DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1428 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1735 |
|
| 6 | 915 |
|
| 7 | 386 |
|
| 8 | 270 |
|
| 9 | 114 |
|
| 10 | 55 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 13903 |
|
12315 |
|
| 2 | 2603 |
|
5367 |
|
| 3 | 1062 |
|
638 |
|
| 4 | 437 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 14040 |
|
14601 |
|
| 2 | 2037 |
|
2260 |
|
| 3 | 2509 |
|
1078 |
|
| 4 | 147 |
|
||
| 5 | 48 |
|
||
| 6 | 42 |
|
||
| 7 | 2 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -62997.417514 |
|
| 2 | -5341.741045 |
|
| 3 | -4093.243088 |
|
| 4 | -3088.154767 |
|
| 5 | -2937.660151 |
|
| 6 | -2594.001987 |
|
| 7 | -2150.840272 |
|
| 8 | -1559.58877 |
|
| 9 | -1547.112774 |
|
| 10 | -687.836399 |
|
| 11 | -597.075241 |
|
| 12 | -503.213986 |
|
| 13 | -422.129234 |
|
| 14 | -400.143554 |
|
| 15 | -280.733826 |
|
| 16 | -253.837302 |
|
| 17 | -171.975747 |
|
| 18 | -9.092067 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -40355.1583 |
|
-50941.97665 |
|
| 2 | -3946.03884 |
|
-3938.52959 |
|
| 3 | -646.566375 |
|
-743.14917 |
|
| 4 | -520.11778 |
|
-517.183273 |
|
| 5 | -330.34635 |
|
-222.456375 |
|
| 6 | -296.984604 |
|
-140.505818 |
|
| 7 | -161.169448 |
|
-112.021112 |
|
| 8 | -147.309967 |
|
-91.507513 |
|
| 9 | -139.255035 |
|
-68.994408 |
|
| 10 | -133.881758 |
|
-67.328461 |
|
| 11 | -117.553169 |
|
-53.4713 |
|
| 12 | -108.187739 |
|
-33.617835 |
|
| 13 | -98.755098 |
|
||
| 14 | -97.892443 |
|
||
| 15 | -80.441717 |
|
||
| 16 | -76.647145 |
|
||
| 17 | -59.880385 |
|
||
| 18 | -57.904028 |
|
||
| 19 | -52.380557 |
|
||
| 20 | -24.427889 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -36491.908226 |
|
-40825.336818 |
|
| 2 | -2703.631521 |
|
-2986.647634 |
|
| 3 | -815.569845 |
|
-992.500411 |
|
| 4 | -667.452528 |
|
-490.701882 |
|
| 5 | -387.221895 |
|
-466.873446 |
|
| 6 | -294.515784 |
|
-364.524818 |
|
| 7 | -281.519289 |
|
-151.774878 |
|
| 8 | -265.31275 |
|
-147.715986 |
|
| 9 | -181.606869 |
|
-117.735641 |
|
| 10 | -127.329059 |
|
-99.175598 |
|
| 11 | -113.111355 |
|
-95.302644 |
|
| 12 | -96.602553 |
|
-81.132201 |
|
| 13 | -92.587646 |
|
-65.458048 |
|
| 14 | -76.867505 |
|
||
| 15 | -56.284617 |
|
||
| 16 | -55.062224 |
|
||
| 17 | -27.453276 |
|
||
| 18 | -14.451664 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 6.2e-52 |
|
| 3 | 3.8e-53 |
|
| 4 | 3.6e-35 |
|
| 5 | 1.4e-10 |
|
| 6 | 5.6e-10 |
|
| 7 | 1.8e-05 |
|
| 8 | 10.0 |
|
| 9 | 2500.0 |
|
| 10 | 4400.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 7.9e-84 |
|
1.8e-79 |
|
| 3 | 1.9e-28 |
|
500000.0 |
|
| 4 | 0.28 |
|
820000.0 |
|
| 5 | 290.0 |
|
1000000.0 |
|
| 6 | 46000.0 |
|
1900000.0 |
|
| 7 | 100000.0 |
|
3100000.0 |
|
| 8 | 630000.0 |
|
3400000.0 |
|
| 9 | 980000.0 |
|
4500000.0 |
|
| 10 | 980000.0 |
|
5600000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2.3e-66 |
|
4.1e-88 |
|
| 3 | 1.6e-36 |
|
2.1e-07 |
|
| 4 | 1.9e-07 |
|
2.2 |
|
| 5 | 0.11 |
|
130.0 |
|
| 6 | 19.0 |
|
68000.0 |
|
| 7 | 3600.0 |
|
480000.0 |
|
| 8 | 5100.0 |
|
900000.0 |
|
| 9 | 100000.0 |
|
2100000.0 |
|
| 10 | 130000.0 |
|
2200000.0 |
|