
| 14 | -591.403771 |
|
| 15 | -484.710008 |
|
| 16 | -347.569743 |
|
| 17 | -261.628323 |
|
| 18 | -223.366887 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -27516.496472 |
|
-36339.335639 |
|
| 2 | -1802.885016 |
|
-2392.361199 |
|
| 3 | -800.450694 |
|
-585.114909 |
|
| 4 | -718.888813 |
|
-390.902665 |
|
| 5 | -687.842393 |
|
-130.314522 |
|
| 6 | -493.607655 |
|
-122.771009 |
|
| 7 | -490.268633 |
|
-102.300666 |
|
| 8 | -409.332322 |
|
-75.561393 |
|
| 9 | -378.388228 |
|
-53.555032 |
|
| 10 | -366.533271 |
|
-33.093058 |
|
| 11 | -321.180733 |
|
||
| 12 | -192.957249 |
|
||
| 13 | -177.630348 |
|
||
| 14 | -95.271553 |
|
||
| 15 | -68.551833 |
|
||
| 16 | -55.824414 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -20996.04522 |
|
-36031.786514 |
|
| 2 | -2846.940946 |
|
-3013.023096 |
|
| 3 | -1565.302111 |
|
-1324.993178 |
|
| 4 | -918.649663 |
|
-825.760002 |
|
| 5 | -628.698675 |
|
-709.636866 |
|
| 6 | -557.359442 |
|
-596.490743 |
|
| 7 | -537.697089 |
|
-242.949415 |
|
| 8 | -522.713757 |
|
-133.045088 |
|
| 9 | -368.0478 |
|
-131.525778 |
|
| 10 | -368.0478 |
|
-126.743173 |
|
| 11 | -257.177466 |
|
-65.065909 |
|
| 12 | -257.177466 |
|
-51.009951 |
|
| 13 | -232.901011 |
|
-21.892039 |
|
| 14 | -219.893555 |
|
||
| 15 | -193.839921 |
|
||
| 16 | -193.839921 |
|
||
| 17 | -189.347687 |
|
||
| 18 | -131.823056 |
|
||
| 19 | -76.998219 |
|
||
| 20 | -21.829425 |
|
||
| 21 | -16.070194 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 1.1e-110 |
|
| 3 | 1.4e-24 |
|
| 4 | 0.0028 |
|
| 5 | 1.5e-07 |
|
| 6 | 0.0063 |
|
| 7 | 2.5 |
|
| 8 | 3.4 |
|
| 9 | 36.0 |
|
| 10 | 80.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 4.2e-65 |
|
3.1e-102 |
|
| 3 | 1.9e-26 |
|
370.0 |
|
| 4 | 0.018 |
|
83000.0 |
|
| 5 | 0.025 |
|
850000.0 |
|
| 6 | 7.0 |
|
4000000.0 |
|
| 7 | 1600.0 |
|
6500000.0 |
|
| 8 | 2500.0 |
|
7400000.0 |
|
| 9 | 16000.0 |
|
9600000.0 |
|
| 10 | 200000.0 |
|
9700000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 6.9e-67 |
|
1.1e-38 |
|
| 3 | 2.5e-62 |
|
1.7e-33 |
|
| 4 | 4.8e-41 |
|
830000.0 |
|
| 5 | 2.4e-15 |
|
1800000.0 |
|
| 6 | 8.3e-09 |
|
3200000.0 |
|
| 7 | 1.2e-06 |
|
4600000.0 |
|
| 8 | 2.7e-06 |
|
4800000.0 |
|
| 9 | 30.0 |
|
6100000.0 |
|
| 10 | 470.0 |
|
7800000.0 |
|