DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1631 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1977 |
|
| 6 | 1400 |
|
| 7 | 719 |
|
| 8 | 398 |
|
| 9 | 270 |
|
| 10 | 184 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 10293 |
|
10381 |
|
| 2 | 3646 |
|
3564 |
|
| 3 | 2238 |
|
1035 |
|
| 4 | 226 |
|
||
| 5 | 174 |
|
||
| 6 | 49 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 8289 |
|
6899 |
|
| 2 | 3622 |
|
7243 |
|
| 3 | 284 |
|
903 |
|
| 4 | 349 |
|
190 |
|
| 5 | 40 |
|
||
| 6 | 11 |
|
||
| 7 | 1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -8557.304323 |
|
| 2 | -8270.778321 |
|
| 3 | -7750.93572 |
|
| 4 | -5576.285561 |
|
| 5 | -4835.116214 |
|
| 6 | -4318.242585 |
|
| 7 | -4253.004818 |
|
| 8 | -2756.924667 |
|
| 9 | -2605.562257 |
|
| 10 | -2454.571333 |
|
| 11 | -2253.761979 |
|
| 12 | -2188.483989 |
|
| 13 | -1879.205013 |
|
| 14 | -1866.035449 |
|
| 15 | -1224.515505 |
|
| 16 | -1038.157426 |
|
| 17 | -824.421472 |
|
| 18 | -767.235782 |
|
| 19 | -53.004361 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -22031.310365 |
|
-24143.978343 |
|
| 2 | -4742.197811 |
|
-6423.783341 |
|
| 3 | -811.789367 |
|
-1522.565653 |
|
| 4 | -443.045531 |
|
-800.302405 |
|
| 5 | -329.070462 |
|
-499.342606 |
|
| 6 | -281.829257 |
|
-357.564648 |
|
| 7 | -267.958885 |
|
-335.233163 |
|
| 8 | -235.490636 |
|
-184.602845 |
|
| 9 | -172.095739 |
|
-163.744109 |
|
| 10 | -158.155208 |
|
-134.02333 |
|
| 11 | -133.527094 |
|
-103.193306 |
|
| 12 | -127.097971 |
|
-87.454711 |
|
| 13 | -100.297271 |
|
-34.579683 |
|
| 14 | -93.808741 |
|
-21.93734 |
|
| 15 | -87.668779 |
|
||
| 16 | -57.229738 |
|
||
| 17 | -35.999846 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -9115.819172 |
|
-12807.21582 |
|
| 2 | -8113.92155 |
|
-10995.710144 |
|
| 3 | -5303.312684 |
|
-6296.981186 |
|
| 4 | -2739.985622 |
|
-2928.481488 |
|
| 5 | -1736.851724 |
|
-2496.391192 |
|
| 6 | -1102.399064 |
|
-1422.364307 |
|
| 7 | -891.066577 |
|
-559.968251 |
|
| 8 | -792.987231 |
|
-546.86655 |
|
| 9 | -477.145627 |
|
-365.278744 |
|
| 10 | -364.285571 |
|
-258.873761 |
|
| 11 | -192.170066 |
|
-205.602322 |
|
| 12 | -105.730487 |
|
-50.525517 |
|
| 13 | -104.321568 |
|
||
| 14 | -29.215077 |
|
||
| 15 | -3.549076 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 1.9e-157 |
|
| 2 | 2.5e-53 |
|
| 3 | 7.6e-53 |
|
| 4 | 1.6e-52 |
|
| 5 | 4.9e-30 |
|
| 6 | 4.4e-30 |
|
| 7 | 2.6e-20 |
|
| 8 | 4.5e-16 |
|
| 9 | 4.3e-11 |
|
| 10 | 8.3e-06 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.2e-89 |
|
1.5e-256 |
|
| 3 | 0.022 |
|
2.5e-111 |
|
| 4 | 53.0 |
|
3.3e-32 |
|
| 5 | 89.0 |
|
2e-13 |
|
| 6 | 230.0 |
|
9100.0 |
|
| 7 | 8000.0 |
|
31000.0 |
|
| 8 | 13000.0 |
|
93000.0 |
|
| 9 | 6100.0 |
|
560000.0 |
|
| 10 | 15000.0 |
|
940000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 3.8e-209 |
|
0.0 |
|
| 2 | 1.3e-212 |
|
6.4e-312 |
|
| 3 | 7.2e-84 |
|
1.7e-79 |
|
| 4 | 1.6e-35 |
|
1.5e-54 |
|
| 5 | 0.0002 |
|
6.9e-05 |
|
| 6 | 0.74 |
|
0.0054 |
|
| 7 | 11.0 |
|
3.2 |
|
| 8 | 1600.0 |
|
690000.0 |
|
| 9 | 4400.0 |
|
1300000.0 |
|
| 10 | 25000.0 |
|
3700000.0 |
|