DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1572 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1993 |
|
| 5 | 1538 |
|
| 6 | 801 |
|
| 7 | 426 |
|
| 8 | 248 |
|
| 9 | 145 |
|
| 10 | 108 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 10524 |
|
12256 |
|
| 2 | 2885 |
|
3781 |
|
| 3 | 2169 |
|
675 |
|
| 4 | 247 |
|
801 |
|
| 5 | 281 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 9230 |
|
8768 |
|
| 2 | 4645 |
|
2568 |
|
| 3 | 1572 |
|
1588 |
|
| 4 | 118 |
|
785 |
|
| 5 | 172 |
|
||
| 6 | 7 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -33431.862277 |
|
| 2 | -7748.855121 |
|
| 3 | -6911.534137 |
|
| 4 | -6759.316903 |
|
| 5 | -5464.633324 |
|
| 6 | -5133.331434 |
|
| 7 | -4663.247782 |
|
| 8 | -4075.377896 |
|
| 9 | -4007.010862 |
|
| 10 | -3759.692744 |
|
| 11 | -3182.729898 |
|
| 12 | -1975.783862 |
|
| 13 | -1855.272085 |
|
| 14 | -1480.221571 |
|
| 15 | -1103.739211 |
|
| 16 | -1053.620198 |
|
| 17 | -1036.873272 |
|
| 18 | -955.406692 |
|
| 19 | -662.317328 |
|
| 20 | -622.34558 |
|
| 21 | -449.078735 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -22448.844485 |
|
-45271.425767 |
|
| 2 | -4244.889183 |
|
-8033.96078 |
|
| 3 | -2013.429126 |
|
-2754.109725 |
|
| 4 | -1773.289566 |
|
-932.024704 |
|
| 5 | -1106.154325 |
|
-636.489599 |
|
| 6 | -1065.805418 |
|
-499.140517 |
|
| 7 | -676.227752 |
|
-400.91218 |
|
| 8 | -657.719715 |
|
-215.56665 |
|
| 9 | -651.566075 |
|
-200.128746 |
|
| 10 | -560.253323 |
|
-132.066791 |
|
| 11 | -500.491219 |
|
-102.672688 |
|
| 12 | -460.279873 |
|
-98.10726 |
|
| 13 | -440.829849 |
|
-55.513807 |
|
| 14 | -361.319607 |
|
-34.720473 |
|
| 15 | -333.1987 |
|
||
| 16 | -313.185037 |
|
||
| 17 | -269.429523 |
|
||
| 18 | -99.429484 |
|
||
| 19 | -81.851326 |
|
||
| 20 | -35.87852 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -16487.155929 |
|
-21072.43457 |
|
| 2 | -3347.705304 |
|
-5157.940464 |
|
| 3 | -2732.820504 |
|
-4864.95966 |
|
| 4 | -2535.829202 |
|
-3755.813728 |
|
| 5 | -2087.131005 |
|
-1039.180116 |
|
| 6 | -1064.017553 |
|
-551.320927 |
|
| 7 | -933.36679 |
|
-411.485525 |
|
| 8 | -798.759436 |
|
-299.90311 |
|
| 9 | -795.105694 |
|
-138.033952 |
|
| 10 | -426.810689 |
|
-126.705459 |
|
| 11 | -368.94054 |
|
-118.232926 |
|
| 12 | -368.94054 |
|
||
| 13 | -257.840537 |
|
||
| 14 | -247.074638 |
|
||
| 15 | -226.247217 |
|
||
| 16 | -220.476244 |
|
||
| 17 | -162.103461 |
|
||
| 18 | -156.50986 |
|
||
| 19 | -28.630218 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 1.1e-169 |
|
| 3 | 4.4e-64 |
|
| 4 | 2.3e-45 |
|
| 5 | 5e-45 |
|
| 6 | 1.8e-40 |
|
| 7 | 6.6e-21 |
|
| 8 | 2.5e-14 |
|
| 9 | 1.6e-05 |
|
| 10 | 0.0091 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 3.3e-116 |
|
3.7e-205 |
|
| 3 | 6e-83 |
|
0.00036 |
|
| 4 | 2.5e-34 |
|
15000.0 |
|
| 5 | 5.4e-20 |
|
150000.0 |
|
| 6 | 2.6e-17 |
|
2100000.0 |
|
| 7 | 0.0001 |
|
2100000.0 |
|
| 8 | 10.0 |
|
2700000.0 |
|
| 9 | 26.0 |
|
4100000.0 |
|
| 10 | 170.0 |
|
4600000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1e-118 |
|
4.2e-164 |
|
| 3 | 5.8e-78 |
|
7.2e-152 |
|
| 4 | 9.2e-78 |
|
1.3e-138 |
|
| 5 | 5e-37 |
|
2.1e-13 |
|
| 6 | 8.9e-32 |
|
0.17 |
|
| 7 | 4.9e-09 |
|
2.5 |
|
| 8 | 0.48 |
|
2200.0 |
|
| 9 | 44.0 |
|
30000.0 |
|
| 10 | 60.0 |
|
160000.0 |
|