DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1724 |
|
| 5 | 969 |
|
| 6 | 580 |
|
| 7 | 269 |
|
| 8 | 210 |
|
| 9 | 113 |
|
| 10 | 94 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 5203 |
|
5160 |
|
| 2 | 3059 |
|
2866 |
|
| 3 | 912 |
|
225 |
|
| 4 | 80 |
|
||
| 5 | 6 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 5305 |
|
4937 |
|
| 2 | 3362 |
|
1911 |
|
| 3 | 475 |
|
571 |
|
| 4 | 23 |
|
110 |
|
| 5 | 44 |
|
||
| 6 | 6 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -5489.878869 |
|
| 2 | -1892.001236 |
|
| 3 | -1310.06995 |
|
| 4 | -1222.428077 |
|
| 5 | -1112.243353 |
|
| 6 | -1090.06341 |
|
| 7 | -968.48375 |
|
| 8 | -907.402511 |
|
| 9 | -861.033884 |
|
| 10 | -794.674848 |
|
| 11 | -747.127378 |
|
| 12 | -624.27344 |
|
| 13 | -466.95306 |
|
| 14 | -387.914673 |
|
| 15 | -339.614582 |
|
| 16 | -320.248467 |
|
| 17 | -308.95654 |
|
| 18 | -237.212205 |
|
| 19 | -223.955856 |
|
| 20 | -151.299396 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -9286.625562 |
|
-9984.949241 |
|
| 2 | -2906.73133 |
|
-3451.427482 |
|
| 3 | -721.511632 |
|
-886.257017 |
|
| 4 | -485.012176 |
|
-450.365971 |
|
| 5 | -423.825372 |
|
-182.43954 |
|
| 6 | -388.984648 |
|
-141.741404 |
|
| 7 | -342.289424 |
|
-100.797278 |
|
| 8 | -315.071591 |
|
-96.570002 |
|
| 9 | -277.144643 |
|
-79.722737 |
|
| 10 | -191.804461 |
|
-74.99932 |
|
| 11 | -185.607083 |
|
-68.560841 |
|
| 12 | -170.224401 |
|
-53.733475 |
|
| 13 | -155.357873 |
|
-49.756085 |
|
| 14 | -122.772972 |
|
-48.18633 |
|
| 15 | -83.21423 |
|
-42.688495 |
|
| 16 | -61.17818 |
|
||
| 17 | -59.945269 |
|
||
| 18 | -19.289486 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -8604.217329 |
|
-9680.17262 |
|
| 2 | -2896.275069 |
|
-3096.715708 |
|
| 3 | -994.987023 |
|
-1139.292773 |
|
| 4 | -533.647199 |
|
-311.883563 |
|
| 5 | -532.867838 |
|
-269.189256 |
|
| 6 | -146.665407 |
|
-233.097232 |
|
| 7 | -119.903715 |
|
-223.097105 |
|
| 8 | -119.903715 |
|
-178.435116 |
|
| 9 | -115.310215 |
|
-168.577614 |
|
| 10 | -94.056175 |
|
-134.283073 |
|
| 11 | -92.239965 |
|
-115.171877 |
|
| 12 | -91.763823 |
|
-103.521682 |
|
| 13 | -90.062565 |
|
-102.611063 |
|
| 14 | -86.519518 |
|
-60.689109 |
|
| 15 | -82.683558 |
|
-34.323185 |
|
| 16 | -69.387786 |
|
-13.552763 |
|
| 17 | -63.927279 |
|
||
| 18 | -53.306773 |
|
||
| 19 | -52.357985 |
|
||
| 20 | -21.554446 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 2e-182 |
|
| 2 | 1.4e-69 |
|
| 3 | 7.5e-35 |
|
| 4 | 7e-33 |
|
| 5 | 1.3e-19 |
|
| 6 | 3.7e-09 |
|
| 7 | 7.1e-07 |
|
| 8 | 0.034 |
|
| 9 | 0.00049 |
|
| 10 | 0.035 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 7.4e-108 |
|
1.5e-166 |
|
| 3 | 1.3e-95 |
|
3.9e-138 |
|
| 4 | 1e-44 |
|
0.00064 |
|
| 5 | 5.6e-29 |
|
1100.0 |
|
| 6 | 8e-06 |
|
15000.0 |
|
| 7 | 1.6e-05 |
|
26000.0 |
|
| 8 | 0.027 |
|
130000.0 |
|
| 9 | 31.0 |
|
330000.0 |
|
| 10 | 58.0 |
|
390000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 7.4e-159 |
|
7.8e-184 |
|
| 3 | 1.3e-15 |
|
2.9e-55 |
|
| 4 | 2.4e-13 |
|
1.2e-16 |
|
| 5 | 1.9e-11 |
|
1.5e-07 |
|
| 6 | 6.7e-06 |
|
3.9 |
|
| 7 | 3.1 |
|
6900.0 |
|
| 8 | 250.0 |
|
680.0 |
|
| 9 | 3800.0 |
|
10000.0 |
|
| 10 | 14000.0 |
|
28000.0 |
|