DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1412 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1990 |
|
| 6 | 1392 |
|
| 7 | 833 |
|
| 8 | 374 |
|
| 9 | 149 |
|
| 10 | 126 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 9118 |
|
6396 |
|
| 2 | 2986 |
|
3538 |
|
| 3 | 820 |
|
1022 |
|
| 4 | 20 |
|
118 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 9322 |
|
5366 |
|
| 2 | 4576 |
|
6031 |
|
| 3 | 496 |
|
290 |
|
| 4 | 87 |
|
45 |
|
| 5 | 4 |
|
3 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -8472.99567 |
|
| 2 | -4799.539847 |
|
| 3 | -3636.141527 |
|
| 4 | -3214.97813 |
|
| 5 | -3191.74423 |
|
| 6 | -2267.552725 |
|
| 7 | -2158.961656 |
|
| 8 | -1890.698981 |
|
| 9 | -1633.683107 |
|
| 10 | -1616.055545 |
|
| 11 | -1518.333571 |
|
| 12 | -1450.704164 |
|
| 13 | -1106.324977 |
|
| 14 | -1068.682078 |
|
| 15 | -710.041666 |
|
| 16 | -440.411504 |
|
| 17 | -425.408653 |
|
| 18 | -395.783864 |
|
| 19 | -274.840123 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -18536.476902 |
|
-19875.059763 |
|
| 2 | -4784.089873 |
|
-5454.629907 |
|
| 3 | -590.602854 |
|
-381.215219 |
|
| 4 | -525.620228 |
|
-234.624811 |
|
| 5 | -362.291941 |
|
-218.817246 |
|
| 6 | -295.234294 |
|
-156.814828 |
|
| 7 | -294.879317 |
|
-130.582696 |
|
| 8 | -235.703163 |
|
-113.77583 |
|
| 9 | -209.35613 |
|
-100.614978 |
|
| 10 | -178.414016 |
|
-95.218396 |
|
| 11 | -178.414016 |
|
-77.459674 |
|
| 12 | -153.476473 |
|
-43.582659 |
|
| 13 | -153.279506 |
|
||
| 14 | -133.600985 |
|
||
| 15 | -95.741961 |
|
||
| 16 | -89.64448 |
|
||
| 17 | -68.912209 |
|
||
| 18 | -28.5058 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -12870.749928 |
|
-17585.941443 |
|
| 2 | -8109.957362 |
|
-8050.852897 |
|
| 3 | -6070.026449 |
|
-5929.515381 |
|
| 4 | -1590.754412 |
|
-541.417951 |
|
| 5 | -314.422727 |
|
-520.043254 |
|
| 6 | -241.465549 |
|
-198.417388 |
|
| 7 | -218.625553 |
|
-195.682382 |
|
| 8 | -182.112992 |
|
-172.64996 |
|
| 9 | -163.637613 |
|
-105.608405 |
|
| 10 | -140.518541 |
|
-104.547365 |
|
| 11 | -109.30613 |
|
-35.755825 |
|
| 12 | -73.781512 |
|
||
| 13 | -70.539012 |
|
||
| 14 | -52.135316 |
|
||
| 15 | -6.128815 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 4.6e-130 |
|
| 2 | 2.4e-56 |
|
| 3 | 1.7e-51 |
|
| 4 | 1e-45 |
|
| 5 | 4.5e-38 |
|
| 6 | 5.1e-26 |
|
| 7 | 3.9e-15 |
|
| 8 | 1.2e-11 |
|
| 9 | 3.9e-07 |
|
| 10 | 4.4e-06 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.3e-95 |
|
2e-255 |
|
| 3 | 3e-17 |
|
5.7e-149 |
|
| 4 | 8.1e-10 |
|
0.00021 |
|
| 5 | 0.15 |
|
25.0 |
|
| 6 | 13000.0 |
|
93000.0 |
|
| 7 | 9600.0 |
|
530000.0 |
|
| 8 | 140000.0 |
|
580000.0 |
|
| 9 | 820000.0 |
|
2800000.0 |
|
| 10 | 1900000.0 |
|
2800000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2.8e-111 |
|
8.3e-321 |
|
| 3 | 4.7e-88 |
|
3.2e-169 |
|
| 4 | 4.9e-55 |
|
650.0 |
|
| 5 | 1.8e-08 |
|
4000.0 |
|
| 6 | 0.0071 |
|
42000.0 |
|
| 7 | 5900.0 |
|
1700000.0 |
|
| 8 | 54000.0 |
|
2100000.0 |
|
| 9 | 56000.0 |
|
2200000.0 |
|
| 10 | 28000.0 |
|
2500000.0 |
|