DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1975 |
|
| 5 | 1237 |
|
| 6 | 684 |
|
| 7 | 400 |
|
| 8 | 255 |
|
| 9 | 115 |
|
| 10 | 111 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 10171 |
|
9204 |
|
| 2 | 3541 |
|
2244 |
|
| 3 | 1528 |
|
397 |
|
| 4 | 624 |
|
353 |
|
| 5 | 146 |
|
||
| 6 | 6 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 8521 |
|
10490 |
|
| 2 | 4126 |
|
4534 |
|
| 3 | 856 |
|
566 |
|
| 4 | 440 |
|
136 |
|
| 5 | 7 |
|
141 |
|
| 6 | 57 |
|
||
| 7 | 31 |
|
||
| 8 | 1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -16753.851436 |
|
| 2 | -4073.382566 |
|
| 3 | -4010.093235 |
|
| 4 | -3679.353153 |
|
| 5 | -3629.883251 |
|
| 6 | -3019.06886 |
|
| 7 | -2383.103977 |
|
| 8 | -2062.329642 |
|
| 9 | -1883.377548 |
|
| 10 | -1207.809743 |
|
| 11 | -1075.856862 |
|
| 12 | -1017.902963 |
|
| 13 | -985.699754 |
|
| 14 | -907.58392 |
|
| 15 | -710.688609 |
|
| 16 | -626.610637 |
|
| 17 | -602.7199 |
|
| 18 | -513.152551 |
|
| 19 | -493.260766 |
|
| 20 | -178.322196 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -23919.701228 |
|
-38063.422152 |
|
| 2 | -2504.832579 |
|
-3176.305662 |
|
| 3 | -806.397651 |
|
-412.290496 |
|
| 4 | -609.158043 |
|
-289.756436 |
|
| 5 | -447.891197 |
|
-262.867292 |
|
| 6 | -389.221737 |
|
-252.226006 |
|
| 7 | -387.048369 |
|
-189.911639 |
|
| 8 | -350.308822 |
|
-140.968486 |
|
| 9 | -316.867704 |
|
-111.550292 |
|
| 10 | -311.201783 |
|
-107.250385 |
|
| 11 | -296.571217 |
|
-106.181037 |
|
| 12 | -224.648009 |
|
-91.371992 |
|
| 13 | -214.146019 |
|
-84.61473 |
|
| 14 | -133.304097 |
|
-80.204124 |
|
| 15 | -119.479438 |
|
-53.650211 |
|
| 16 | -118.889463 |
|
-33.263825 |
|
| 17 | -81.666082 |
|
-26.977346 |
|
| 18 | -25.81566 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -15690.096072 |
|
-27388.952787 |
|
| 2 | -4417.203786 |
|
-5778.26107 |
|
| 3 | -2852.863338 |
|
-4221.676602 |
|
| 4 | -1471.745233 |
|
-1660.357363 |
|
| 5 | -1244.508496 |
|
-602.387024 |
|
| 6 | -887.123245 |
|
-599.550135 |
|
| 7 | -802.587454 |
|
-524.067346 |
|
| 8 | -768.010763 |
|
-491.698005 |
|
| 9 | -618.577642 |
|
-470.779283 |
|
| 10 | -364.370175 |
|
-407.775526 |
|
| 11 | -323.987148 |
|
-349.877731 |
|
| 12 | -309.247978 |
|
-175.355576 |
|
| 13 | -215.524859 |
|
-64.072057 |
|
| 14 | -189.48593 |
|
||
| 15 | -179.047449 |
|
||
| 16 | -176.568854 |
|
||
| 17 | -153.972922 |
|
||
| 18 | -115.126555 |
|
||
| 19 | -40.149588 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 1.1e-82 |
|
| 3 | 1.1e-35 |
|
| 4 | 2.7e-21 |
|
| 5 | 3.3e-21 |
|
| 6 | 5.3e-21 |
|
| 7 | 6.5e-17 |
|
| 8 | 5.2e-12 |
|
| 9 | 4.4e-10 |
|
| 10 | 2.5e-07 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.2e-93 |
|
5.2e-144 |
|
| 3 | 1.8e-38 |
|
3.6e-05 |
|
| 4 | 0.00035 |
|
0.21 |
|
| 5 | 0.0014 |
|
1000.0 |
|
| 6 | 12000.0 |
|
8400000.0 |
|
| 7 | 7600.0 |
|
5800000.0 |
|
| 8 | 17000.0 |
|
12000000.0 |
|
| 9 | 38000.0 |
|
14000000.0 |
|
| 10 | 5500000.0 |
|
14000000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 4.1e-81 |
|
3.6e-199 |
|
| 3 | 5.5e-39 |
|
1.7e-95 |
|
| 4 | 3e-27 |
|
4e-22 |
|
| 5 | 1.2e-25 |
|
0.037 |
|
| 6 | 1.1e-16 |
|
0.24 |
|
| 7 | 0.00085 |
|
570.0 |
|
| 8 | 0.023 |
|
780.0 |
|
| 9 | 5500.0 |
|
1100.0 |
|
| 10 | 7600.0 |
|
10000.0 |
|